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Johan Indra Lukito
Medical Department, PT. Kalbe Farma Tbk. Jakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Tinjauan atas Glucagon-like peptide-1 receptor agonist Johan Indra Lukito
Cermin Dunia Kedokteran Vol 47, No 8 (2020): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i8.780

Abstract

GLP-1 receptor agonist secara struktur mirip hormon alami GLP-1 yang memiliki efek incretin, namun degradasinya dapat dicegah oleh DPP-4. Saat ini terdapat 8 jenis yang terdiri dari exenatide, exenatide ER, liraglutide, albiglutide, dulaglutide, lixisenatide, semaglutide injeksi, dan semaglitode oral. GLP-1 receptor agonist merupakan pilihan pengobatan DM tipe 2 baik sebagai tambahan maupun sebagai monoterapi.The GLP-1 receptor agonist is structurally similar to the natural hormone GLP-1 which has an incretin effect but prevented from breakdown by DPP-4. There are currently 8 types of GLP-1 : exenatide, exenatide ER, liraglutide, albiglutide, dulaglutide, lixisenatide, injection semaglutide , and oral semaglutide. GLP-1 receptor agonist is an option for the treatment of type 2 DM both as adjunctive and as monotherapy.
Pengembangan Aplikasi Seluler Kesehatan terkait Diabetes Melitus Johan Indra Lukito
Cermin Dunia Kedokteran Vol 48, No 10 (2021): CME - Continuing Medical Education
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i10.1516

Abstract

Peningkatan kualitas hidup pasien diabetes melitus (DM) membutuhkan pengelolaan komprehensif. Beberapa tantangan dihadapi baik oleh pasien maupun profesional kesehatan dalam tatalaksana DM. Penggunaan dan pengembangan aplikasi seluler kesehatan berbasis telemedicine dan teknologi informasi kesehatan diharapkan dapat membantu mengatasi tantangan ini.Improving the quality of life of patients with diabetes mellitus (DM) requires comprehensive management. Several challenges are faced by both patients and health professionals in the management of DM. It is hoped that the use and development of mobile health applications based on telemedicine and health information technology can help overcome this challenge.
Tinjauan Antivirus untuk Terapi COVID-19 Johan Indra Lukito
Cermin Dunia Kedokteran Vol 47, No 7 (2020): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i7.595

Abstract

COVID-19 merupakan penyakit yang disebabkan oleh coronavirus baru yang disebut SARS-CoV-2. Pada 11 Maret 2020, WHO mendeklarasikan COVID-19 sebagai pandemi global. Beberapa jenis antivirus diteliti potensinya sebagai terapi untuk COVID-19, di antaranya yaitu: oseltamivir, favipiravir, remdesivir, lopinavir+ritonavir, atazanavir, nelfinavir, saquinavir, tipranavir, darunavir, umifenovir, dan baloxavir.COVID-19 is a disease caused by a new coronavirus called SARS-CoV-2. On March 11, 2020, WHO declared COVID-19 as a global pandemic. Several types of antivirals have been investigated for their potential as therapies for COVID-19, including: oseltamivir, favipiravir, remdesivir, lopinavir+ritonavir, atazanavir, nelfinavir, saquinavir, tipranavir, darunavir, umifenovir, dan baloxavir.
Gunakan Insulin dengan CERMAT Johan Indra Lukito
Cermin Dunia Kedokteran Vol 47, No 10 (2020): Optalmologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i10.1093

Abstract

Insulin digunakan sebagai salah satu terapi diabetes melitus (DM). Penderita DM dan keluarganya perlu mendapat edukasi tentang penggunaan insulin. Penulis menyusun sebuah mnemonik untuk membantu pasien dan keluarganya mengingat hal-hal penting terkait penggunaan insulin. Mnemonik ini berupa slogan “Gunakan Insulin dengan CERMAT”.Insulin is used for diabetes mellitus (DM) therapy. DM sufferers and their families need to be educated on using insulin to control their blood glucose levels. The author suggested a mnemonic to help patients and their families remember essential points related to insulin use. This mnemonic is "Use Insulin with CERMAT". 
Tatalaksana Monkeypox Johan Indra Lukito
Cermin Dunia Kedokteran Vol 46, No 8 (2019): Kesehatan Anak
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i8.447

Abstract

Monkeypox merupakan penyakit zoonosis akibat virus yang terjadi terutama di daerah hutan hujan tropis Afrika tengah dan barat. Virus monkeypox mirip cacar. Meskipun monkeypox jauh lebih ringan daripada cacar, namun dapat fatal. Virus monkeypox sebagian besar ditularkan ke manusia dari berbagai binatang liar seperti tikus dan primata, juga dapat ditularkan dari manusia ke manusia. Tingkat kematian saat wabah monkeypox antara 1% - 10%, sebagian besar pada kelompok usia lebih muda. Tidak ada pengobatan atau vaksin khusus namun vaksinasi cacar sangat efektif mencegah monkeypox.Monkeypox is a viral zoonotic disease that occurs primarily in remote tropical rainforests of central and west Africa. The monkeypox virus is similar to human smallpox virus. Although monkeypox is much milder than smallpox, it can also be fatal. Monkeypox virus is mostly transmitted to people from various wild animals such as rodents and primates, it can also spread through human-to-human transmission. Case fatality in monkeypox outbreaks is between 1% - 10%, most deaths occurred in younger age groups. No specific treatment or vaccine available, although smallpox vaccination was also highly effective in preventing monkeypox.
Tinjauan atas Terapi Insulin Johan Indra Lukito
Cermin Dunia Kedokteran Vol 47, No 9 (2020): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i9.917

