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All Journal Walisongo Journal of Chemistry Jurnal Katalisator
Indah Permata Yuda
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Agriculture, Biological Sciences & Forestry Chemistry

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Metabolit Sekunder dari Kulit Batang Kalesi (Sphatolobus Ferrogenus) Serta Uji Inhibitor Enzim A-Glukosinade Moch Abdussalam; Indah Permata Yuda; Juniarti Juniarti
Walisongo Journal of Chemistry Vol 4, No 1 (2021): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v4i1.7991

Abstract

Tanaman herbal merupakan warisan kearifan lokal dalam upaya pengobatan dan mempertahankan kesehatan masyarakat. Secara tradisional masyarakat Kalimantan tengah menggunakan tanaman aka kalesi (Sphatolobus ferrogenus) sebagai obat-obatan tradisional yang cukup luas. Penelitian ini bertujuan untuk mengisolasi senyawa metabolit sekunder yang terdapat dalam ekstrak metanol kulit batang aka kalesi (Sphatolobus ferrogenus). Isolasi dilakukan dengan tahapan ekstraksi, fraksinansi dan purifikasi. Hasil penelitian didapatkan dua isolat yang telah diuji kemurniannya dengan metode kromatografi lapis tipis. Isolat diidentifikasi dengan spektroskopi 1H-NMR dan 13C-NMR didapatkan senyawa gliseril monostearate dan sigmasterol. Kedua senyawa diuji sifat antidiabetes dengan metode inhibitor enzim α-glukosidase. Aktivitas senyawa gliseril monostearate tidak aktif, sementara sigmasterol menunjukan aktivitas yang lemah dengan IC50= 388 ppm.
ISOLATION OF ANTIOXIDANT COMPOUNDS FROM KEBIUL (CAESALPINIA BONDUC L) SEED SHELLS Mohd Abdus salam; Indah Permata Yuda; Juniarti
JURNAL KATALISATOR Vol. 11 No. 1 (2026): Jurnal Katalisator, Volume 11 No 1 April 2026
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/yyx6jb26

Abstract

Caesalpinia bonduc L. is a medicinal plant widely distributed in tropical and subtropical regions and has long been utilized in traditional medicine for the treatment of various ailments. Its seeds are recognized as a rich source of bioactive secondary metabolites, particularly flavonoids, phenolic compounds, terpenoids, and diterpenes, which have been associated with antioxidant, anti-inflammatory, antimicrobial, and antidiabetic activities. However, studies focusing on the isolation, purification, and characterization of individual bioactive compounds from C. bonduc seeds remain limited. Therefore, this study aimed to isolate, purify, identify, and evaluate the antioxidant activity of bioactive compounds obtained from C. bonduc L. seeds. Bioactive compounds were isolated from the seed extract through successive extraction, chromatographic separation, and purification procedures. The purified compound was subsequently characterized by phytochemical identification and evaluated for its free radical scavenging activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The isolated compound was identified as a flavonoid based on its chemical characteristics. Antioxidant evaluation demonstrated that the isolated flavonoid exhibited potent free radical scavenging activity, with a half-maximal inhibitory concentration (IC₅₀) of 3.31 ± 0.12 µg/mL, indicating a very strong antioxidant capacity. The findings demonstrate that C. bonduc seeds constitute a valuable source of naturally occurring antioxidant compounds and support their traditional medicinal use.  
Co-Authors Juniarti Juniarti . Moch Abdussalam Mohd Abdus salam