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Achmad Hussein Sundawa Kartamihardja
Nuclear Medicine and Theranostic Molecular Department, Hasan Sadikin General Hospital
Health Professions Medicine & Pharmacology

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DETEKSI KEBOCORAN CAIRAN LIQUOR DENGAN PEMERIKSAAN SPECT/CT SISTERNOGRAFI RADIONUKLIDA Kharisma Perdani Kusumahstuti; David Siahaan; Rian Hidayatullah; Achmad Hussein Sundawa Kartamihardja
Unram Medical Journal Vol 11 No 2 (2022): vol 11 no 2 2022
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i2.713

Abstract

Radionuclide cisternography is often used to prove the presence of cerebrospinal fluid leakage from the nose or ears and to localize the location of the leak. Whether the leak is active or not at the time of examination greatly affects the results of the radionuclide examination. We report a rare study case in a female patient 56 years old, who had the main complaints of nasal discharge, apathy, and weakness. The discharge is mainly felt when the patient is sitting. The patient had a history of transsphenoidal surgery for removal tumor at the epiphyses. Cisternography examination was carried out at the Department of Nuclear Medicine and Molecular Theranostic to confirm a liquor leak in the patient. Imaging was performed at 1.3.6 hours after intrathecal 99mTc-DTPA injection. There is an increase in radioactivity in the nasal area, especially on the 3 hour image. SPECT / CT fusion imaging provides the exact location of the liquor leak at the sphenoid area. The nasal tampon to blood serum ratio is 4: 1. Therapy for the patient is surgery to re-seal the leak.
Association Bone Schintigraphy with Prostate Spesific Antigen, Gleason score, and Grade group in Prostate Cancer Patient Reza Rinaldy Harahap; Achmad Hussein Sundawa Kartamihardja; Basuki Hidayat; Hendra Budiawan; Budi Darmawan; Raden Erwin Affandi Soeriadi Koesoemah
Unram Medical Journal Vol 10 No 4 (2021): Jurnal Kedokteran Volume 10 nomor 4 (Desember) 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i4.620

Abstract

Background. Metastasis (especially in bone) in prostate cancer is often difficult to diagnose and poor prognosis. Hence, it is very important to do an early examination in detecting metastasis. Frequent bone scintigraphy indicators are prostate specific antigen (PSA) level and Gleason score (GS). This study aims to analyze how strong correlation of these factors in affecting bone metastasis in prostate cancer. Subject and method. A retrospective cross-sectional analysis study was performed using medical records of the prostate cancer patients who underwent Tc-99m MDP bone scintigraphy at Hasan Sadikin General Hospital during January 2012 until December 2016. PSA level, GS and Gleason grade (GG) data were analyzed by bivariate and multivariate analysis. Result. From 189 medical records, only 110 medical records were eligible to be analyzed. Bivariate analysis demonstrated statistically significant correlation for PSA level (p <0.001) and GS (p 0.05 and p 0.036) with bone metastasis in prostate cancer. Multivariate analysis showed that PSA remains the strongest factor associated with bone metastasis in prostate cancer (p 0.001). Conclusion. From bivariate analysis, serum PSA level have statistically significant correlation with bone metastasis in newly diagnosed prostate cancer patient. In the GS dan GG classification, the higher-grade of GS or GG the higher bone metastasis in prostate cancer patient. Thus, the above results may be helpful in identifying prostate cancer patients who have a high risk for bone metastasis.
Co-Authors Basuki Hidayat Budi Darmawan David Siahaan Hendra Budiawan Kharisma Perdani Kusumahstuti Raden Erwin Affandi Soeriadi Koesoemah Reza Rinaldy Harahap Rian Hidayatullah