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All Journal Jurnal Kesehatan Andalas ANNALES BOGORIENSES Cermin Dunia Kedokteran Cermin Dunia Kedokteran
Azamris Azamris
Departemen Bedah, Fakultas Kedokteran Universitas Andalas, RS M. Djamil, Padang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hubungan Interval Waktu Antara Usia Menarche Dan Usia Saat Melahirkan Anak Pertama Cukup Bulan Dengan Kejadian Kanker Payudara Di Rsup Dr.M.Djamil Padang Pada Tahun 2014-2017 Rusydah Syarlina; Azamris Azamris; Avit Suchitra; Wirsma Arif Harahap
Jurnal Kesehatan Andalas Vol 8, No 1 (2019): Online Maret 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i1.965

Abstract

Interval usia saat menarche dan usia saat melahirkan anak pertama cukup bulan merupakan panjang waktu antara usia saat haid pertama kali dan usia saat melahirkan bayi cukup bulan pertama kali. Interval ini diduga merupakan salah satu faktor risiko terhadap KPD. Tujuan penelitian ini adalah menentukan hubungan antara interval usia saat menarche dan usia saat melahirkan anak pertama cukup bulan terhadap kejadian kanker payudara di RSUP Dr.M.Djamil Padang pada tahun 2014-2017. Penelitian ini merupakan studi case control terhadap 102 orang yang terbagi menjadi 2 kelompok, yaitu kelompok kasus dan kelompok kontrol. Pengumpulan data dilakukan melalui wawancara menggunakan tabel faktor risiko kanker payudara yang merupakan modifikasi dari Breast Cancer Risk Assessment Tools–National Cancer Institute dan data pasien dari bagian Bedah RSUP Dr.M.Djamil Padang tahun 2014-2017. Hasil analisis statistik menunjukkan usia menarche tertinggi pada kasus adalah 12 dan 13 tahun dan pada kontrol 13 tahun. Usia saat melahirkan anak pertama cukup bulan tertinggi pada kasus dan kontrol adalah 23 tahun. Frekuensi berdasarkan interval waktu usia menarche dan usia saat melahirkan anak pertama cukup bulan ≥ 10 tahun pada kasus dan kontrol secara berurutan adalah 58,8% dan 66,7%. Simpulan studi ini ialah tidak terdapat hubungan bermakna secara statistik antara interval waktu usia menarche dan usia saat melahirkan anak pertama cukup bulan ≥ 10 tahun dengan kejadian kanker payudara (p > 0,05).
Improvement of HER2I655V TARMS-PCR Performance by DNA Quality Analysis Bugi Ratno Budiarto; Azamris Azamris; Desriani Desriani
ANNALES BOGORIENSES Vol 21, No 2 (2017): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (822.051 KB) | DOI: 10.14203/ann.bogor.2017.v21.n2.52-62

Abstract

Reliable TARMS-PCR is a prerequisite in constructing a solid conclusion in genetic diagnostics. The validity of data generated by this molecular technique is hampered by a false positive result. In attempt to develop a  TARMS-PCR for HER2I655V genotyping with no interfering of bias we used DNase I to eliminate DNA contaminant resided in PCR reagent. TARMS-PCR without enzyme treatment using recombinant plasmids that contained HER2I655V gene with represented its alleles was used to evaluate the presence of false positive  result while DNase I treated-PCR reagent was used in TARMS-PCR to evaluate the effective dose of the enzyme and further to adjust the TARMS-PCR conditions.  PCR master mix kit used in this study produced a false positive result on HER2I655V TARMS-PCR as proven by the presence of multiple PCR products in Non-Template Control (NTC) and 0.1 U of the enzyme could eliminate this DNA contaminant effectively, although this pretreatment altered the specificity of HER2I655V TARMS-PCR genotyping on certain genotype. Combination of touchdown TARMS-PCR with another allele-specific primer recovered specificity of detection on this model system. Interestingly, this optimized HER2I655V TARMS-PCR can only be used for genotyping the clinical samples if only further optimization was done using genomic DNA as template
ILE655VAL Genotyping Study of HER2 - Positive Breast Cancer of Patients from Padang - Indonesia With High Resolution Melting Technique Dwi Wulandari; Azamris Azamris; Isna Nurhayati; M Ali Warisman; Bugi Ratno Budiarto; Desriani Desriani
ANNALES BOGORIENSES Vol 21, No 2 (2017): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (282.104 KB) | DOI: 10.14203/ann.bogor.2017.v21.n2.69-75

