Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Molecular and Cellular Biomedical Sciences (MCBS) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Marshel Tendean
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Neuroscience

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Molecular and Cellular Biomedical Sciences (MCBS)

 1 
Cardiomyocyte Reprogramming: A Potential Strategy for Cardiac Regeneration Tendean, Marshel; Oktaviono, Yudi Her; Sandra, Ferry
Molecular and Cellular Biomedical Sciences Vol 1, No 1 (2017)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v1i1.5

Abstract

Heart disease is the leading cause of death worldwide. Within decades a limited process of cardiac cell regeneration was under observation. Embryonic stem cell (ESC) shows great potential for cell and tissue regeneration. Studies indicate that ESC has the potential to enhance myocardial perfusion and/or contractile performance in ischemic myocardium. However there is still challenge to evaluate the issues of teratoma. Then induced pluripotent stem cell was invented by introducing four transcriptional factors (Oct4, Sox2, Klf4, c-Myc). iPSC was created from murine fibroblast and then differentiated into cardiomyocyte. Reprogramming the adult cell could be performed in full, partial or direct reprogramming. Several studies add the significance by reprogramming the cells through more efficient techniques. However several limitations are still remained.Keywords: cardiomyocyte, reprogramming, iPSC, fibroblast
Co-Authors Cecep Kusmana Fendra Wician Fendra Wician Ferry Sandra Ivan DP Sunardi Mardi Santoso Suzanna Ndraha Yudi Her Oktaviono, Yudi Her