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Mansur Mohammed Birnin Kebbi
Usmanu Danfodiyo University Teaching Hospital, Sokoto
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar Rats Muhammad Bashiru AbdulRahman; Yusuf Gumburawa Malami; Sanusi Wara Hassan; Mansur Lawal; Waliu Temitope Adanlawo; Mansur Mohammed Birnin Kebbi; Kamaldeen Olalekan Sanusi
Biology, Medicine, & Natural Product Chemistry Vol 11, No 1 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.111.83-87

Abstract

Medicinal plants have protective effect because of the presence of several compounds which have different mechanism of action. This study sought to assess the anti-oxidative effects of butanol seed extract of Parkinsonia aculeata on carbon tetrachloride (CCl4)-induced liver damage on Wistar rats. The Wistar rats were put into five groups, each with six rats: Group A received a daily dosage of liquid paraffin (1ml/kg); Group B received 1ml/kg body weight of CCl4 (30% in liquid paraffin intraperitoneal); Group C, D, and E received the seed extracts at 100, 120, and 160 mg/kg every day for two weeks. Induction of CCl4 was three times a week for two weeks simultaneously with the extract to the last day. After sacrificed, the liver was harvested and homogenized, and used for further analyses. There was a significant increase (p<0.05) in the levels of superoxide dismutase and catalase in all extract treated groups compared to positive control, except the catalase levels of group treated with 160mg/kg. Similar results was observed in vitamin C, vitamin E and glutathione in rats treated with 100 and 120mg/kg of the extract. The results of this study revealed that butanol seed extract from P. aculeata has antioxidant properties and can protect Wistar rats' livers from the damaging effects of CCl4.
Co-Authors Kamaldeen Olalekan Sanusi Mansur Lawal Muhammad Bashiru AbdulRahman Sanusi Wara Hassan Waliu Temitope Adanlawo Yusuf Gumburawa Malami