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All Journal Jurnal Penelitian Farmasi Indonesia
Widya Rahmah
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Medicine & Pharmacology

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KARAKTERISASI BAKTERI ASAM LAKTAT (BAL) DARI FERMENTASI TAPE SINGKONG: CHARACTERIZATION OF LACTIC ACID BACTERIA (LAB) FROM FERMENTATION OF CASSAVA TAPE Widya Rahmah; Erika Nandini; Sylvan Septian Ressandy; Hasyrul Hamzah
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 1 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i1.1166

Abstract

Indonesia is famous for its wide variety of fermented traditional foods. The type of traditional fermented food that is often found is cassava tape which is made from carbohydrate food using yeast which belongs to the lactic acid bacteria (LAB) group. This study aims to isolate and characterize LAB as probiotics from fermented cassava tape food. The research methods used were the manufacture of sample suspensions, isolation, and purification of microbes, observation of the morphology of the colonies, gram staining of bacterial isolates, acid resistance test, and bile salt resistance test. Based on the results of research from 4 types of samples with different dilutions, macroscopic tests on all samples had irregular colony edge shapes with 3 types of samples of umbonate colony elevation and 1 spreading sample, as well as 2 samples of umbonate colony shape and 2 others spreading. In the microscopic test, all samples belonged to the Gram-positive bacteria group and were rod-shaped. Meanwhile, in the characteristic test of probiotic isolates against pH and bile salts using MRSB medium with two different pH variations, namely pH 2.5 and pH 3, the results showed that there were deposits on the growth of the isolates where the acidity test stated that LAB had met all the test requirements. probiotics. However, in the bile salt resistance test, all isolates grew more optimally on a medium containing 1% ox bile compared to 5% concentration. Therefore, cassava tape can be used as a source of lactic acid bacteria as probiotics.
POTENSI TANAMAN MANGROVE SEBAGAI AGEN ANTIKANKER: LITERATURE REVIEW Widya Rahmah
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 1 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i1.1168

Abstract

Cancer is a disease caused by the abnormal growth of body tissue cells that will become cancer cells. Cancer is still one of the world's biggest problems. Cancer causes quite a large number of deaths, in 2018 there were 17 million cases of cancer which caused 9.5 million deaths of the world's population due to cancer. Indonesia is listed as a country that has the richest mangrove species in the world. Mangrove plants have many benefits for health, one of which is as an anticancer. The purpose of writing this literature review is to provide information and an overview of the content of secondary metabolites and bioactive compounds contained in mangrove plants, as well as to determine the potential of mangrove plants as anticancer agents. In the preparation of this literature review, a secondary research method without specific guidelines in writing (non-systematic review) was used, namely the narrative review approach method. This is done by collecting data related to research topics from various electronic and non-electronic libraries. Based on several research results, it is known that mangrove plant extracts have cytotoxic activity against myeloma cancer cells with an IC50 of 508.19 g/mL. The results of the isolation of squalene compounds have an effect as an anticancer in the stomach with potential cytotoxic activity against MCF-7 cancer cells with IC50 values ​​of 644.008 and 595.164μg/mL, respectively. So it's a shame if we don't explore this potential and use it to the fullest for the common good. Many universities and research institutes have explored various plants as sources of medicine but have not looked at the benefits of mangroves.
Co-Authors Erika Nandini Hamzah, Hasyrul Sylvan Septian Ressandy