Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Cermin Dunia Kedokteran Cermin Dunia Kedokteran
Jason Phowira
Fakultas Kedokteran Universitas Indonesia, Jakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Integrasi Misoprostol dalam Daftar Obat Esensial Nasional sebagai Alternatif Penanganan Perdarahan Pasca-Persalinan di Wilayah Pedesaan di Indonesia Edward Christopher Yo; Muhammad Alifian Remifta Putra; Jason Phowira
Cermin Dunia Kedokteran Vol 47, No 10 (2020): Optalmologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i10.1091

Abstract

Di Indonesia, angka kematian ibu akibat perdarahan pasca-persalinan (PPP) masih tinggi, terutama di wilayah pedesaan dengan akses terhadap oksitosin sebagai obat lini utama masih sangat terbatas. Misoprostol berpotensi menjadi alternatif oksitosin untuk penanganan PPP di wilayah pedesaan. Telaah literatur manfaat misoprostol menggunakan search engine Google Scholar, PubMed, dan NCBI, dengan kata kunci “misoprostol”, “perdarahan pasca-persalinan”, “wilayah dengan sumber daya rendah”, farmakokinetika”, “farmakodinamika”, dan “Indonesia”. Ditinjau dari aspek Cmax, Tmax, dan AUC, jalur sublingual diduga paling efektif. Penelitian lebih lanjut diperlukan untuk memastikan rute pemberian serta dosis misoprostol yang paling efektif untuk penanganan kasus PPP. Namun, misoprostol belum terdaftar di Daftar Obat Esensial Nasional (DOEN). Ditetapkannya misoprostol dalam DOEN akan memastikan ketersediaannya di fasilitas kesehatan di Indonesia, sehingga manajemen PPP di wilayah pedesaan dapat lebih efektif.In Indonesia, postpartum hemorrhage (PPH) continues to be a leading cause of maternal death, especially in rural areas with limited access to oxytocin as the first-line therapy in PPH management. Misoprostol can become an alternative drug for PPH management in rural areas. Literature search was conducted using Google Scholar, PubMed, and NCBI, with keywords including “misoprostol”, “perdarahan pasca persalinan”, “wilayah dengan sumber daya rendah”, “farmakokinetika”, “farmakodinamika”, and “Indonesia”. Evaluation of Cmax, Tmax, and AUC showed that the most effective route of delivery for misoprostol is by sublingual administration. Further research is needed to confirm the most effective delivery route as well as optimal misoprostol dosage for PPH management. However, misoprostol has not been enlisted in Daftar Obat Esensial Nasional (DOEN). Inclusion of misoprostol in DOEN will help ensure its availability in health facilities across Indonesia, towards a more effective management for PPH in rural areas.
Upaya Menurunkan Angka Kematian Ibu akibat Perdarahan Pasca-Persalinan di Indonesia melalui Inovasi Sistem Pelayanan Kesehatan Muhammad Alifian Remifta Putra; Edward Christopher Yo; Jason Phowira; Tricia Dewi Anggraeni
Cermin Dunia Kedokteran Vol. 47 No. 10 (2020): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i10.556

