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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Berkala Ilmiah Kimia Farmasi
Muh. Agus Syamsur Rijal
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Medicine & Pharmacology Other

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Potential of Collagen as an Active Ingredient in Cosmetics Denayu Pebrianti; Mikhael Ardi Kristiawan; Rima Hidayatul Qoiriyah; Siti Nur Kholisah; Aulia Hanin Fakhira; Laila Nur Azizah; Cindi Dia Rakhmawati; Muhammad Hilal Salim; Aviatus Solikhah; Rohana Ayu Pramesti; Rika Putri Septiawati; Melanny Ika Sulistyowati; Muh. Agus Syamsur Rijal
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i2.46518

Abstract

Skin was the part of the outer body that was most often exposed to external factors, especially ultraviolet radiation. The skin had an important role in supporting the appearance so that it could affect human social life. Skin aging was a process of decreasing the body's physiological functions that could not be avoided. The aging process of the skin could be caused by a decrease in collagen density and replacement of essential structural proteins so that the skin loses its integrity and elasticity. Collagen was the most abundant protein in humans which could be found in bones, muscles, skin and tendons. Several studies had shown that damaged collagen fibers could be replaced by new fibers when collagen production was stimulated, which was why many cosmetic industries were competing to develop the use of collagen. Collagen had shown potential as an antioxidant, skin moisturizer, and anti-aging. Therefore, this article examined the benefits of collagen, especially in the cosmetic field. This article also discussed the sources of collagen with the best properties as active ingredients for skin care products. Keywords:  Collagen, Cosmetics, Antioxidants, Moisturizers, Anti-Aging
Effect of CaCl2 Crosslinker Concentration On The Characteristics, Release and Stability of Ciprofloxacin HCl-Alginate-Carrageenan Microspheres Amiruddin; Muh. Agus Syamsur Rijal; Dewi Melani Hariyadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.312-323

Abstract

Background: Ciprofloxacin HCl is a broad-spectrum fluoroquinolone antibiotic that has the lowest MIC against Mycobacterium tuberculosis but has limitations in oral use, so inhalation microspheres are made. Objective: This study aimed to investigate the effect of CaCl2 crosslinker concentration on the characteristics, release and stability of ciprofloxacin-alginate-carrageenan microspheres. Methods: Microspheres were prepared by ionotropic gelation using aerosolization with calcium chloride 0.5M (F1), 1.0M (F2), 1.5M (F3), 2.0M (F4) as crosslinker and then dried using freeze dryer. Results: Ciprofloxacin-alginate-carrageenan microspheres formed of yellowish-white powder, smooth morphology and excellent flow properties with the particle size of less than 5µm, drug loading and entrapment efficiency were between    2.05% - 2.42% and 75.34% - 98.09%, yield was between 84.69% - 97.57%, moisture content of less than 10%. Ciprofloxacin-alginate-carrageenan microspheres with 1.5M crosslinker (F3) was the optimal formula. For 12 hours, ciprofloxacin released was 49.89% - 63.78% at pH 7.4, and the kinetics of drug release showed that of Korsmeyer-peppas with a mechanism based on fickian diffusion. The microspheres were discovered to be stable for up to 28 days of storage. Conclusion: The increased concentration of the CaCl2 crosslinker from 0.5M to 2.0M decreased the particle size and drug release but increased the yield, drug loading and entrapment efficiency.
Co-Authors Amiruddin Aulia Hanin Fakhira Aviatus Solikhah Cindi Dia Rakhmawati Denayu Pebrianti Dewi Melani Hariyadi Laila Nur Azizah Melanny Ika Sulistyowati Mikhael Ardi Kristiawan Muhammad Hilal Salim Rika Putri Septiawati Rima Hidayatul Qoiriyah Rohana Ayu Pramesti Siti Nur Kholisah