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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pengabdian Masyarakat AMMA : Jurnal Pengabdian Masyarakat Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat
Niluh Puspita Dewi
Departments Of Pharmacology And Clinical Pharmacy, STIFA Pelita Mas Palu, Central Sulawesi, 94111, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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FORMULASI DAN UJI EFEKTIVITAS GEL ANTISEPTIK EKSTRAK ETANOL DAUN BELUNTAS TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS Niluh Puspita Dewi
Jurnal Farmasindo Vol 5 No 1 (2021): Juni
Publisher : Program Studi D3 Farmasi Politeknik Indonusa Surakarta

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Abstract

Tanaman Beluntas (Pluchea indica Less) merupakan salah satu tanaman yang berkhasiat obat. Tanaman beluntas memiliki kandungan senyawa flavonoid yang diketahui memiliki aktivitas antibakteri. Tujuan penelitian ini adalah untuk membuat formula gel antiseptik dan untuk mengetahui pengaruh penggunaan variasi konsentrasi ekstrak etanol daun beluntas terhadap stabilitas fisik sediaan gel serta untuk mengetahui konsentrasi ekstrak etanol daun beluntas dalam gel antiseptik yang efektif dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Metode penelitian ini merupakan penelitian eksperimental laboratorium. Ekstrak etanol daun beluntas diperoleh dengan metode maserasi menggunakan pelarut etanol 96% dan diformulasikan menjadi sediaan gel antiseptik dengan tiga variasi konsentrasi ekstrak. Hasil penelitian menunjukkan bahwa ekstrak etanol daun beluntas dapat diformulasikan menjadi sediaan gel antiseptik dengan konsentrasi 2%, 4% da 6%. Konsentrasi ekstrak etanol daun beluntas mempengaruhi pH, viskositas dan aktivitas antibakteri terhadap Staphylococcus aureus, tetapi tidak mempengaruhi stabilitas mutu fisik, organoleptik dan homogenitas gel. Hasil pengukuran daya hambat gel antiseptik diperoleh diameter rata-rata zona bening untuk F1 (2%), F2 (4%) dan FIII (6%) berurut-turut adalah 9,67 mm, 11,5 mm, dan 16 mm. Berdasarkan klasifikasi kekuatan antibakteri, maka kemampuan penghambatan bakteri uji oleh sediaan gel antiseptik konsentrasi 2% dan 4% dikategorikan sedang, serta 6% dikategorikan kuat yang merupakan gel antiseptik paling efektif menghambat aktivitas bakteri Staphylococcus aureus.
Penyuluhan Stunting: Upaya Pencegahan BALITA Stunting Niluh Puspita Dewi; Syafika Alaydrus; Indah Kurnia Utami; Sri Wahyuni Khalik; Magfirah Magfirah; Nur Azizah
Jurnal Mandala Pengabdian Masyarakat Vol. 4 No. 2 (2023): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v4i2.327

Abstract

Penyuluhan merupakan suatu cara yang dilakukan oleh seseorang untuk memperoleh informasi kesehatan atau derajat kesehatan secara maksimal.  Stunting merupakan penggambaran dari status gizi kurang yang bersifat kronik pada masa pertumbuhan dan perkembangan sejak awal kehidupan. Banyak faktor yang dapat menyebabkan terjadinya stunting pada balita seperti karakteristik balita maupun faktor sosial ekonomi. Stunting menjadi permasalahan karena berhubungan dengan meningkatnya risiko terjadinya kesakitan dan kematian, perkembangan otak suboptimal sehingga perkembangan motorik terlambat dan terhambatnya pertumbuhan mental. Penyuluhan ini bertujuan membantu meningkatkan pengetahuan masyarakat terutama ibu-ibu tentang pencegahan stunting pada balita dan merupakan salah satu bentuk Tri Dharma Perguruan Tinggi.  Penyuluhan diberikan dengan metode ceramah interaktif melalui pembagian leaflet, dan bakti sosial. Efektifitas penyuluhan diuji dengan pemberian kuisioner kepuasan mitra terhadap kegiatan yang dilaksanakan. Hasil pengamatan kegiatan menunjukkan bahwa Mitra merasa puas dengan kegiatan penyuluhan yang dilakukan.
Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats Niluh Puspita Dewi; Syafika Alaydrus; Nadila Nadila; Magfirah Magfirah; Joni Tandi; Viani Anggi; Nani Astria
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27489

