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Tayseer Zein
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Medicine & Pharmacology

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Analysis of fatty acids in Ghee and olive oil and their probable causal effect in lipoid pneumonia Mirghani, Zein; Zein, Tayseer; Annoble, Samuel; Winter, John; Mostafa, Randa
Medical Journal of Indonesia Vol 19, No 4 (2010): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.763 KB) | DOI: 10.13181/mji.v19i4.410

Abstract

Aim: To analyze and identify the fatty acids found in homemade ghee and in olive oil and compare those to fatty acids found in bronchoalevolar lavage of children with lipoid pneumonia.Methods: The fatty acids found in homemade fat ”Ghee” and olive oil were analyzed by gas chromatography. Methyl ester derivatives suitable for GC analysis were prepared directly from olive oil or from Ghee using anhydrous methanolic-HCl. Bronchoscopy and bronchoalevolar lavage was performed in eight children aged between 2 and 4 years, all with history of using homemade ghee and/or olive oil in the recumbent position.Results: The analysis of fatty acids in Ghee and olive oil show similar gas chromatographic pattern as those of bronchoalevolar lavage.Conclusion: The three fatty acids responsible for the deleterious effects of lipoid pneumonia were identified. Lipoid pneumonia should be one of the differentials diagnosis in children  presenting with respiratory distress. (Med J Indones 2010; 19:252-7)Keywords: Bronchoalevolar lavage, gas chromatography, Ghee, methyl esters, lipoid pneumonia
Co-Authors John Winter Randa Mostafa Samuel Annoble Zein Mirghani