Abstract

Transtuzumab has proven to be a great improvement in the treatment of HER2 + of breast cancer patients, but it is associated with relevant adverse cardiac events and with significantly elevated cost of treatment.  One of the risk factors for cardiotoxicity due to transtuzumab is the I655V HER2 polymorphism (GTC> ATC mutation) in which the allele mutant (Ile val or val / val) has a higher risk than the wild type (Ile/Ile). The detection of specific alleles is very important for therapeutic decision-making. In this study, our group have developed a HRM with EvaGreen dye method to discriminate specific allele of I655V HER2 (wild type, heterozygote mutant or homozygote mutant) in 66 frozen section samples of HER2+ of breast cancer patients. Our group reported the wild type is the most prevalent allele (77,27%), whereas heterozygous mutation is significantly present in this research (21,21%) and only 1,52% of sample detected as minor allele.  It showed that only one sample detected as a minor allele (val/val) and may have relatively low abundance in the population. This method has been compared with sanger sequencing and giving 100% of validity.
Tumor Phyllodes Azamris -
Cermin Dunia Kedokteran Vol 41, No 1 (2014): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v41i1.1173

Abstract

Tumor phyllodes merupakan keganasan payudara yang jarang ditemukan. Insidensnya hanya sekitar 0,3-0,9% dari seluruh tumor payudara. Manifestasi klinis tumor phyllodes umumnya berupa benjolan unilateral yang dapat diraba, tunggal, tidak nyeri. Terapi utama adalah pembedahan komplit. Peran radioterapi dan kemoterapi adjuvan masih kontroversial. Dilaporkan 8 kasus tumor phyllodes di rumah sakit Dr.M.Djamil Padang selama 2011-2012. Enam kasus (75%) varian jinak dan dua kasus (25%) varian borderline. Telah dilakukan terapi definitif pada tujuh pasien, satu pasien meninggal sebelum mendapat terapi definitif.Phyllodes tumor is a rare breast malignancy. The incidence is only about 0.3-0.9% of all breast tumors. Clinical manifestations consist of unilateral single palpable lump not accompanied by pain. Surgery is the main therapeutic modality. The role of radiotherapy and adjuvant chemotherapy are still controversial. Eight cases of phyllodes tumors was reported at Dr.M.Djamil Padang Hospital in 2011-2012. Six cases were benign variants and two cases were borderline variants. Definitive therapy has been performed in seven patients, one patient died before it was performed. 
Perbandingan Efektivitas Lama Pemakaian Drain Pasif untuk Mencegah Seroma Pasca-Modified Radical Mastectomy Azamris -
Cermin Dunia Kedokteran Vol 42, No 2 (2015): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i2.1036

Abstract

Pembedahan merupakan tindakan utama pada penderita karsinoma payudara, dengan pilihan utama modified radical mastectomy. Seroma merupakan masalah yang paling sering terjadi setelah tindakan mastektomi, dan paling sulit dicegah dibandingkan komplikasi lain. Penumpukan cairan ini akan memperlama masa rawat dan menambah biaya rawat. Untuk mengurangi terbentuknya seroma, dapat dipasang drain. Drainase dapat berupa suction drain atau drain pasif. Dilakukan penelitian prospektif terhadap 32 orang penderita karsinoma payudara yang menjalani modified radical mastectomy dari bulan Februari sampai Juli 2010. Penderita dibagi 2 kelompok, satu kelompok 16 penderita dengan drainase yang dilepas sesudah 4 hari, dan kelompok kedua drainase dilepas sesudah 8 hari. Jumlah seroma terakhir saat drainase dibuka rata-rata 15 mL pada yang dilepas cepat dan 4,06 mL pada yang dilepas lambat (t= 4,973; p=0,000). Semua seroma pasca-pelepasan drainase rata-rata kurang dari 50 mL. Disimpulkan bahwa efektifitas drainase pasif yang dilepas cepat dibandingkan dengan yang dilepas lambat tidak berbeda bermakna, sehingga lama rawat pasien dapat berkurang jika drainase dilepas cepat.Modified Radical Mastectomy is the treatment of choice for operable breast cancer. Seroma is the most frequent problem after mastectomy and difficult to prevent. This accumulation of liquid will prolong hospitalization and need extra cost. This problem is usually solved by drainage, either with suction drain or passive drain. A prospective trial has been conducted on 32 breast carcinoma patients who underwent a modified radical mastectomy from February until July 2010. The patients are divided into two groups, the first group consists of 16 patients whose drain was extracted after 4 days, the second group had their drains extracted after 8 days. Mean total seroma collected in the first group was 15 mL, and in the second group was 4,06 mL. (t= 4,973; p= 0,000). Seroma after drain extraction were less than 50 mL. No significant difference on the effectivity of extraction of drain after 4 days or after 8 days, and the length of stay could be shortened.
Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid Oktahermoniza .; Heldrian Dwinanda Suyuthie; Ari Oktavenra; Sondang Nora; Daan Khambri; Wirsma Arif Harahap; Rony Rustam; Azamris .
Cermin Dunia Kedokteran Vol 49, No 1 (2022): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.1645