Abstract

Coconut (Cocos nucifera) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because The composition of VCO consists of medium-chain fatty acids that can maintain a healthy body and prevent various diseases. The process of making VCO used in This research is an enzymatic method using pineapple weevil as a bromelain enzyme. This study aims to determine the effect of enzymatic administration of VCO and an enzymatic dose of VCO which is effective in reducing urea and creatinine levels in hypercholesterolemic-diabetic male white rats (Rattus norvegicus). This study was an experimental laboratory with a modified pretest and posttest randomized controlled group design using 30 test animals which were divided into 6 treatment groups. Each group consisted of 5 test animals, namely normal control, negative control, and positive control, with doses of 0.2, 0.4, and 0.8 mL/kg BW. The data obtained were analyzed using a One Way Anova and non- parametric statistical test by Kruskal Wallis. test and followed by a further Mann Whitney test to determine differences between treatments. The results showed that enzymatic VCO at a dose of 0.8 mL/kg BW was an effective dose in reducing urea and creatinine levels with an average decrease of 17.40 mg/dL and 0.36 mg/dL. The novelty in this study showed that the enzymatic VCO had an effect on reducing urea and creatinine levels in diabetic hypercholesterolemic male white rats.
Potensi Bunga Telang Sebagai Antioksidan dalam Produk Olahan Seduhan Teh Herbal niluh Puspita Dewi; Maramis
AMMA : Jurnal Pengabdian Masyarakat Vol. 1 No. 06 (2022): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

The telang flower plant is known as the Latin Buterfly pea, while the scientific language is Clitoria ternatea. Telang (Clitoria ternatea) is a type of wild plant that has health benefits for the human body. One of the processed pea flower that is useful is as a health drink. The potential of the telang flower has been proven through several studies, namely the bioactive components found in the telang flower, including flavonol glycosides, anthocyanins, flavones, flavonols, phenolic acids, terpenoid and alkaloid compounds, as well as cyclic peptide compounds or cyclotides. This community service activity aims to provide education to residents of Sopu Village, Nokilalaki District, Sigi Regency about the benefits of telang flower and can use it into processed products, such as fresh and dried herbal tea of ​​telang flower. The implementation method of this community service activity is the lecture, discussion and question and answer method. The results of this counseling, it is hoped that the residents of Sopu Village, Nokilalaki District, Sigi Regency have an independent business in making products made from telang flower so that they can improve the economy of the residents of Sopu Village.
SWAMEDIKASI PENGGUNAAN OBAT ALERGI SEBAGAI UPAYA MENINGKATKAN PENGETAHUAN MASYARAKAT DI DESA SEJAHTERA KECAMATAN PALOLO: SWAMEDIKASI PENGGUNAAN OBAT ALERGI SEBAGAI UPAYA MENINGKATKAN PENGETAHUAN MASYARAKAT DI DESA SEJAHTERA KECAMATAN PALOLO indah kurnia utami; Ratna Ika Yususf; niluh puspita dewi; Syafika Alaydrus
AMMA : Jurnal Pengabdian Masyarakat Vol. 1 No. 06 (2022): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Self-medication or what is known as self-medication is one of the actions that are often taken by the community to treat skin disorders. Based on a systematic review, it is known that the prevalence of self-medication in skin diseases ranges from 6-44%. Research in Togo, Africa found that 91.1% of people with skin disorders who seek treatment at health services have self-medicated before going to health services, while research conducted in Jakarta showed 44.64% of people were self-medicating for skin diseases with modern or traditional medicines. Allergies are reactions of the human immune system to certain objects, which should not cause reactions in other people's bodies. The reaction can appear in the form of a runny nose, itchy skin rash, or even shortness of breath. The drugs used by the public in self-medication of skin diseases are oral and topical drugs, including preparations containing corticosteroids, antibiotics and antifungals, a combination of salicylic acid and benzoic acid. Self-medication behavior can be influenced by knowledge, sociodemographic characteristics, family and advertising. Based on research, knowledge is the most significant factor influencing self-medication behavior.
Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Pancreas of Wistar Rats Yunira Wardani; Niluh Puspita Dewi; Syafika Alaydrus; Meike Rachmawati
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.8069

