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All Journal Bioeksperimen: Jurnal Penelitian Biologi Walisongo Journal of Chemistry JPP Jurnal Kesehatan Poltekkes Palembang Jurnal Medikes (Media Informasi Kesehatan) Bantenese Jurnal Pengabdian Masyarakat KAIBON ABHINAYA : JURNAL PENGABDIAN MASYARAKAT Journal of Noncommunicable Diseases Prevention and Control
Nurmeily Rachmawati
Poltekkes Kemenkes Banten
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Walisongo Journal of Chemistry

 1 
Cytotoxic Activity of Ethanol Extract in Namnam Leaves (cynometra cauliflora l.) to Hela Cell Syarah Anliza; Nurmeily Rachmawati
Walisongo Journal of Chemistry Vol 4, No 2 (2021): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v4i2.7999

Abstract

Cervical cancer is one of the most prominent death cases after breast cancer for a woman in Indonesia. Several treatments can be conducted to cure cancer such as chemotherapy, radiotherapy, tumor surgery, and others. In addition, people can consume some medicines or natural substances that can suppress cancer growth. The natural substances contain active compounds that have the potential as anticancer. One of the natural substances used in this research is the Namnam leaves which grow in Southeast Asia.  The purpose of this research was to determine the potential compounds in Namnam leaves extract by cytotoxic activity testing by using HeLa cells. The active compound in the Namnam leaves extract was obtained by using the maceration method with ethanol for 3x24 hours. The extract was then tested by BSLT method and proliferation by using HeLa cancer cells (ATCC CCL-2). The toxicity results showed that LC50 value was 125,89 μg/mL. This result indicated that the extract belongs to the moderate toxic category and has potential as an anticancer agent. Proliferation test in inhibiting of HeLa cancer cells used Microculture Tetrazolium Technique (MTT) method. The result showed that the extract with a concentration of 25 μg/mL could inhibit the proliferation of HeLa cancer cells by 57,51%.
Pengaruh Adsorben Sebagai Media Filter dalam Menurunkan Kadar Timbal dalam Matrik Air Sungai Nurmeily Rachmawati
Walisongo Journal of Chemistry Vol 3, No 2 (2020): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v3i2.6448

Abstract

Usaha untuk mendapatkan air bersih dapat dilakukan dengan melakukan proses filterisasi. Salah satu sumber air yang dimanfaatkan untuk mendapatkan air bersih adalah air sungai. Sungai Cisadane yang terletak di Kota Tangerang ditemukan kadar logam timbal dengan kadar yang melebihi ambang batas baku mutu. Oleh sebab itu diperlukan suatu usaha untuk menurunkan kontaminan logam timbal dalam air sungai tersebut. Tujuan penelitian ini yaitu mendapatkan informasi bagaimana adsorben alami dapat dimanfaatkan sebagai media filter dalam menurunkan kontaminan logam timbal tersebut. Metode penelitian ini merupakan ekperimental laboratorium dengan merancang media filter yang berisikan adsorben alami. Jumlah adsorben yang digunakan berjumlah 8 yaitu arang aktif (AA), zeolite (Z), sekam padi bakar (SPB), pasir silica (PS), jerami padi (JP), serbuk kayu (SK), sekam padi (SP), dan serabut kelapa (CH). Hasil yang diperoleh terjadi penurunan kontaminan logam berat dikedelapan adsorben yang digunakan. Adsorben zeolite, serbuk kayu, dan serabut kelapa mampu menurunkan kontaminan logam berat sebesar 90% dari konsentrasi awal logam timbal yang ditambahkan kedalam matrik air sungai tersebut. Berdasarkan uji statistic paired t-test juga ditemukan perbedaan yang nyata antara sebelum dan sesudah filterisasi di kedelapan adsorben tersebut yang ditunjukkan dengan nilai Sig (2-tailed) α = 0,025.
Co-Authors Ahmad Yani Diana Rinawati Muhamad Abdul Rifai Patricia, Venny Srimaya Winahyu Syarah Anliza