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Comparison of Central Corneal Thickness and Lamina Cribrosa Thickness in Ethnic Indians and Ethnic Malays as Predictors of Glaucomatous Optic Neuropathy Meironi Waimir; Andrini Ariesti; Ardizal Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.655

Background: Glaucoma poses a public health problem because it is the second leading cause of blindness after cataracts. A thinner central corneal thickness (CCT) is also a contributor to the development of primary open-angle glaucoma (POAG). Lamina cribrosa (LC) is a structure of the optic nerve head (ONH). LC structural changes such as thinning, posterior displacement, and connective tissue deficiency are associated with the mechanism of retinal nerve fiber layer (RNFL) thickness damage, leading to glaucomatous optic neuropathy. Methods: Cross-sectional analytic observational study. A total of 36 eyes from 36 research subjects participated in this study. Data analysis was carried out using SPSS version 25. Then, univariate and bivariate analyzes were carried out to see the difference in CCT and LC thicknesses. Results: The average CCT in ethnic Indians is 514.33 ± 14,142 μm and in ethnic Malays, 542.06 ± 17,234 μm. In this study, there were differences in the average CCT in Indian ethnicity and Malay ethnicity, which was statistically meaningful with a p-value = 0.000. Conclusion: There are differences in the average central corneal thickness and lamina cribrosa thickness in ethnic Indians compared to ethnic Malays, where the central corneal thickness and lamina cribrosa thickness in ethnic Indians are thinner than ethnic Malays.

Overview of Bilateral Retinoblastoma at Dr. M. Djamil General Hospital, Padang, Indonesia Ficky Ferliando; Ardizal Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.699

Background: Retinoblastoma is the most common intraocular primary malignant tumor in children. In the United States, cases of retinoblastoma are estimated to be found in 1 in 18,000 children under 5 years. The incidence of retinoblastoma ranges from 1:14.00 to 1:34.000 live births. The highest incidence occurs in developing countries. This study aimed to provide a clinical picture of bilateral retinoblastoma at Dr. M. Djamil General Hospital, Padang, Indonesia, as basic data for further policy-making in order to optimize services related to the management of bilateral retinoblastoma. Methods: This study was a descriptive observational study with 29 study subjects. Sociodemographic, clinical, and management data are presented descriptively. Data analysis was performed with the help of SPSS software version 25. Results: Based on the age group, the majority of bilateral retinoblastoma cases were less than 5 years old, with the most age range being 3-4 years. The majority of therapeutic management for cases of bilateral retinoblastoma is exenteration in combination with chemotherapy. Conclusion: A combination of surgery and chemotherapy is the most frequently used treatment for bilateral retinoblastoma at Dr. M. Djamil General Hospital, Padang, Indonesia.

Kombinasi Injeksi Triamsinolon Asetat Intralesi dan Propanolol Oral pada Kasus Hemangioma Kapiler Palpebra Mardijas Efendi; Hendriati Hendriati; Ardizal Rahman; Muhammad Fadhil Rahmadiansyah
Jurnal Kesehatan Andalas Vol 11, No 2 (2022): Online July 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.2082

Capillary hemangioma is a benign tumor developed from the abnormal proliferation of blood vessels. This tumor appears on eyelids and orbit. Around 75% of hemangioma resolves spontaneously in the first 4-5 years of life. Intervention is needed in hemangioma that obstructs the visual axis. It has been reported that a two-year-old girl came to Polyclinic with a mass on the left superior eyelid 1,5 years ago. At first, the left superior eyelid looked puffy, then developed slowly until it covered the left eye. On the examination of the left eye, visual acuity assessment was hard to perform. Mass in superior palpebral was 8mm x 8mm x 8mm, reddish colored (different with adjacent skin), consistency supple, mobile, painful (-), edema (+), horizontal palpebral fissure (FPH) 30 mm, vertical palpebral fissure (FPV) 0 mm. CT scan showed suspected hemangioma. The patient was diagnosed with capillary hemangioma and given an injection of triamcinolone acetate intralesional and oral propranolol under the supervision of a pediatrician. Significant clinical improvement was observed after 40 days of injection, where the mass was resolved completely. The FPV and FPH of the left eye had improved to 9 mm and 30 mm, respectively, with the patient finally able to follow the object. The combination of intralesional triamcinolone acetate and oral propranolol in this case is quite effective in providing complete resolution of capillary hemangioma.Keywords: capillary hemangioma, triamcinolone acetate injection, propanolol