Abstract

Medicinal plants are considered a rich source of bioactive metabolites and have the potential for the discovery and development of new drugs, one of which is the purple leaf plant which is known to treat various diseases. The aim of this research was to determine the effect of administering purple leaf ethanol extract over a certain period of time at doses of 500 mg/kgBB, 2.000 mg/kgBB and 5.000 mg/kgBB on the histopathology of the Wistar rat pancreas. In this study, an experimental method was used with a randomized block design, using 20 male Wistar rats which were divided into 4 research groups, 1 control group which was given Na-CMC. and 3 treatment groups were given purple leaf ethanol extract at a dose of 500 mg/kgBB (P1), dose of 2.000 mg/kgBB (P2) and  dose of 5.000 mg/kgBB (P3). The test preparation was administered orally, for 28 days. The results of subchronic toxicity testing of purple leaf ethanol extract on Wistar rats carried out for 28 days, up to a dose of 5.000 mg/kg BB, showed that at a dose of 2.000 mg/kg BB – 5.000 mg/kg BB it was toxic to the histopathology of the Wistar rats pancreas, which was characterized by the presence of cell degeneration, increased organ index and the presence of symptoms of toxicity
Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Lymph of Wistar Rats and Antioxidant Activity Darmayanti; Niluh Puspita Dewi; Mariyani; Joni Tandi; Meike Rachmawati; Yuliet Susanto
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.8070

Abstract

This study aims to determine the toxic effects of purple leaf ethanol extract on lymph organs at doses of 500; 2.000; and 5.000 mg/kgBB administered for 28 days and and to determine the antioxidant activity of purple leaf Graptophyllum pictum (L.) This study is an experimental study with a random group design, using 20 test animals divided into 4 groups consisting of two treatment groups, namely in the normal control group given Na-CMC 0.5% and the experimental group given PLEE (k1: dose 500 mg/kgBB, k2: dose 2.000 mg/kgBB and k3: dose 5.000 mg/kgBB hematoxylin-eosin staining (HE) using a computer-connected Motic BA210 microscope with 40X magnification in 5 fields of view and antioxidant test using DPPH method with UV-Vis Spectrophotometer at 516 nm wavelength with concentration 20, 40, 60, 80, and 100 ppm. The results showed that leaf ethanol extract was toxic at a dose of 2.000 mg/kgBB – 5.000 mg/kgBB against the diameter of lymphatic organ pulp, organ index and organ weight, there were symptoms of toxicity and purple leaf ethanol extract had strong antioxidant activity with 66.26 μg/mL.
UJI TOKSISITAS SUB KRONIS EKSTRAK DAUN UNGU TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH JANTAN I Made Dipayana; Niluh Puspita Dewi; Magfira; Joni Tandi; Wayan Wirawan; Meike Rachmawati; Nur Azizah
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8312

