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All Journal Jurnal Respirologi Indonesia Journal of Tropical Pharmacy and Chemistry
Amelia Lorensia
Department of Clinical-Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Cost-Effectiveness Analysis of Budesonide/Formoterol and Fluticasone/Salmeterol for Stable Chronic Obstructive Lung Disease Amelia Lorensia; Monica Dyah Puspitasari; Soedarsono Soedarsono; Rivan Virlando Suryadinata
Jurnal Respirologi Indonesia Vol 42, No 4 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i4.378

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is one of the four largest types of non-communicable diseases in the world, requiring long-term and routine treatment. Treatment with the inhalation route is in the form of a dry-powder inhaler (DPI) which is easy to use and carry. Combination of corticosteroid and long-acting beta-2 agonist (LABA) in the form of DPI available in Indonesia are budesonide/formoterol and salmeterol/fluticasone. The purpose was to identify therapy was more cost-effective between budesonide/formoterol than fluticasone/salmeterol in clinical symptoms using COPD assessment test (CAT) value and lung function in FEV1/FVC (Forced Expiratory Volume in First Seconds/Forced Vital Capacity) ratio.Methods: This research study was pre-post design with cost-effectiveness analysis, in outpatient COPD patients in a hospital in Gresik Regency, from October 2019 to January 2020. There were two outcomes of respondents in this study, namely lung function seen from the value of FEV1, and clinical symptoms seen from the value of CAT. The study used hospital perspective.Results: There were 38 respondents involved. Fluticasone/salmeterol therapy was more effective than the budesonide/formoterol group in improving FEV1/FVC ratio, while budesonide/formoterol was more effective than the fluticasone/salmeterol group in improving clinical symptoms by CAT assessment. The average cost effectiveness ratio (ACER) value of lung function between the fluticasone/salmeterol group (IDR.176.465/Liter) was lower than that of budesonide/formoterol (IDR.296.832/Liter). The ACER clinical symptoms value between the fluticasone/salmeterol group (IDR.16,283/score) was smaller than that of budesonide/formoterol (IDR.17,340/score). Conclusion: Fluticasone/salmeterol was more cost-effective than budesonide/formoterol in improving lung function. Meanwhile, for clinical symptoms, fluticasone/salmeterol was trade-off with budesonide/formoterol.
Relationship of Knowledge on Respiratory Disorders with Lung Function in Masons in East Surabaya Amelia Lorensia; Rivan Virlando Suryadinata; Wilma Adib Gardiawan
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.342

Abstract

Masons are regularly exposed to air pollution in the workplace The pollution exposure received by them is a risk factor for respiratory problems. Most of the masons had insufficient knowledge that is very important for the management of a person's illness. The purpose of this study was to determine relationship of knowledge on respiratory disorders with lung function in masons in east surabaya. This research was an observational study with a cross-sectional design with a purposive method.The research was conducted from April to July 2019 in the East Surabaya area. The variables that will be observed in this study are the level of knowledge of risk factors, symptoms, and treatment and therapy regarding respiratory disorders. In this study, there were 158 respondents consisting of 79 groups with impaired lung function and 79 groups without lung function disorders. Most of the level of knowledge of both groups was good in risk factors and treatment of respiratory disease, but instead on the symptoms regarding respiratory disease. The research showed that there was a relationship between the level of knowledge about risk factors for respiratory disease (p(0.223)<0.05) and lung function, but there was no difference in knowledge about symptoms (p(0.745)<0.05) and treatment (p(0.741)<0.05) respiratory disease with pulmonary function. Therefore, it was necessary to plan further educational programs in increasing masons' knowledge of respiratory symptoms so that they could catch respiratory diseases earlier.
Co-Authors Monica Dyah Puspitasari Rivan Virlando Suryadinata Rivan Virlando Suryadinata S. Soedarsono Wilma Adib Gardiawan