Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Jurnal Medika Hutama Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Diah Balqis Ikfi Hidayati
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
SINGLE NUCLEOTIDE POLYMORPHISM (SNP) IDENTIFICATION of CIRCUMSPOROZOITE PROTEIN GENE in Plasmodium falciparum FROM MALARIA PATIENTS IN WORKING AREA of PRIMARY HEALTH CARE HANURA, PESAWARAN, LAMPUNG Diah Balqis Ikfi Hidayati
Jurnal Medika Hutama Vol. 3 No. 04 Juli (2022): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Malaria is an infectius disease caused by Plasmodium sp. The treatment for malaria with Artemisinin-based Combination Therapy (ACT) can cause resistance, so a new effort is needed to reduce the morbidity of malaria. A better prevention method for preventing malaria is to use vaccine. The RTS,S/AS01 vaccine is the first generation malaria vaccine that has been applied in Ghana, Kenya and Malawi since early 2018. The vaccine consists of circumsporozoite protein (CSP) antigen. This study aims to detect the presence of SNPs in CSP that are useful as a database of genetic variation for vaccine development in Indonesia.This type of research is a descriptive research with survey design. The sample of research was obtained from Biological Saved Materials (BSM) as many as 53 samples. The examination was performed using by PCR method and followed by a sequencing process to detect SNP. The results showed that only 16 samples had high DNA concentration and the sequencing results showed there is no difference in nucleotide base sequences compared to references on Pf3D7 isolates from Gene Bank. So the conclusion is there is no SNP on the CSP gene in Plasmodium falciparum from malaria patients in the working area of Primary Health Care Hanura, Pesawaran, Lampung.
Intoksikasi Organofosfat dengan Krisis Kolinergik Akut, Gejala Peralihan dan Polineuropati Tertunda Diah Balqis Ikfi Hidayati
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 6 No. 2 (2019): Jurnal Kesehatan dan Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Organofosfat adalah jenis pestisida yang banyak digunakan di dunia. Penggunaan organofosfat secara besar-besaran disektor pertanian akan berakibat pada kesehatan petani itu sendiri. Penggunaan organofosfat sering tidak proporsional terutama bila terjadi serangan hama atau setelah hujan. Kondisi ini diperparah dengan ketidakpedulian petani terhadap bahaya pestisida yang dapat meracuni petani, keluarga, dan lingkungannya. Keracunan akibat senyawa ini merupakan masalah kesehatan masyarakat yang sering terjadi di sektor pertanian. Zat neurotoksik yang terkandung dalam organofosfat dapat menyebabkan munculnya sindrom neurologis khas yang berdasarkan onsetnya dibagi menjadi tiga jenis tahapan yang berbeda, yaitu krisis kolinergik akut, gejala peralihan dan polineuropati tertunda. Gejala-gejala tersebut dapatberakibat fatal hingga bisa menyebabkan kematian. Untuk mencegah terjadinya komplikasi perlu dilakukan penanganan yang tepat terhadap kasus keracunan pestisida dengan pemberian terapi farmakologi berupa atropin dan/atau oximes.Kata kunci: gejala peralihan, krisis kolinergik akut, organofosfat, polineuropati tertunda
Co-Authors