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All Journal The Journal of Experimental Life Sciences (JELS) ARSHI Veterinary Letters Journal of Applied Veterinary Science and Technology
Ajeng Erika Prihastuti Haskito
Laboratorium Kesehatan Masyarakat Veteriner, Fakultas Kedokteran Hewan, Universitas Brawijaya, Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Veterinary

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Journal : Journal of Applied Veterinary Science and Technology

 1 
Literature Study: Leptospirosis in Dogs 2012-2021 Period Muhammad Fahmi Al Rasyid; Ajeng Erika Prihastuti Haskito; Dodik Prasetyo; Agri Kaltaria Anisa
Journal of Applied Veterinary Science And Technology Vol. 4 No. 1 (2023): April 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V4.I1.2023.52-60

Abstract

Background: Leptospirosis is a zoonotic disease caused by Leptospira interrogans and infects almost all mammals. Purpose: Finding out the correct diagnosis and choosing the best treatment outcome regarding clinical symptom recovery and confirmatory investigations. Method: This literature study compared the percentage of related parameters from 18 cases and discussed 18 cases of dogs infected with leptospirosis with international coverage. Based on the literature, methods for diagnosing leptospirosis in dogs include anamnesis, clinical symptoms, abnormal clinical pathology findings, serological tests such as the Microscopic Agglutination Test (MAT), and molecular diagnostics such as Polymerase Chain Reaction (PCR). Results: Dominant clinical symptom in the digestive system was vomiting (55%), whereas the consistent hematological finding was thrombocytopenia (55.5%), and the consistent blood chemistry finding was elevated BUN (66.6%). Most case studies used the molecular diagnostic method MAT which found positive results (55.5%). Therapeutic management carried out in the case studies included causative treatment of antibiotics (doxycycline, benzylpenicillin, amoxicillin, and enrofloxacin), fluid therapy (crystalloids), antioxidants (vitamin C), mucolytics (N-acetylcysteine), and antiemetics (metoclopramide). The number of patients declared cured was 44.5%, and 55.5% died. Conclusion: The predominant clinical symptoms of leptospirosis are categorized as non-specific, with the largest number being vomit. The dominant method of diagnosis of leptospirosis was obtained from 16 cases using hematology and blood chemistry tests. The therapy is given causatively, namely doxycycline antibiotics, whereas symptomatic signs are resolved using metoclopramide as an antiemetic.
Kidney and Ileum Histopathology of Rattus norvegicus Toxicity Model of Rhodamine B and Saccharin Supplemented with Purple Roselle Yoghurt Dzakiyyah Salmaa; Ajeng Erika Prihastuti Haskito; Anna Safitri; Aldila Noviatri; Handayu Untari; Citra Sari
Journal of Applied Veterinary Science And Technology Vol. 4 No. 2 (2023): October 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V4.I2.2023.105-114

Abstract

Background: Rhodamin B and saccharin are chemicals that are harmful to the health of the body. Consumption of rhodamine B and saccharin for a long time can cause problems for the body such as impaired organ function. Purpose: The aim was to find out the benefits of giving purple rosella yogurt in preventing damage to the kidneys and ileum of Rattus norvegicus caused by rhodamine B and saccharin. Methods: Using RAL with 28 male Rattus novergicus aged 8-12 weeks. Group K(-) was not given any treatment, K(+R) was given rhodamine B, K(+S) was given saccharin, K(+K) was given rhodamine B and saccharin, P1 was given rhodamine B and yoghurt, P2 was given saccharin and yoghurt, P3 was given rhodamine B, saccharin, and yogurt. The dose of rhodamine B was 22.5 mg/kg, the dose of saccharin was 157.7 mg/kg, the volume of yoghurt was 1 ml/head. Administered orally with gastric tube for 14 days. The concentration of purple rosella extract used was 15% (v/v). Results: Group K(+K) showed the heaviest damage. Groups P1, P2, and P3 still found damage to the kidneys, in P1 they experienced thickening of Bowman's capsule in the glomerulus, in P2 they experienced a loss of more than 25% of the brush border in the tubules, and in P3 they experienced glomerular tufts in the glomerulus. In the ileum, P1 experienced thickening of the muscles, P2 experienced clusters of inflammatory cells in the submucosa, and P3 experienced 10-50% loss of goblet cells. Conclusion: Provision of purple rosella yogurt can prevent damage to the kidneys and ileum of Rattus novergicus due to rhodamine B and saccharin, although it is not optimal.
Co-Authors Adik Putri Fatma Hariono Agri Kaltaria Anisa Aldila Noviatri Ani Setianingrum Dameanti, Fidi Nur Aini Eka Puji Dodik Prasetyo Dzakiyyah Salmaa Handayu Untari Herlina Pratiwi Ida Bagus Gede Rama Wisesa Iffa Fanadila M. Fadli Muhammad Fahmi Al Rasyid Purnamasari, Citra Reza Yessica Safitri, Anna