The Profile of Ocular Fibrous Histiocytoma Tumors at Dr. M. Djamil General Hospital, Padang, Indonesia Eka Alpasra; Ardizal Rahman; Mardijas Efendi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.716

Background: Ocular fibrous histiocytoma tumors originate from histiocytic cells or primitive mesenchymal cells. A fibrous histiocytoma is basically composed of a mixture of fibroblastic cells, histiocytes, blood vessels, and collagen in various proportions. This study aimed to determine the profile of ocular fibrous histiocytoma tumors at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study was a descriptive observational study. A total of 8 research subjects participated in this study. Data analysis was carried out with the help of SPSS version 24 software, and univariate analysis was carried out. Results: The majority of subjects were female, with an age range of 41-60 years. The clinical symptoms felt by patients are the presence of a mass. The majority of study subjects had disease onset < 6 months, and tumor sizes were 1-5 cm. The majority of tumor locations are on the eyelid, and the histopathologic overview shows xanthelasma and dermatofibromas. Excision therapy is the therapy for the majority of research subjects. Conclusion: Most types of fibrous histiocytoma tumors at Dr. M. Djamil General Hospital, Padang, Indonesia, are benign type and locally aggressive.

The Profile of Ocular Fibrous Histiocytoma Tumors at Dr. M. Djamil General Hospital, Padang, Indonesia Eka Alpasra; Ardizal Rahman; Mardijas Efendi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.716

Background: Ocular fibrous histiocytoma tumors originate from histiocytic cells or primitive mesenchymal cells. A fibrous histiocytoma is basically composed of a mixture of fibroblastic cells, histiocytes, blood vessels, and collagen in various proportions. This study aimed to determine the profile of ocular fibrous histiocytoma tumors at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study was a descriptive observational study. A total of 8 research subjects participated in this study. Data analysis was carried out with the help of SPSS version 24 software, and univariate analysis was carried out. Results: The majority of subjects were female, with an age range of 41-60 years. The clinical symptoms felt by patients are the presence of a mass. The majority of study subjects had disease onset < 6 months, and tumor sizes were 1-5 cm. The majority of tumor locations are on the eyelid, and the histopathologic overview shows xanthelasma and dermatofibromas. Excision therapy is the therapy for the majority of research subjects. Conclusion: Most types of fibrous histiocytoma tumors at Dr. M. Djamil General Hospital, Padang, Indonesia, are benign type and locally aggressive.

Pediatric Primary Orbital Tumors in Dr.M. Djamil General Hospital Padang Elfi Risalma; Ardizal Rahman
Majalah Oftalmologi Indonesia Vol 43 No 2 (2017): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v43i2.153

Introduction : Primary orbital tumors of childhood are different from tumors that occur in adults. Many are congenital with early presentation. In pediatric population, a delay in diagnosis of orbital tumors , even benign tumor can lead to vision loss and deformity. Objective : To report pediatric primary orbital tumors in Dr.M.Djamil Hospital Padang. Method : A retrospective study of orbital tumors in pediatric patients admitted to DR.M.Djamil Hospital between 2003- 2016. Data were obtained from medical records which described patients characteristics based on type, sex,presentation, and management. Result : There were 36 patients of pediatric primary orbital tumors which consist of 20 boys and 16 girls, diagnosis based onclinical sympoms, CT-Scan and pathological examination. The most common tumors in pediatric was Rhabdomyosarcoma in 11 patients (30,55%), Glioma of the Optic nerve in 8 patients (22.22%), Limphoma Malignum in 5 patients (13.88%), Capillary Hemangiomas in 2 patients (5.55%), Cavernous Hemangioma in 2 patients (5.55%), AV Malformation in 2 patients (5.55%), Meningioma in 1 patient (2.77%), Neurofibromatosis in 1 patient (2.77%), Neurilemomoa in 1 patient (2.77%), Limfohemangioma in 1 patient (2.77%), osteoma in 1 patient (2.77%) and Adenoid Cystic Carcinoma in 1 patient (2,94%). Surgery had been performed in 11 patients (30.55%), chemotherapy in 7 patients (19.44%), radiotherapy in 1 patient (2,77%), Combination therapy in 2 patient (5.55%), medical therapy in 1 patient (2.77%) and the remains 14 patients (38.89%) were observed. Conclusion : There were 36 cases pediatric orbital tumors during 14 years. The most common tumor was Rhabdomyosarcoma. Management of pediatric orbital tumors consists of surgery, chemotherapy, radiotherapy and combination therapy.

