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Farah Fatma Wati
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Health Professions Medicine & Pharmacology Public Health

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Tumor Angiogenesis Farah Fatma Wati; Whendy Wijaksono
Jurnal Respirasi Vol. 4 No. 3 (2018): September 2018
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (773.892 KB) | DOI: 10.20473/jr.v4-I.3.2018.102-109

Abstract

Tumor angiogenesis, a process in which blood vessels penetrate and grow in a tumor environment, is needed for oxygen and nutrient supply and plays an important role in the survival of solid neoplasms. Angiogenesis does not only have a role in tumor development and metastasis, but also acts as marker of cancer itself (hallmark of cancer). Several mechanisms of angiogenesis include vasculogenesis, sprouting angiogenesis, intussusception microgrowth, and vasculogenic mimicry. Knowing these different mechanisms will be helpful in choosing the best agents or drugs for cancer therapy. The first anti-angiogenic drug used was bevacizumab, a monoclonal antibody, directed against VEGF. Bevacizumab has significant clinical benefits in patients with advanced NSCLC.
Co-Authors Whendy Wijaksono