Abstract

Traditional herbal medicine has become increasingly popular as an alternative to conventional medical treatments. Although the plant offers numerous health benefits, caution should be exercised regarding its long-term use. Long-term use of traditional herbal remedies can have detrimental effects on the kidneys. This study was designed to assess the histological changes in the kidneys of male rats following 28 days of purple sage leaf extract administration and to identify potential harmful effects. The study utilized 20 male Wistar rats and utilized a randomized group design for the experimental methodology. Rats were categorized into four distinct groups, consisting of one control group and three treatment groups. The control group received solely sodium chloride, whereas the treatment group 1 (P1) received 500 mg/kg BB of purple sage ethanol extract. Treatment group 2 received up to 2000 mg/kg BB of purple sage ethanol extract, while treatment group 3 received up to 5000 mg/kg BB. The oral examination was conducted for a duration of 28 days. The treatment groups showed an increase in weight and organ index of the right kidney. The findings suggest a potential for toxicity resulting from the administration of purple sage leaf extract over a duration of 28 days.
Anti-Cancer Activity Of The Combination Of Marine Mineral Consentrates And α Mangostin On Prostate Cancer Line DU 145 And HEK 293 By WST-8 Method Giska Putri Agustina; Syafika Alaydrus; Niluh Puspita Dewi
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8518

Abstract

Marine mineral concentrates have good activity against normal cells, but are less effective against cancer cells. This research was carried out by combining concentrations of sea minerals with natural ingredients that have anti-cancer potential, one of which is α-mangostin. This study aims to determine the IC50 of the combination of α-mangostin, marine mineral concentrate, the combination of α-mangostin & marine mineral concentrate when compared cisplatin and evaluate the activity of α-mangostin, KML and the combination of α-mangostin and KML compared with ciplatin against the DU 145 cancer cell line and HEK 293. The method used is cytotoxicity testing using the WST-8 method. The results of the test materials were α-Mangostin 16.89 ppm, the combination of α-Mangostin-KML with a concentration of 12.5 ppm, namely 1,732 ppm, the combination of α-Mangostin-KML with a concentration of 25 ppm, namely 4,930 ppm, the combination of α-Mangostin-KML with concentration of 50 ppm 5,194 ppm, and cisplatin 4,649 ppm. The results of data analysis show significant differences for all samples. Conclusion α-Mangostin helps KML increase the cytotoxic effect on DU 145 cancer cells and sea mineral concentrate helps reduce the cytotoxic effect of α-Mangostin on normal HEK-293 cells.
Determination of specific and non-specific standardization parameters for ethanol extract of purple leaves (Graptophyllum pictum (L) Griff ) Rivani Tampang; Syafika Alaydrus; Niluh Puspita Dewi; Joni Tandi
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8812

Abstract

this study aims to determine the standardization of specific parameters (organoleptic and chemical content) and non-specific parameters (ash content, water content, drying loss, heavy metal contamination, Yeast Mold Number (AKK), microbial contamination / Total Plate Count (ALT)). The results showed that the specific parameters of the organoleptic properties of 96% ethanol extract of purple leaves (Grapthophyllum pictum (L) Griff) were black, shaped like a paste, a distinctive purple leaf odor and a bitter taste. The results of phytochemical screening of 96% purple leaf ethanol extract contained alkaloids, flavonoids, and tannins. However, the saponin test was negative for saponins. Non-specific parameters of 96% ethanol extract of cherry leaves were water content of 5.96%, total ash content of 16.86%, drying loss of 17.26%, heavy metals As and Cd were not detected, the presence of metals in Pb was 0.12 mg / kg, microbial contamination (Alt) and yeast mold numbers (Akk) were not found colonies. Based on these results, it can be concluded that the standardization test of specific and non-specific parameters, the ethanol extract of purple leaves has met the quality standards of simple drugs.
Co-Authors Athia Kurnia Kasim Ayu Wulandari Darmayanti Dhitania Ivana Harliwong Dian Andini Giska Putri Agustina I Made Dipayana Imelda Synthia Fatu Indah Kurnia Utami Indah Kurnia Utami Irma Irma Joni Tandi, Joni Komang Dewik Magfira Maramis Mariyani Meike Rachmawati Nadila Nadila Nani Astria Nani Astria Polontalo Nur Azizah Putu Intan Ratna Ika Yususf Rivani Tampang Sri Wahyuni Khalik Sririzqi Muthmainnah Syafika Alaydrus Syafika Alaydrus Syafika Alaydrus Viani Anggi Wayan Wirawan Yuliet Yuliet Yunira Wardani