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All Journal Health and Medical Journal Jurnal manajemen informasi kesehatan
Pamudji Utomo
Universitas Sebelas Maret
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Functional Evaluation of Sciatic Nerve Anastomosis Wraped by Freeze Dried Human Amniotic Membrane in Sprague Dawley Rat Eko Perdana Putra; Pamudji Utomo; Mujaddid Idulhaq
Health and Medical Journal Vol 2, No 1 (2020): HEME January 2020
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (680.567 KB) | DOI: 10.33854/heme.v2i1.259

Abstract

Background. Peripheral nerve injury (PNI) is a common medical condition. The defected nerve, if not repaired as early as possible, can cause long-term denervation and neurotrophy failure for the target organ. This leads to a series of denervation manifestations, such as muscle atrophy, loss of sensory function, etc. and ultimately, these manifestations seriously affect the patient’s sensorimotor function.1,2  Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for sciatic nerve repair.Material and methods. A post test only control group design has been done  in 10 healthy Sprague Dawley rats. In all rats, a unilateral right side sciatic nerve transection was performed and reanastomosed by different methods: Group I (control group): included 5 rats, the anastomosis was done by epineural microsutures using 8/0 nylon. Group II: included 5 rats, the anastomosis was done by epineural microsutures using 8/0 nylon and  then wraped by freeze dried human amniotic membrane. Functional evaluation of nerve recovery was done over 3 weeks postoperatively using walking tract analysis and calculate using Sciatic Functional Index.Result. Functional results showed that there was no significant difference of the sciatic functional index (SFI) between group I and group II.Conclusion. We can conclude that during 3 weeks functional evaluation, there is no significant difference between control group and  experimental group that achieved freeze dried human amniotic membrane.Keywords: sciatic nerve injury, freeze dried human amniotic membrane, walking tract analysis, sciatic functional index.
Comparative Effects of Isometric and Isotonic Progressive Continuous Exercise on miRNA-155 Expression Following Sports-Related Muscle Injury Moh. Ali Imron; Suci Muqodimatul; I Made Jawi; I Putu Gede Adiatmika; Pamudji Utomo
Jurnal Manajemen Informasi Kesehatan (Health Information Management) Vol. 11 No. 1 (2026): Health Information and Management
Publisher : Sekolah Tinggi Ilmu Kesehatan Sapta Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51851/jmik.v11i1.1034

Abstract

Background: Background: Muscle injury often causes pain, inflammation, and reduced function. MicroRNA-155 (miRNA-155) is involved in inflammatory regulation and tissue regeneration after skeletal muscle injury. Exercise rehabilitation may influence these molecular responses, but evidence regarding different exercise modalities remains limited. Objective: To compare the effects of isometric progressive continuous exercise (MPCE) and isotonic progressive continuous exercise (NPCE) on miRNA-155 expression in athletes with grade 1–2 muscle injury. Method: A true experimental randomized pretest–posttest control group design was used. Twenty-one athletes with grade 1–2 muscle injury were randomly assigned to MPCE (n = 7), NPCE (n = 7), or control (CON; n = 7). Intervention groups performed progressive continuous exercise once daily for 7 consecutive days, while the control group received no exercise intervention. Venous blood samples were collected before and after intervention, and miRNA-155 expression was analyzed using real-time quantitative polymerase chain reaction (qPCR). Data were analyzed using within-group tests, Kruskal–Wallis, and post-hoc analysis.. Result: In the MPCE group, miRNA-155 increased from 0.583 ± 0.5 to 3.700 ± 3.6, but the change was not significant (p = 0.066). In the NPCE group, miRNA-155 significantly decreased from 14.273 ± 1.3 to 5.645 ± 3.6 (p = 0.001). The control group showed no significant change from 1.119 ± 1.6 to 1.598 ± 1.4 (p = 0.310). Between-group analysis showed significant differences in baseline values (H = 13.406, p = 0.001) and change scores (H = 12.276, p = 0.002). Post-hoc analysis revealed significant differences between both intervention groups and control, while no difference was found between MPCE and NPCE. Conclusion: Progressive continuous exercise significantly modulated miRNA-155 expression compared with the control group. However, no significant difference was found between MPCE and NPCE, and results should be interpreted with caution due to baseline imbalance. Further studies with larger samples and adjusted analyses are warranted.
Co-Authors Eko Perdana Putra I Made Jawi I P G. Adiatmika Moh. Ali Imron Mujaddid Idulhaq Suci Muqodimatul