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All Journal Indonesian Journal of Chemistry
Puttinan Meepowpan
Department of Chemistry, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Graduate School, Chiang Mai University, 239 Huay Kaew Road, Chiang Mai 50200, Thailand
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Anticancer Activities of Chemical Constituents from Leaves and Twigs of Mitrephora winitii Sukee Sukdee; Puttinan Meepowpan; Narong Nantasaen; Siriporn Jungsuttiwong; Sarinya Hadsadee; Wilart Pompimon
Indonesian Journal of Chemistry Vol 21, No 3 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.61085

Abstract

The genus Mitrephora has been investigated and its anti-inflammatory, anti-bacterial and anti-parasitical activities were examined along with its potential as an anti-cancer cell line and inhibitor for platelet aggregation. In this work, air-dried leaves and twigs of M. winitii were grounded and extracted with n-hexane, ethyl acetate and methanol, respectively. Chromatographic separations of these extracts led to the isolation of three known compounds and one new compound (compound 2). The chemical structures of these were identified using spectroscopic investigation of 1D- and 2D-NMR and the resulting data confirmed these as stigmasterol (1), (3,4-dimethoxyphenyl)(5-(3,4-dimethoxyphenyl)-4-(hydroxymethyl)tetrahydrofuran-3-yl)methanol (2), diayangambin (3), and methyl-L-inositol (4). The chemical constituents were reported the first time in M. winitii. Compound 2 showed anti-cancer cell lines with ED50 13.07 µg/mL against KB cells and then was tested for cytotoxicity against MCF-7 cells with ED50 11.77 µg/mL.
Co-Authors Narong Nantasaen Sarinya Hadsadee Siriporn Jungsuttiwong Sukee Sukdee Wilart Pompimon