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All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Indonesian Journal of Biomedicine and Clinical Sciences
Rosa De Lima Renita Sanyasi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Perbaikan Gejala Neuropati Pada Pemberian Kombinasi Vitamin B Untuk Pasien Neuropati Diabetikum Rizaldy Taslim Pinzon; Rosa De Lima Renita Sanyasi
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 15 No. 02 Desember 2018
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (788.726 KB) | DOI: 10.30595/pharmacy.v15i2.3482

Abstract

Neuropati diabetikum (ND) adalah komplikasi utama yang sering muncul pada pasien diabetes mellitus (DM). Penelitian ini bertujuan untuk menilai efektivitas vitamin B kombinasi terhadap gejala klinis ND dan QoL (kualitas hidup/quality of life) pada pasien DM. Metode yang digunakan dalam penelitian ini adalah metode penelitian one group pre and post test design pada pasien DM dengan ND. Setiap subjek mendapatkan kombinasi vitamin B yang terdiri dari: vitamin B1, vitamin B6, dan vitamin B12 dengan dosis masing-masing secara berurutan: 100 mg, 100 mg, 5000 mcg. Gejala klinis ND diukur dengan menggunakan Total Symptom Score (TSS). Angka QoL diukur dengan menggunakan kuesioner SF-8. Penilaian gejala dilakukan sebanyak 5 kali, dari penilaian awal hingga 3 bulan. Ada 104 subjek pada awal penelitian. Tujuh subjek tidak dapat mengikuti penelitian sampai selesai, sehingga tersisa 97 subjek pada akhir penelitian. Ada perbaikan gejala ND, yang meliputi sensasi nyeri tertusuk, sensasi nyeri terbakar, kesemutan, dan rasa kebas/baal, setelah pemberian kombinasi vitamin B. Perubahan tersebut bermakna secara statistik (p<0,0001). Hasil serupa juga tampak pada QoL. Ada perbaikan QoL dari awal penelitian hingga akhir penelitian. Perbedaan tersebut bermakna secara statistik (physical component summary dengan p<0,0001 dan mental component summary dengan p=0,0001). Kombinasi vitamin B efektif untuk memperbaiki gejala klinis dan meningkatkan kualitas hidup pada pasien ND.
The clinical outcomes and quality of life in patients with Guillain- Barré syndrome: a literature review Rosa De Lima Renita Sanyasi
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.19134

Abstract

Guillain-Barre syndrome (GBS) is an immune-mediated condition that targets the roots of the spinal cord and peripheral nerves. While most patients with GBS can achieve complete recovery with appropriate management, some may experience long-term sequelae that adversely impact their quality of life (QoL). Clinical outcomes are measured variables in research to evaluate the effects of interventions or exposures on a particular population’s health. Patients with GBS may experience suboptimal clinical outcomes due to post-GBS disabilities, which may result from complications or residual symptoms of the syndrome. These disabilities can impede daily functioning and significantly lower QoL, often requiring patients to alter their lifestyles, work, and social interactions. Quality of life is a subjective assessment of how individuals perceive their circumstances in relation to their goals, influenced by their cultural and value systems. Various tools are available to assess the quality of life for GBS patients. The clinical outcomes and QoL for post-GBS patients are diverse and shapedby various factors. Through the early identification of these factors, clinicians can enhance management strategies to improve both clinical outcomes and the overall QoL for individuals recovering from GBS.
Co-Authors Rizaldy Taslim Pinzon