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Ida Bagus Sutha
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Medicine & Pharmacology

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ASPEK PULMONOLOGIS INFEKSI OPORTUNISTIK PADA INFEKSI HIV/AIDS Agustriadi, Ommy; Sutha, Ida Bagus
journal of internal medicine Vol. 9, No. 3 September 2008
Publisher : journal of internal medicine

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Abstract

Human Immunodeficiency Virus (HIV) known as etiologic agent for AIDS (Acquired Immunodeficiency Syndrome), inwhich followed or accompanied by certain opportunistic infections and malignancies. Perhaps the most important reason for thefrequent development of diverse pulmonary complications in HIV/AIDS relates to the fact that the lung is chronically exposed toboth infectious or non-infectious airborne agents (exogenously) and hematogenously spread agents (endogenously) through anexpansive surface area consisting of millions of units called alveoli, that infected alveolar macrophages and lymphocytes.The mechanisms that may play role of defected lung defend mechanisms were direct effect of HIV that infected and killcells cause damaged to the effector cells and shifted cells function from immunostimulative to immunosupressive, then impairedmigration capacity of lymphocytes, monocytes or netrophils to lung. In turn, the opportunistic infections easily developed.In almost 65% AIDS patients also accompanied with oppportunistic infections in the lung. Pneumocystis cariniipneumoniae was the most often, followed by M. tuberculosis infection, bacterial and fungal pneumoniae respectively. Whereas,viral pneumoniae was rare
Co-Authors Ommy Agustriadi