Abstract

Perdarahan pasca-persalinan (PPP) adalah komplikasi persalinan yang menyebabkan 35% seluruh kematian ibu di dunia. Meskipun PPP mulai jarang ditemui di negara maju, kondisi ini masih merupakan salah satu penyebab utama kematian ibu di negara berkembang seperti Indonesia. Hal ini antara lain akibat infastruktur kesehatan yang kurang optimal, sehingga terlambat mengidentifikasi faktor risiko PPP, merujuk, serta memberikan intervensi tepat waktu. Kajian pustaka ini mengamati adanya hubungan signifikan antara penurunan kematian ibu akibat PPP dan implementasi sistem peringatan dini obstetri, manajemen efektif, dan optimalisasi alur rujukan. Namun, karena tiap wilayah memiliki aspek sosioekonomis dan geografis yang berbeda, studi lanjutan diperlukan untuk menentukan pendekatan yang tepat bagi masing-masing wilayah di Indonesia. Postpartum hemorrhage (PPH) is a life-threatening condition that contributes to 35% of all maternal deaths worldwide. Although the risk of PPH has greatly declined in developed countries, it remains a leading cause of maternal mortality in developing countries like Indonesia. This issue could mainly be attributed to poor healthcare system and infrastructure leading to delay in identifying risk factors, referring mothers-at-risk to health centers, and appropriate intervention. We observed a notable relationship between decrease in maternal deaths due to PPH and the implementation of early warning system, effective PPH management, and optimization of referral system. These healthcare innovations showed promising potential in reducing the burden of PPH. However, since there is no single health policy that can be universally implemented, further research is needed to decide the best approach for each area depending on individual, socio-economic and geographic aspects.
Integrasi Misoprostol dalam Daftar Obat Esensial Nasional sebagai Alternatif Penanganan Perdarahan Pasca Persalinan di Wilayah Pedesaan di Indonesia Edward Christopher Yo; Muhammad Alifian Remifta Putra; Jason Phowira
Cermin Dunia Kedokteran Vol. 47 No. 8 (2020): Oftalmologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i8.587

Abstract

Di Indonesia, angka kematian ibu akibat perdarahan pasca persalinan (PPP) masih tinggi, terutama di wilayah pedesaan dengan akses terhadap oksitosin sebagai obat lini utama masih sangat terbatas. Misoprostol berpotensi menjadi alternatif oksitosin untuk penanganan PPP di wilayah pedesaan. Telaah literatur manfaat misoprostol menggunakan search engine Google Scholar, PubMed, dan NCBI, dengan kata kunci “misoprostol”, “perdarahan pasca persalinan”, “wilayah dengan sumber daya rendah”, “farmakokinetika”, “farmakodinamika”, dan “Indonesia”. Ditinjau dari aspek Cmax, Tmax, dan AUC, jalur sublingual diduga paling efektif. Penelitian lebih lanjut diperlukan untuk memastikan rute pemberian serta dosis misoprostol yang paling efektif untuk penanganan kasus PPP. Namun, misoprostol belum terdaftar di Daftar Obat Esensial Nasional (DOEN). Ditetapkannya misoprostol dalam DOEN akan memastikan ketersediaannya di fasilitas kesehatan di Indonesia sehingga manajemen PPP di wilayah pedesaan dapat lebih efektif. In Indonesia, postpartum hemorrhage (PPH) continues to be a leading cause of maternal death, especially in rural areas with limited access to oxytocin as the first-line therapy in PPH management. Misoprostol, a prostaglandin E1 analogue can become an alternative drug for PPH management in rural areas. Literature search was conducted using Google Scholar, PubMed, and NCBI, with keywords including “misoprostol”, “perdarahan pasca persalinan”, “wilayah dengan sumber daya rendah”, “farmakokinetika”, “farmakodinamika”, and “Indonesia”. Evaluation of Cmax, Tmax, and AUC showed that the most effective route of delivery for misoprostol is by sublingual administration. Further research is needed to confirm the most effective delivery route as well as optimal misoprostol dosage for PPH management. However, misoprostol has not been enlisted in Daftar Obat Esensial Nasional (DOEN). Inclusion of misoprostol in DOEN will help ensure its availability in health facilities across Indonesia, towards a more effective management for PPH in rural areas.
Upaya Menurunkan Angka Kematian Ibu akibat Perdarahan Pasca-Persalinan di Indonesia melalui Inovasi Sistem Pelayanan Kesehatan Muhammad Alifian Remifta Putra; Edward Christopher Yo; Jason Phowira; Tricia Dewi Anggraeni
Cermin Dunia Kedokteran Vol 47 No 10 (2020): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i10.556

