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All Journal Journal of Medical Physics and Biophysics Jurnal Fisika FLUX PROSIDING SEMINAR NASIONAL FISIKA (E-JOURNAL)
Deni Hardiansyah
Universitas Indonesia
Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Materials Science & Nanotechnology Medicine & Pharmacology Physics Other

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Review singkat dosimetri internal di kedokteran nuklir menggunakan Physiologically-based Pharmacokinetic (PBPK) model dan topik penelitian paper JMPB volume 7, No. 1 (2020) Deni Hardiansyah
Journal of Medical Physics and Biophysics Vol 7, No 1 (2020)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Seleksi Model pada Peptide-receptor Radionuclide Therapy dengan 177Lu-DOTATATE untuk Dosimetri Ginjal Rahmatul Hanifah; Nur Atikah; M Zaidi Anwari; M Dlorifun Naqiyyun; Ade Riana; Deni Hardiansyah
Jurnal Fisika Flux: Jurnal Ilmiah Fisika FMIPA Universitas Lambung Mangkurat Vol 19, No 2 (2022): Jurnal Fisika Flux: Jurnal Ilmiah Fisika FMIPA Universitas Lambung Mangkurat
Publisher : Lambung Mangkurat University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.548 KB) | DOI: 10.20527/flux.v19i2.12153

Abstract

Seleksi model merupakan aspek penting dari analisis data farmakokinetik. Seleksi model dilakukan untuk memperoleh fungsi terbaik yang selanjutnya digunakan dalam perhitungan nilai TIACs pada dosimetri individu. Data yang digunakan pada penelitian ini berupa data biodistribusi radiofarmaka 177Lu-DOTATATE pada organ ginjal dari 8 pasien PRRT. Setiap data pasien difitting dengan menggunakan beberapa fungsi. Pada setiap fungsi yang diterapkan, dilakukan analisa goodness of fit. Pada setiap fungsi yang memenuhi kriteria goodness of fit dilakukan perhitungan nilai AICc dan nilai pembobotan AICc. Fungsi dengan nilai pembobotan AICc terbesar dipilih menjadi fungsi terbaik. Berdasarkan proses seleksi model yang dilakukan, fungsi f2a,1ex  diperoleh sebagai fungsi terbaik untuk pasien 1,3,4,5,6, dan 7. Sementara itu, fungsi f2b,1ex  menjadi model terbaik untuk pasien 2 dan fungsi f1a,1ex untuk pasien 8.
EVALUATING RENAL TIME-INTEGRATED ACTIVITY COEFFICIENT IN [177Lu]Lu-DOTA-TATE THERAPY: SIMULTANEOUS VS. SEPARATE KIDNEY MODELING USING NON-LINEAR MIXED-EFFECTS MODELING Indra Budiansah; Assyifa Rahman Hakim; Fira Dwi Ananda; Supriyanto Ardjo Pawiro; Deni Hardiansyah
Joint Prosiding IPS dan Seminar Nasional Fisika Vol. 14 No. 1 (2026): Joint Prosiding IPS dan Seminar Nasional Fisika
Publisher : Program Studi Pendidikan Fisika dan Program Studi Fisika Universitas Negeri Jakarta, LPPM Universitas Negeri Jakarta, HFI Jakarta, HFI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/03.1401.FA01

Abstract

This study aimed to compare renal time-integrated activity coefficients (TIACs) in [177Lu]Lu-DOTA- TATE therapy using non-linear mixed-effects modeling (NLMEM), by evaluating the effect of the fitting setting method of left and right kidney biokinetic data to TIAC calculation. Renal biokinetic data of [177Lu]Lu-DOTA-TATE were collected from ten patients with neuroendocrine tumors from literature (PMID:33443063). SPECT/CT imaging was performed between days 1 and 7 after-injection. The bi-exponential function parameters were fitted to biokinetic data using NLMEM performed using NONMEM software, with two fitting approaches: simultaneous fitting of both kidneys and separate fitting of the left and right kidneys. TIACs from the simultaneous fitting were defined as simultaneous TIACs (siTIACs), and those from separate fitting as separated TIACs (seTIACs). The differences between siTIACs and seTIACs were assessed using relative deviations (RDs), with seTIACs considered equivalent to siTIACs if RD was below 5%. The bi-exponential function successfully describes the renal biokinetic data. seTIACs showed good agreement with the siTIACs, with median[min, max] RD of -1.6[-4.5, 0.8]%. Simultaneous fitting of left and right kidneys biokinetic data using the NLMEM approaches produced similar TIACs to those obtained from separate fittings. Therefore, TIACs from simultaneous and separate fittings of renal biokinetic data are comparable and clinically applicable.
THE EFFECTS OF INTRA-INDIVIDUAL VARIABILITY SETTING ON THE ACCURACY OF TIME-INTEGRATED ACTIVITY CALCULATIONS USING NONLINEAR MIXED-EFFECTS MODELING Fira Dwi Ananda; Assyifa Rahman Hakim; Rien Ritawidya; Deni Hardiansyah
Joint Prosiding IPS dan Seminar Nasional Fisika Vol. 14 No. 1 (2026): Joint Prosiding IPS dan Seminar Nasional Fisika
Publisher : Program Studi Pendidikan Fisika dan Program Studi Fisika Universitas Negeri Jakarta, LPPM Universitas Negeri Jakarta, HFI Jakarta, HFI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/03.1401.FA04

