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All Journal B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah
Sri Oktawati
Lecture of Periodontology Department, Faculty Of Dentistry, Hasanuddin University, Indonesia
Dentistry

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PROSPEK MASA DEPAN BAHAN MEMBRAN UNTUK TERAPI REGENERATIF PERIODONTAL: TINJAUAN PUSTAKA Dian Eka Satya; Sri Oktawati
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 8, Nomor 2, September 2021 (Special Edition)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v8i2.864

Abstract

Introduction: Periodontal regenerative therapy goals are to prevent and repair the soft and hard tissue that has been damaged by the infection. The membrane has been used as a material of soft tissue periodontal regenerative therapy. Resorbable and non-resorbable membranes were used as physical barriers to avoiding the growth of connective and epithelial tissue into the defect area. This review will be discussed about the new development of membrane materials for Guided Tissue Regeneration (GTR) which is used in regenerative periodontal therapy along with the advantages of each biomaterial. Review: The barrier membranes used for GTR can be divided into three generations. The first-generation membrane has many structural, mechanical, and biofunctional limitations. The second and third generation of membrane materials is still being developed. The third generation is claimed to function not only as a barrier but also as an antimicrobial agent. It also enhances tissue adhesion and releases the growth factors which are needed for periodontal regeneration. The development of materials used in GTR therapy has been upgraded from only as a barrier to the perspective from being only a barrier to a delivery agent such as antibiotics, growth factors, adhesion factors in the third generation. Conclusion: The GTR procedure has long been used in periodontal regenerative therapy. The latest development for GTR materials not only works as a barrier but also has both bioactive and multilayered nanofibrous membranes that are potential for use in periodontal tissue engineering.
POTENSI TERKINI PERIODONTAL LIGAMEN STEM CELL SEBAGAI TERAPI REGENERATIF PERIODONSIUM: TINJAUAN PUSTAKA Gustivanny Dwipa A; Sri Oktawati
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 8, Nomor 2, September 2021 (Special Edition)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v8i2.887

Abstract

Introduction: Regenerative therapies for periodontium aims to regenerate damaged periodontal tissue. Stem cell-based regenerative therapy may represent an effective therapeutic tool for periodontal regeneration. Periodontal ligament stem cells (PDLSCs) is a type of somatic stem cell that shows the potential to differentiate into several cell types and perform strong self-renewal. Therefore, PDLSCs are considered as a highly promising stem cell population for regenerative therapy in periodontium and need further knowledge regarding to the potential of using PDLSCs as a regenerative periodontium therapy. Literature Review: The periodontal ligament is a marker for stem cell, which is STRO-1. The STRO-1 marker is a colony-forming osteogenic precursor that can be isolated from bone marrow. The STRO-1 marker has the potential to be a phenotype of adipocytes, chondrocytes, and osteocytes. Markers of expression of STRO-1 from the surface of the periodontal ligament show that periodontal ligament cells have osteogenic precursors that can differentiate into osteoblasts. The potential multilineage differentiation of PDLSC including the adipogenic, chondrogenic, and osteogenic potential of PDLSC makes a promising cell source for cell-based regenerative periodontal therapy. Conclusion: The ability of PDLSCs in self renewal, multipotency, and stem cell immunomodulators, provides satisfactory results in the treatment of periodontal defects.
TERAPI GEN PADA PERAWATAN PERIODONTITIS DAN PERI-IMPLANTITIS : A REVIEW DAN IMPLIKASI MASA DEPAN Muhammad Yudin; Sri Oktawati
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 8, Nomor 2, September 2021 (Special Edition)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v8i2.865

Abstract

Introduction: Periodontal disease is a chronic inflammatory condition that affects supporting tissue around the teeth which results in periodontal tissue damage. If left untreated, periodontal disease can cause tooth loss. When this condition occurs around dental implants, the disease is called peri-implantitis. Along with the development of science and technology, various treatments for periodontitis and peri-implantitis have also been found. One of them is gene therapy. Gene therapy is a treatment that is offered and is proven to provide maximum results. Therefore, in this review, we present gene therapy in the application of periodontal tissue and peri-implant regeneration. The purpose of this article is to review the literature on the current of gene therapy in treatment of periodontitis dan peri-implantitis. Review: Periodontitis and peri-implantitis treatment with gene therapy is based on treatment by transferring genetic material to introduce, suppress, or manipulate certain genes that direct a person to have his own cells to produce therapeutic agents. Gen therapy can achieve greater bioavability of growth factors in periodontal wound so that they have greater regenerative potential, both in-vivo and ex-vivo with viral and non-viral vectors. Conclusion: Within the limitation of this review, it was shown that gene therapy could be an alternative in overcoming the weakness of various growth factors and showed promising results.
Co-Authors Dian Eka Satya Gustivanny Dwipa A Muhammad Yudin