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All Journal JAFP (Jurnal Akademi Farmasi Prayoga)
Nadya Fitri Handayani
Sekolah Tinggi Farmasi Indonesia Perintis Padang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Aplikasi Etil Selulosa sebagai Polimer pada Formulasi Mikrokapsul Papain dengan Metode Penguapan Pelarut Yahdian Rasyadi; Farida Rahim; Nadya Fitri Handayani
Jurnal Akademi Farmasi Prayoga Vol 4 No 1 (2019): Jurnal Akademi Farmasi Prayoga
Publisher : Jurnal Akademi Farmasi Prayoga

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Abstract

Papain is an enzyme obtained from the sap of papaya which has proteolytic power, easily damaged by air both during manufacture and storage. This study aims to see whether microencapsulation of papain using ethyl cellulose by solvent evaporation method can protect papain from damage. Papain microcapsules are made with papain and ethyl cellulose polymers with their respective ratios F1 (1:1), F2 (1:2), F3 (1:3) using solvent evaporation methods. Evaluation of papain microcapsules with ethyl cellulose as a polymer includes organoleptis, particle size average, % recovery, surface morphology of microcapsules using Scanning Electron Microscope (SEM). From the evaluations of organoleptic F1, F2, and F3, three formulas were formed in the form of crystalline powder, yellowish white, distinctive smell. Particle size average of F1; F2; and F3 each of which is 14.68 µm; 42.84 µm; and 70.98 µm. Recovery from F1, F2, and F3 were 85.50%, 93.24% and 95.50% respectively. The results of SEM showed that ethyl cellulose had covered the surface of papain in F1, F2, and F3. The particle size and % recovery show that F3 is the best formula. Papain microencapsulation using ethyl cellulose by solvent evaporation method can provide protection against papain from damage.
FORMULASI KRIM DARI MIKROKAPSUL PAPAIN Rahdian Rasyadi; Yahdian Rasyadi; Farida Rahim; Nadya Fitri Handayani
Jurnal Akademi Farmasi Prayoga Vol 5 No 1 (2020): Jurnal Akademi Farmasi Prayoga Padang
Publisher : Jurnal Akademi Farmasi Prayoga

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Abstract

Telah dilakukan penelitian tentang formulasi krim dari mikrokapsulas papain. Tujuan penelitian ini adalah untuk dapat memformulasi mikrokapsul papain dalam bentuk sediaan krim dan evaluasi fisik sediaan. Krim mikrokapsul papain dibuat dengan menggunakan basis vanishing cream. Evaluasi fisik yang dilakukan pada krim mikrokapsul papain antara lain Uji organoleptis, uji homogenitas, pengukuran pH, uji kestabilan fisik, uji tipe krim, dan uji iritasi. Hasil pengamatan organoleptis menunjukkan bahwa krim berbentuk setengah padat, warna putih, tidak berbau, homogenitasnya tidak homogen, pH rata-rata 6,21, uji stabilitas krim menggunakan metode freeze and thaw menunjukan bahwa krim mikrokapsul papain stabil dalam suhu rendah maupun tinggi, tipe krim (m/a), uji iritasi krim yang dilakukan langsung pada kulit panelis selama 72 jam menunjukkan bahwa krim mikrokapsul papain tidak mengiritasi terhadap kulit. Hasil evaluasi fisik krim menunjukan bahwa mikrokapsul papain bisa diformulasi menjadi sediaan krim.
Co-Authors Farida Rahim Rahdian Rasyadi Yahdian Rasyadi