Abstract

Perdarahan pasca-persalinan (PPP) adalah komplikasi persalinan yang menyebabkan 35% seluruh kematian ibu di dunia. Meskipun PPP mulai jarang ditemui di negara maju, kondisi ini masih merupakan salah satu penyebab utama kematian ibu di negara berkembang seperti Indonesia. Hal ini antara lain akibat infastruktur kesehatan yang kurang optimal, sehingga terlambat mengidentifikasi faktor risiko PPP, merujuk, serta memberikan intervensi tepat waktu. Kajian pustaka ini mengamati adanya hubungan signifikan antara penurunan kematian ibu akibat PPP dan implementasi sistem peringatan dini obstetri, manajemen efektif, dan optimalisasi alur rujukan. Namun, karena tiap wilayah memiliki aspek sosioekonomis dan geografis yang berbeda, studi lanjutan diperlukan untuk menentukan pendekatan yang tepat bagi masing-masing wilayah di Indonesia. Postpartum hemorrhage (PPH) is a life-threatening condition that contributes to 35% of all maternal deaths worldwide. Although the risk of PPH has greatly declined in developed countries, it remains a leading cause of maternal mortality in developing countries like Indonesia. This issue could mainly be attributed to poor healthcare system and infrastructure leading to delay in identifying risk factors, referring mothers-at-risk to health centers, and appropriate intervention. We observed a notable relationship between decrease in maternal deaths due to PPH and the implementation of early warning system, effective PPH management, and optimization of referral system. These healthcare innovations showed promising potential in reducing the burden of PPH. However, since there is no single health policy that can be universally implemented, further research is needed to decide the best approach for each area depending on individual, socio-economic and geographic aspects.
Integrasi Misoprostol dalam Daftar Obat Esensial Nasional sebagai Alternatif Penanganan Perdarahan Pasca Persalinan di Wilayah Pedesaan di Indonesia Edward Christopher Yo; Muhammad Alifian Remifta Putra; Jason Phowira
Cermin Dunia Kedokteran Vol 47 No 8 (2020): Oftalmologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i8.587

Abstract

Di Indonesia, angka kematian ibu akibat perdarahan pasca persalinan (PPP) masih tinggi, terutama di wilayah pedesaan dengan akses terhadap oksitosin sebagai obat lini utama masih sangat terbatas. Misoprostol berpotensi menjadi alternatif oksitosin untuk penanganan PPP di wilayah pedesaan. Telaah literatur manfaat misoprostol menggunakan search engine Google Scholar, PubMed, dan NCBI, dengan kata kunci “misoprostol”, “perdarahan pasca persalinan”, “wilayah dengan sumber daya rendah”, “farmakokinetika”, “farmakodinamika”, dan “Indonesia”. Ditinjau dari aspek Cmax, Tmax, dan AUC, jalur sublingual diduga paling efektif. Penelitian lebih lanjut diperlukan untuk memastikan rute pemberian serta dosis misoprostol yang paling efektif untuk penanganan kasus PPP. Namun, misoprostol belum terdaftar di Daftar Obat Esensial Nasional (DOEN). Ditetapkannya misoprostol dalam DOEN akan memastikan ketersediaannya di fasilitas kesehatan di Indonesia sehingga manajemen PPP di wilayah pedesaan dapat lebih efektif. In Indonesia, postpartum hemorrhage (PPH) continues to be a leading cause of maternal death, especially in rural areas with limited access to oxytocin as the first-line therapy in PPH management. Misoprostol, a prostaglandin E1 analogue can become an alternative drug for PPH management in rural areas. Literature search was conducted using Google Scholar, PubMed, and NCBI, with keywords including “misoprostol”, “perdarahan pasca persalinan”, “wilayah dengan sumber daya rendah”, “farmakokinetika”, “farmakodinamika”, and “Indonesia”. Evaluation of Cmax, Tmax, and AUC showed that the most effective route of delivery for misoprostol is by sublingual administration. Further research is needed to confirm the most effective delivery route as well as optimal misoprostol dosage for PPH management. However, misoprostol has not been enlisted in Daftar Obat Esensial Nasional (DOEN). Inclusion of misoprostol in DOEN will help ensure its availability in health facilities across Indonesia, towards a more effective management for PPH in rural areas.
Co-Authors Edward Christopher Yo Muhammad Alifian Remifta Putra Tricia Dewi Anggraeni