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Nugroho Nitiyoso
Departemen Medical PT. Kalbe Farma Tbk. Jakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Peran Janus Kinase inhibitor pada Penyakit Autoimun Nugroho Nitiyoso
Cermin Dunia Kedokteran Vol 49 No 12 (2022): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i12.327

Abstract

Modalitas pengobatan utama penyakit autoimun adalah obat immunosupresif, misalnya methotrexate, TNFi-biologics, non-TNFi-biologics, dan yang paling baru adalah Janus Kinase inhibitor. Mekanisme kerja Janus Kinase inhibitor adalah dengan cara menghambat kerja enzim Janus Kinase pada proses signaling respons imun. Dalam artikel ini akan dibahas beberapa obat Janus Kinase inhibitor seperti: tofacitinib, baricitinib, upadacitinib, dan filgotinib, serta peran obat-obat ini pada pengobatan penyakit autoimun. The main treatment modality for autoimmune disease is immunosuppressive drugs, eg methotrexate, TNFi-biologics, non-TNFi-biologics, and most recently Janus Kinase inhibitors. The mechanism of action of Janus Kinase inhibitor drugs is by inhibiting the action of the Janus-Kinase enzyme in the signaling process of the immune response. This article will discuss several Janus Kinase inhibitor drugs such as: tofacitinib, baricitinib, upadacitinib, and filgotinib, as well as their role in the treatment of autoimmune diseases.
Pilihan Pengobatan Artritis Rematoid Nugroho Nitiyoso
Cermin Dunia Kedokteran Vol 47 No 4 (2020): Interna
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i4.362

Abstract

Artritis rematoid (rheumatoid arthritis, RA) adalah salah satu penyakit autoimun yang prevalensinya tinggi, di Indonesia, yaitu diperkirakan 0,3%. Pengobatan RA dapat menjadi tantangan mengingat derajat gejala bisa sangat berbeda antar pasien, serta respons terhadap pengobatan juga tidak sama. Selain itu, juga berisiko efek samping. Artikel ini akan membahas pilihan-pilihan pengobatan RA. Rheumatoid arthritis is an autoimmune disease with a high prevalence, the estimated prevalence in Indonesia is 0.3%. Treatment of rheumatoid arthritis can be challenging due to the variability of symptoms and severity, difference of response to treatment; in addition to side effects risks. This literature review will discuss some rheumatoid arthritis treatment options.
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