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All Journal Interest : Jurnal Ilmu Kesehatan Cermin Dunia Kedokteran JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Cermin Dunia Kedokteran
Retno Danarti
Departemen/KSM Dermatologi Dan Venereologi Fakultas Kedokteran, Kesehatan Masyarakat Dan Keperawatan Universitas Gadjah Mada/RSUP Dr. SardjitoYogyakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Diagnosis Alopesia Areata Pada Anak: Kasus Serial Haken Tennizar Toena; Retno Danarti
Cermin Dunia Kedokteran Vol 49, No 4 (2022): Infeksi - COVID-19
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i4.1824

Abstract

Alopesia areata (AA) merupakan penyakit autoimun yang ditandai dengan alopesia non-sikatrisial. Kondisi ini merupakan dermatosis yang umum ditemui pada anak. Gambaran klinisnya berupa alopesia non-sikatrisial fokal, perlu dibedakan dari kondisi dapatan serupa lainnya, terutama yang sering terjadi pada anak. Kami melaporkan 5 kasus AA pada anak berusia di bawah 18 tahun. Diagnosis berdasarkan pemeriksaan klinis dan penunjang. Pemahaman karakteristik AA perlu diketahui untuk diagnosis, terutama pada pasien anak.Alopecia areata (AA) is a chronic autoimmune disease characterized by non-scarring alopecia. It is one of the most commonly found dermatosis in pediatric population. The clinical manifestations of focal non-scarring alopecia must be differentiated from other acquired focal non-scarring alopecia, especially those in children. This paper report 5 AA cases in children. Diagnosis was based on clinical and supporting examinations. Understanding the characteristics of AA, particularly in children, is important to make correct diagnosis.
The effectiveness of personal preventive measures against occupational contact dermatitis in healthcare workers: A systematic review Khansa Maria Salsabila; Sri Awalia Febriana; Retna Siwi Padmawati; Retno Danarti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 2, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss2art12

Abstract

Healthcare workers (HCWs) embody the principles of hand hygiene and protective attire to support self- and patient safety, but the materials involved in this process are found to be offending agents. The incidence of occupational contact dermatitis (OCD) among HCWs keeps increasing. This review aimed to evaluate the effectiveness, investigate the outcome and clinical skin condition improvement with the implementation of primary preventive measures (PPM), specifically: barrier cream, emollient, moisturiser, gloves use, and education. All relevant literature about PPM against OCD among HCWs published between 1995 to 2020 was searched. The data search was performed using the PUBMED, Cochrane Library, and ScienceDirect databases. There were 16 studies comprised of 8 randomised controlled trials (RCTs), 7 clinical trials, and one comparative study. The study results showed that using barrier cream, moisturiser or emollient, gloves, and education were effective tools in reducing the number of clinical symptoms in cases of OCD. There was no significant difference in the effect between barrier cream use and moisturiser or emollient. The gloves were advised to be used non-latex gloves or powder-free latex gloves. Education was also observed to improve preventive behaviour among workers. The use of barrier cream, emollient, moisturiser, and gloves is recommended to be educated to ascertain the proper use of preventive measures, increase knowledge and awareness, and promote positive preventive behaviour.
Formulation Of Topical Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) Of Vitamin D3 Adeltrudis Adelsa Danimayostu; Ronny Martien; Endang Lukitaningsih; Retno Danarti
Interest : Jurnal Ilmu Kesehatan INTEREST: Jurnal Ilmu Kesehatan Volume 11 Number 2 Year 2022
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/interest.v0i0.532