Abstract

Estimasi yang akurat terhadap time-integrated activity (TIA) penting untuk perencanaan pengobatan pada peptide receptor radionuclide therapy (PRRT). Dalam konteks pemodelan farmakokinetik, intra-individual variability (IAV) — yang berkaitan dengan ketidakpastian pengukuran — dapat memengaruhi estimasi nilai TIA. Penelitian ini bertujuan untuk meneliti dampak variasi pengaturan IAV terhadap perhitungan TIA. Data biokinetik ginjal (PMID: 33443063) dari 10 pasien tumor neuroendokrin setelah pemberian [¹⁷⁷Lu]Lu-DOTATATE dianalisis menggunakan SPECT/CT. Estimasi TIA dilakukan menggunakan Nonlinear Mixed-Effects Modeling (NLMEM) dengan error model proporsional. Metode 1: TIA referensi (rTIA) dihitung dengan mengestimasi inter-individual variability (IIV) and IAV. Metode 2: Nilai IAV kemudian ditetapkan menjadi setengah (hTIA) dan dua kali lipat (tTIA) dari nilai yang diperoleh pada Metode 1. Pengaruh perubahan IAV terhadap akurasi TIA dievaluasi dengan membandingkan hTIA dan tTIA terhadap rTIA menggunakan relative deviation (RD), root-mean-square error (RMSE), dan mean absolute percentage error (MAPE). Hasil menunjukkan bahwa penetapan IAV menjadi setengah dari nilai referensi menghasilkan RMSE sebesar 5% dan MAPE sebesar 3%. Sementara itu, perubahan dua kali nilai IAV menghasilkan RMSE sebesar 7% dan MAPE sebesar 6%. Secara keseluruhan, perubahan pengaturan IAV memberikan dampak yang sangat kecil, karena perhitungan TIA tetap stabil dan tidak sensitif terhadap variasi IAV, baik ketika nilainya dikurangi setengah maupun digandakan dalam data biokinetik populasi ini.
EFFECT OF PATIENT’S GENDER ON THE CALCULATION OF TIME-INTEGRATED ACTIVITY COEFFICIENT IN RADIONUCLIDE THERAPY: STUDY WITH NON-LINEAR MIXED-EFFECTS MODEL Assyifa Rahman Hakim; Fira Dwi Ananda; Indra Budiansah; Rien Ritawidya; Deni Hardiansyah
Joint Prosiding IPS dan Seminar Nasional Fisika Vol. 14 No. 1 (2026): Joint Prosiding IPS dan Seminar Nasional Fisika
Publisher : Program Studi Pendidikan Fisika dan Program Studi Fisika Universitas Negeri Jakarta, LPPM Universitas Negeri Jakarta, HFI Jakarta, HFI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/03.1401.FA03

Abstract

Purpose: This study investigates the influence of patient gender on the calculation of the Time-Integrated Activity Coefficient (TIAC) in radionuclide therapy. Methods: Kidney biokinetic data (PMID: 33443063) from 10 patients (6 males and 4 females) treated with [¹⁷⁷Lu]Lu-DOTATATE were analysed. A bi-exponential function was used to model both uptake and clearance phases. The reference TIAC (rTIAC) was obtained by fitting the bi-exponential parameters to the complete dataset using a Non-Linear Mixed-Effects Model (NLMEM). To assess the impact of gender, separate NLMEM fits were performed for male and female subgroups to generate estimated TIACs (eTIACs). rTIAC and eTIAC values were compared using the Relative Deviation (RD) and the Root-Mean-Square Error (RMSE). Gender was considered influential if RD or RMSE exceeded 27%. Results: For male patients, the RD was −4.1% ± 7.2% and the RMSE was 8.3%. For female patients, the RD was 5.2% ± 7.8% and the RMSE was 9.4%. Conclusions: Based on the analysed [¹⁷⁷Lu]Lu-DOTATATE biokinetic data, gender does not appear to be a major determinant in TIAC calculation. The deviations between rTIAC and eTIAC remain within an acceptable range for both male and female patients.
Co-Authors Ade Riana Assyifa Rahman Hakim Fira Dwi Ananda Indra Budiansah M Dlorifun Naqiyyun M Zaidi Anwari Nur Atikah Rahmatul Hanifah Rien Ritawidya Supriyanto Ardjo Pawiro