Abstract

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan. Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery. 
Hubungan Jenis Operasi dengan Angka Ketahanan Hidup Sepuluh-tahun Penderita Kanker Tiroid Diferensiasi Baik di RSUP Dr. M. Djamil, Padang Azamris -
Cermin Dunia Kedokteran Vol 44, No 5 (2017): Gastrointestinal
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i5.792

Abstract

Latar Belakang : Kanker tiroid merupakan keganasan endokrin tersering dan diperkirakan 1,1 % dari seluruh keganasan manusia, pertumbuhan dan perjalanan penyakitnys umumnya lambat, morbiditas dan mortalitas rendah, terutama pada kanker berdiferensiasi baik. Jenis tindakan bedah untuk kanker tiroid berdiferensiasi baik (KTD) masih kontroversial. Penelitian ini mencari hubungan jenis operasi dengan angka ketahanan hidup 10 tahun penderita kanker tiroid berdiferensiasi baik di RSUP Dr.M.Djamil Padang. Metode : Penelitian retrospektif pada penderita kanker tiroid di RSUP Dr.M.Djamil Padang dari tanggal 1 Januari 2004 sampaidengan 31 Desember 2013. Pengambilan data di bagian rekam medik, langsung pada pasien poliklinik bedah, melalui kunjungan rumah ataupun via telepon. Analisis data secara analitik komparatif, untuk mencari hubungan 2 variabel digunakan uji chi square dengan derajat kepercayaan 95%. Hasil : Dari 62 sampel penelitian, 27 penderita termasuk kelompok risiko rendah. Masih terdapat perbedaan jenis operasi KTD kelompok risiko rendah. Pada jenis operasi yang lebih konservatif tidak ditemukan komplikasi operasi dengan perbedaan angka ketahanan hidup 10 tahun tidak bermakna dibandingkan tiroidektomi total. Background: Thyroid cancer is the most frequent endocrine malignancy, approximately 1,1% among all malignancies in human. Most thyroid cancers are slowly developing and progressing with low morbidity and mortality, mainly in well-differentiated cancer. Surgical treatment choices for well-differentiated thyroid cancer are still controversial. This study tried to find out relationship between type of surgeries and 10-year survival in well differentiated cancer patients in RSUP. Dr. M. Djamil Padang. Method: This study is a retrospective study on data from thyroid cancer patients in RSUP Dr. M. Djamil Padang from January 1st 2004 until December 31st 2013. Data was collected from medical record, directly from patients in the clinic, home visit and by phone call. Comparative analysis was used to find correlation between two variables, chi square test was used with 95% accuracy. Result: From 62 individuals, 27 patients had low risk well-differentiated thyroid cancer. There are still some variations of surgery methods in low-risk well-differentiated thyroid cancer patients, No postsurgery complication in more conservative surgery; the 10-year survival rate isn't statistically different compared to total thyroidectomy.
Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid Oktahermoniza; Heldrian Dwinanda Suyuthie; Ari Oktavenra; Sondang Nora; Daan Khambri; Wirsma Arif Harahap; Rony Rustam; Azamris
Cermin Dunia Kedokteran Vol 49 No 1 (2022): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.189

Abstract

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan. Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery.
Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid Oktahermoniza; Heldrian Dwinanda Suyuthie; Ari Oktavenra; Sondang Nora; Daan Khambri; Wirsma Arif Harahap; Rony Rustam; Azamris
Cermin Dunia Kedokteran Vol 49 No 1 (2022): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.189

Abstract

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan. Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery.
Co-Authors Ari Oktavenra Avit Suchitra Bugi Ratno Budiarto Bugi Ratno Budiarto Daan Khambri Desriani Desriani Desriani Desriani Dwi Wulandari Isna Nurhayati M Ali Warisman Oktahermoniza Oktahermoniza . Rony Rustam Rusydah Syarlina Sondang Nora Sondang Nora Suyuthie, Heldrian Dwinanda Wirsma Arif Harahap