Abstract

Background: In the last few decades, there has been a significant increase in customers’ interest in skin care, including anti-aging. One of the skin care substances, vitamin D3, has a positive impact on the skin, such as the keratinocyte differentiation effect to maintain the skin barrier and the hydration effect to keep the skin moist. Vitamin D3 has a high lipophilicity, so it is considered ideal to formulate in the self-nano emulsifying drug delivery system (SNEDDS). The higher solubility of vitamin D3 in the SNEDDS oil component could improve its penetration through the skin. The SNEDDS is a primary dosage form that can be entrapped in semisolid base dosage forms, such as cream, lotion, or gel. SNEDDS vitamin D3 needs to be optimized to obtain the appropriate composition of the components: oil, surfactant, and co-surfactant. Methods: The D-Optimal Mixture method using Design Expert 10 software had been chosen as an optimization tool for SNEDDS vitamin D3. Results: The composition of the optimum formula was obtained as follows: 1.0351 g Miglyol 812 N; 3.0637 g Tween 80 and 0.9011 g PEG 400. The optimum formula has a particle size of 32.62 nm ± 1.80 nm and a polydispersity index of 0.31 ± 0.03. Conclusion: The release test was carried out with the help of a Franz diffusion cell instrument, a cellophane membrane, and phosphate-buffered saline pH 7.4 containing 0.5% Tween 80. The cumulative amount of vitamin D3 released per minute (Flux) was 0.10 µg/min.
Diagnosis Alopesia Areata Pada Anak: Kasus Serial Haken Tennizar Toena; Retno Danarti
Cermin Dunia Kedokteran Vol 49 No 4 (2022): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i4.222

Abstract

Alopesia areata (AA) merupakan penyakit autoimun yang ditandai dengan alopesia non-sikatrisial. Kondisi ini merupakan dermatosis yang umum ditemui pada anak. Gambaran klinisnya berupa alopesia non-sikatrisial fokal, perlu dibedakan dari kondisi dapatan serupa lainnya, terutama yang sering terjadi pada anak. Kami melaporkan 5 kasus AA pada anak berusia di bawah 18 tahun. Diagnosis berdasarkan pemeriksaan klinis dan penunjang. Pemahaman karakteristik AA perlu diketahui untuk diagnosis, terutama pada pasien anak. Alopecia areata (AA) is a chronic autoimmune disease characterized by non-scarring alopecia. It is one of the most commonly found dermatosis in pediatric population. The clinical manifestations of focal non-scarring alopecia must be differentiated from other acquired focal non-scarring alopecia, especially those in children. This paper report 5 AA cases in children. Diagnosis was based on clinical and supporting examinations. Understanding the characteristics of AA, particularly in children, is important to make correct diagnosis.
Diagnosis Alopesia Areata Pada Anak: Kasus Serial Haken Tennizar Toena; Retno Danarti
Cermin Dunia Kedokteran Vol 49 No 4 (2022): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i4.222

Abstract

Alopesia areata (AA) merupakan penyakit autoimun yang ditandai dengan alopesia non-sikatrisial. Kondisi ini merupakan dermatosis yang umum ditemui pada anak. Gambaran klinisnya berupa alopesia non-sikatrisial fokal, perlu dibedakan dari kondisi dapatan serupa lainnya, terutama yang sering terjadi pada anak. Kami melaporkan 5 kasus AA pada anak berusia di bawah 18 tahun. Diagnosis berdasarkan pemeriksaan klinis dan penunjang. Pemahaman karakteristik AA perlu diketahui untuk diagnosis, terutama pada pasien anak. Alopecia areata (AA) is a chronic autoimmune disease characterized by non-scarring alopecia. It is one of the most commonly found dermatosis in pediatric population. The clinical manifestations of focal non-scarring alopecia must be differentiated from other acquired focal non-scarring alopecia, especially those in children. This paper report 5 AA cases in children. Diagnosis was based on clinical and supporting examinations. Understanding the characteristics of AA, particularly in children, is important to make correct diagnosis.
Co-Authors Adeltrudis Adelsa Danimayostu Endang Lukitaningsih Febriana, Sri Awalia Haken Tennizar Toena Haken Tennizar Toena Khansa Maria Salsabila Retna Siwi Padmawati Ronny Martien