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All Journal Journal of Mathematical and Fundamental Sciences Indonesian Journal of Chemistry
Yoshihito Shiono
Department of Bioresources Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka-shi, Yamagata 997-8555, Japan
Astronomy Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Mathematics Physics

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Sesquiterpenoids from the Stem Bark of Aglaia simplicifolia and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell Ghina Izdihar; Al Arofatus Naini; Desi Harneti; Rani Maharani; Nurlelasari Nurlelasari; Tri Mayanti; Agus Safari; Kindi Farabi; Unang Supratman; Mohamad Nurul Azmi; Yoshihito Shiono
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.68383

Abstract

Four sesquiterpenoid derivatives, i.e., 4β,10α-dihydroxyaromadendrane (1), caryophyllenol-II (2), senecrassidiol (3), and clovane-2β,9α-diol (4) have been isolated from the stem bark of Aglaia simplicifolia. The chemical structures of compounds 1-4 were determined based on spectroscopic data, including one and two-dimensional NMR and mass spectroscopy. In addition, these sesquiterpenoids 1-4, were also tested for their cytotoxic activity against B16-F10 melanoma skin cancer cell lines through in vitro assay. Among the isolated compounds 1-4, compound 1 showed the highest activity with an IC50 value of 44.8 μg/mL, suggesting the presence of a cyclopropane ring that plays an essential role in cytotoxic activity against B16-F10 melanoma skin cancer cell lines.
Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae) Dudi Runadi; Purnama Purnama; Supriatno Salam; Nulelasari Nurlelasari; Desi Harneti; Tri Mayanti; Rani Maharani; Unang Supratman; Yoshihito Shiono
Journal of Mathematical and Fundamental Sciences Vol. 54 No. 3 (2023)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2023.54.3.2

Abstract

A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 ± 0.21 mM.
Co-Authors Agus Safari Al Arofatus Naini Desi Harneti Putri Huspa Dudi Runadi Ghina Izdihar Kindi Farabi Mohamad Nurul Azmi Nulelasari Nurlelasari Nurlelasari Nurlelasari Purnama Purnama Rani Maharani Rani Maharani Supriatno Salam Tri Mayanti Tri Mayanti Unang Supratman