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Izza Aliya
Oncology Gynecology Division, Obstetrics and Gynecology Department, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Telomerase Inhibitor: Promising Target Therapy for Cancer Diana Kusuma; Izza Aliya; Andre Putra; Mediana Sutopo
Cermin Dunia Kedokteran Vol 45, No 4 (2018): Cedera Kepala
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i4.670

Abstract

The key to selectively targeting cancer cells is to exploit some basic differences with their normal precursors. One such difference is the activity of the enzyme telomerase. Some studies targeted telomerase and telomeres in order to block limitless replicative potential of cancer cells, providing a fascinating strategy for a broad-spectrum cancer therapy. Telomerase based therapies could be well tolerated and perhaps with minimal side effect on telomerase-competent stem cells.Kunci pengobatan selektif sel kanker adalah dengan memanfaatkan beberapa perbedaan mendasar antara prekursor sel kanker dengan sel normal tubuh. Salah satu perbedaannya adalah aktivitas enzim telomerase. Beberapa penelitian sudah menargetkan telomerase dan telomer sebagai target terapeutik untuk memblokir potensi replikasi sel kanker yang tak terbatas, sebagai strategi terapi kanker spektrum luas. Terapi berbasis telomerase ini dapat ditoleransi dengan baik dan memiliki efek samping minimal pada telomerase sel normal tubuh lainnya.
Co-Authors Andre Putra Diana Kusuma Mediana Sutopo