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All Journal Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam JURNAL PHOTON
H. Y. Teruna
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Chemistry Mathematics Nursing Physics

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SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN 3,5-BIS((E)-METOKSI BENZILIDEN)-1-(FENILSULFONIL)-PIPERIDIN-4-ON Rahmawati, E. N.; Teruna, H. Y.; Zhamri, A.
Sistem Informasi Vol 9 No 1 (2018): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

 A study has been conducted to synthesize analog of curcumin with base catalyzed condensation of 4-piperidone hydrochloride with substituted benzaldehyde under reflux led the formation of mono-carbonyl curcumin. The synthesized curcumin were further reacted with benzosulphonyl chloride by nucleophilic substitution of –NH group to afford 3,5-bis((E)-2-metoksi benziliden)-1-(fenilsulfonil)piperidin-4-on (EN-BS) compounds with excellent yield, 94%. Structure of the synthesized compounds were confirmed by UV, IR, MS and NMR spectra analysis. All the synthesized compounds were screened for their toxicity activity using BSLT method. The result showed that compounds are toxic whereas the LC50 is below 200 ppm.
IDENTIFIKASI DAN UJI TOKSISITAS EKSTRAK METANOL DARI DAUN TANAMAN SIRSAK (Annona muricata L) R. Juliani; Yuharmen '; H. Y. Teruna
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Soursoup (Annona muricata L) was used in herbal medicine. This Annonaceae familymember contains alkaloids, tannins, and several other chemical constituents, includingasetogenin that allegedly to have cytotoxic potential. The n-hexane and methanolmacerating method was applied to isolate the secondary metabolites from the stem barkof this plant. The separation was carried out by vacuum liquid chromatography (VLC),column chromatography, and gel chromatography respectively. Characterization of thefractions was established using UV-Vis and FTIR spectrophotometry. Toxicity assaywas conducted by Brine Shrimp Lethality Test (BSLT) method. The LC 50 of 3 rd to 11 thfractionts of the methanol extract wer 4481.25; 37; 11.46; 0.85; 3.02; 0.23; 10.97; 8.53and 4093 ppm, respectively. The 3 rd and 11 th fractionts were not toxic, whereas otherfractions were toxic and potential to be used as an anticancer.
Co-Authors R. Juliani Rahmawati, E. N. Yuharmen ' Zhamri, A.