Manifestasi Klinis Okular dan Orbital pada Penyakit Sinus Paranasal dan Manajemennya di RS Dr. M. Djamil Padang Muhammad Syauqie; Ardizal Rahman
Majalah Oftalmologi Indonesia Vol 45 No 2 (2019): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v45i2.190

Latar belakang : Hubungan yang erat antara penyakit sinus paranasal dan orbita disebabkan karena letaknya yang berbatasan secara anatomis. Sekitar 60% hingga 80% dari dinding orbita tersusun dari dinding sinus paranasal. Pasien dengan penyakit sinus paranasal dapat memperlihatkan gejala okular yang lebih menonjol tanpa disertai gejalai rhinologik yang nyata. Tujuan penelitian ini yaitu untuk mendeskripsikan gejala okular yang khas pada pasien dengan penyakit sinus paranasal menurut etiologi yang mendasarinya. Metode : Penelitian retrospektif dari rekam medis dari bulan Januari 2008 - Desember 2017. Data yang dikumpulkan berupa umur, jenis kelamin, diagnosa penyakit sinus paranasal, sinus yang terlibat, ada tidaknya invasi orbita dan gejala klinis okular. Hasil : Terdapat 55 pasien yang berobat ke poliklinik rawat jalan bagian oftalmologi RSUP Dr. M. Djamil Padang selama periode tahun 2008-2017, baik datang secara langsung atau dikonsulkan dari bagian THT-KL, dengan kecurigaan invasi orbita akibat penyakit sinus paranasal, yang terdiri dari 34 (61.8%) laki-laki dan 21 (38.2%) perempuan. Usia pasien bervariasi dari umur 4 tahun hingga 83 tahun, dengan kelompok umur terbanyak antara umur 51 hingga 60 tahun. Invasi orbita terjadi pada 45 pasien (81.8%) dan disebabkan oleh tumor sinonasal pada 35 pasien (77.7%), oleh infeksi sinus pada 8 pasien (17.7%) dan oleh mukokel pada 2 pasien (4.6%). Tumor sinonasal merupakan penyakit sinus paranasal terbanyak yaitu pada 43 pasien (78.2%) dan sinus maksilaris merupakan sinus yang terbanyak terlibat. Mayoritas pasien (67.7%) datang dengan presentasi klinis proptosis, diikuti dengan oftalmoplegia (54.8%) dan penurunan visus (43.5%). Kesimpulan: Tumor sinonasal merupakan etiologi terbanyak abnormalitas orbita akibat invasi penyakit sinus paranasal dan sinus maksilaris merupakan sinus yang terbanyak terlibat. Proptosis merupakan manifestasi klinis okular terbanyak sebagai komplikasi orbita yang disebabkan penyakit sinus paranasal. Proptosis bersifat nonaksial dan arah proptosis berlawanan dengan letak sinus yang terlibat

The Profile of Sinonasal Tumors with Orbital Involvement in Dr. M. Djamil General Hospital, Padang, Indonesia: A 10-Year Overview Dwi Lestari Pohan; Ardizal Rahman; Mardijas Efendi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 6 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i6.1014

Background: Sinonasal tumors are rare tumors, either malignant or benign, that vary greatly based on the origin and primary tumor location in the sinonasal tract. The close anatomical relationship between the sinonasal tract and the orbital cavity makes orbital involvement very common (50%-80%) in sinonasal tumors, and this indicates a negative prognostic factor in sinonasal malignancy. The purpose of this study is to demonstrate the profile of sinonasal tumors with orbital involvement in our center. Methods: Retrospective study from oncology subdivision files and medical records from January 2011 – December 2020. Collected data including age, gender, the clinical manifestations of orbital involvement, primary location, histopathology, and management of sinonasal tumors. Results: There were 35 patients examined by the oncology subdivision either directly came or consulted from the ENT department, consisting of 18 (51.4%) males and 17 (48.6%) females. The age of patients ranged from 11 to 83 years old. with the most common age groups being 41-50 and 51-60 (25.7% in each age group). The majority of the patients (77.1%) had presented with proptosis. Maxillary sinus was the most common (45.7%) primary site of tumors, and squamous cell carcinoma was the most common (51.4%) histopathology found. Most of the patients (37.1%) were treated with a combination of chemotherapy and radiotherapy. Conclusion: Orbital involvement commonly occurs in malignant sinonasal tumors with proptosis as a major clinical presentation. A combination of chemotherapy and radiotherapy was the most common practice management because the tumors were unresectable at the time of presentation.

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