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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Borneo Journal of Pharmacy
Rizaldy Taslim Pinzon
Duta Wacana Christian University
Health Professions Materials Science & Nanotechnology Medicine & Pharmacology

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Dampak Pemberian Vitamin B1, B6, B12 Parenteral terhadap Proporsi Hiperhomosisteinemia pada Pasien Hemodialisis Rizaldy Taslim Pinzon; Kiki Amelia
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (870.958 KB) | DOI: 10.30595/pharmacy.v17i1.4858

Abstract

Banyak pasien gagal ginjal kronis menderita hiperhomosisteinemia yang dapat meningkatkan risiko terjadinya penyakit vaskuler. Dari penelitian sebelumnya ditemukan bahwa pemberian vitamin B dapat mengurangi hiperhomosisteinemia pada pasien yang menjalani hemodialisis. Penelitian ini dilakukan untuk mengukur dampak pemberian vitamin B1, B6, B12 parenteral terhadap proporsi hiperhomosisteinemia pasien gagal ginjal kronik yang menjalani hemodialisis. Penelitian dilakukan dengan desain one group pretest-posttest menggunakan data sekunder rekam medis hasil laboratorium. Data didapatkan dari 117 pasien dengan metode consecutive sampling dan analisis data dilakukan menggunakan SPSS berlisensi dengan uji McNemar. Hasilnya terdapat penurunan proporsi hiperhomosisteinemia yang bermakna setelah pemberian vitamin B selama 2 minggu (70,94%; p=0,000) dan 4 minggu (66,38%; p=0,000), sehingga kesimpulannya, pemberian vitamin B1, B6, dan B12 dalam jangka waktu 2 minggu maupun 4 minggu dapat menurunkan proporsi hiperhomosisteinemia secara bermakna pada pasien gagal ginjal kronis yang menjalani hemodialisis.
Characteristic of Red Blood Cell Profile as a Predictor of 30-Day Clinical Outcome in Ischemic Stroke Patients Nathania Fadjarsugeng; Rizaldy Taslim Pinzon; Sugianto Sugianto
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4055

Abstract

Ischemic stroke is the most common type of stroke in Indonesia. Measuring inflammatory biomarkers (IL-6) is a way to predict clinical outcomes in ischemic stroke patients. However, the laboratory test is very expensive, so it requires another test that can represent the inflammation, for instance, by measuring RDW and MCV value when hospitalized. Hence, this study aims to measure RDW and MCV value of ischemic stroke patients at admission with a 30-day clinical outcome (disability). This study is a retrospective cohort that used secondary data from medical records of ischemic stroke patients in Bethesda Hospital Yogyakarta and was conducted on 105 subjects. They are divided into two groups by their mRS score in 30-day after onset, (1) the independent group (mRS score of 0- 2), (2) the dependent group (mRS score of 3-6). After that, these two groups are analyzed by an independent t-test. High RDW and low MCV value at admission increased 30-day disability risk. There was a statistically significant RDW value and 30-day clinical outcome (p=0,008), but there was no statistically significant MCV value and 30-day clinical outcome (p=0,277). 30-day clinical outcome in ischemic stroke patients can be predicted by their characteristic of red blood cell profile at admission.
Effects of Switching Dose, Dose Variation, and Warfarin Interaction on the Incidence of Stroke Recurrence in Stroke Patients with Atrial Fibrillation Lailla Affianti Fauzi; Erna Kristin; Rizaldy Taslim Pinzon; Bernadeta Margareta Wara Kushartanti; Novita Intan Arovah
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6603

Abstract

Atrial fibrillation (AF) significantly increases the risk of stroke, necessitating anticoagulation therapy. Warfarin, a commonly prescribed anticoagulant regimen, requires careful monitoring to ensure patient safety. This study aimed to assess the impact of dose switching, dose variation, and potential interactions with warfarin on the incidence of stroke recurrence in stroke patients with AF. The study retrospectively analyzed the treatment records of stroke patients with AF in outpatient settings over one year. The subjects comprised 314 patients who received warfarin prescriptions at two Indonesian Hospitals from January 1, 2015, to December 31, 2019. Out of these patients, 50 had recorded data regarding dose adjustments, variations, and interactions. They were divided into two groups: a case group (n=11) with stroke recurrence and a control group (n=39) without recurrence. Statistical analysis, including chi-square tests and odds ratio calculations, revealed that both warfarin dose switching (OR=7.6) and dose variation (OR=6.6) significantly influenced the incidence of stroke recurrence. It implies that inconsistencies or alterations in warfarin dosing substantially elevate the likelihood of experiencing another stroke, potentially due to inadequate anticoagulation leading to clot formation. Interestingly, the analysis of drug interactions did not significantly impact stroke recurrence. In summary, the recurrence of stroke in patients with AF is notably influenced by warfarin dose adjustments and variations rather than drug interactions. This study highlights the critical importance of precise dosing strategies and vigilant monitoring to enhance the efficacy of anticoagulant therapy in this high-risk population.
Co-Authors Bernadeta M Wara Kushartanti Erna Kristin Kiki Amelia Lailla Affianti Fauzi Nathania Fadjarsugeng Novita Intan Arovah Sugianto Sugianto