Abstract

Tujuan terapi insulin adalah meniru pola sekresi insulin endogen individu normal. Berbagai jenis insulin dapat dibagi menjadi 3 kelompok utama : insulin kerja cepat/pendek, insulin kerja menengah dan insulin kerja panjang. Pemilihan regimen insulin disesuaikan dengan berbagai kondisi dan kebutuhan.The goal of insulin therapy is to mimic the pattern of normal endogenous insulin secretion. Various types of insulin can be divided into 3 main groups: fast/short-acting insulin, intermediate-acting insulin, and long-acting insulin. The choice of insulin regimen is adapted to various conditions and needs.
Antifungal Echinocandin Johan Indra Lukito
Cermin Dunia Kedokteran Vol 46, No 2 (2019): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i2.525

Abstract

Infeksi fungal invasif (IFI) masih menjadi penyebab utama morbiditas dan mortalitas pasien immunocompromised. Pilihan antifungal yang tersedia untuk IFI terbatas pada polyene, triazole, dan echinocandin. Echinocandin, yang terdiri dari caspofungin, micafungin, dan anidulafungin, merupakan golongan antifungal terbaru yang saat ini banyak digunakan untuk pengobatan IFI. Echinocandin memiliki beberapa keunggulan seperti aktivitas fungisidal yang poten terhadap sebagian besar spesies Candida, rendahnya resistensi, profil keamanan yang lebih baik serta interaksi dengan obat lain yang lebih sedikit.Invasive fungal infection (IFI) is still a major cause of morbidity and mortality in immunocompromised patients. The antifungal choices available for IFI are limited to polyene, triazole, and echinocandin. Echinocandin, which consists of caspofungin, micafungin, and anidulafungin, is the newest class of antifungal which is currently widely used for the treatment of IFI. Echinocandin has several advantages such as potent fungicidal activity against most Candida species, low resistance, better safety profile and fewer drug interaction.
Tinjauan Antivirus untuk Terapi COVID-19 Johan Indra Lukito
Cermin Dunia Kedokteran Vol. 47 No. 5 (2020): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i5.376

Abstract

COVID-19 merupakan penyakit yang disebabkan oleh coronavirus baru yang disebut SARS-CoV-2. Pada 11 Maret 2020, WHO mendeklarasikan COVID-19 sebagai pandemi global. Beberapa jenis antivirus diteliti potensinya sebagai terapi untuk COVID-19, di antaranya: oseltamivir, favipiravir, remdesivir, lopinavir+ritonavir, atazanavir, nelfinavir, saquinavir, tipranavir, darunavir, umifenovir, dan baloxavir. COVID-19 is a disease caused by a new coronavirus called SARS-CoV-2. On March 11, 2020, WHO declared COVID-19 as a global pandemic. Several types of antivirals have been investigated for their potential as therapies for COVID-19, including: oseltamivir, favipiravir, remdesivir, lopinavir+ritonavir, atazanavir, nelfinavir, saquinavir, tipranavir, darunavir, umifenovir, dan baloxavir.
Antibiotik Profilaksis pada Tindakan Bedah Johan Indra Lukito
Cermin Dunia Kedokteran Vol 46 No 12 (2019): Kardiovakular
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i12.398

Abstract

Antibiotik profilaksis pra-operasi didefinisikan sebagai pemberian antibiotik sebelum operasi untuk mengurangi risiko infeksi pasca-operasi. Antibiotik profilaksis optimal untuk pembedahan idealnya sesuai pedoman penggunaan antibiotik profilaksis atau pedoman lokal. Kriteria antibiotik profilaksis dalam pembedahan yang tepat meliputi tepat indikasi, tepat jenis antibiotik, tepat dosis, tepat rute, tepat waktu, dan durasi pemberian. Pre-operative antibiotic prophylaxis is defined as administration of antibiotics prior to surgical procedure to decrease postoperative infection risk. The optimal antibiotic prophylaxis for surgery is ideally in accordance with the guidelines. The key elements of appropriate surgical antimicrobial prophylaxis prescribing include correct indication, antimicrobial, drug dose, route, timing of administration, and duration.
Tatalaksana Monkeypox Johan Indra Lukito
Cermin Dunia Kedokteran Vol. 46 No. 8 (2019): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i8.423

Abstract

Monkeypox merupakan penyakit zoonosis akibat virus yang terjadi terutama di daerah hutan hujan tropis Afrika tengah dan barat. Virus monkeypox mirip cacar. Meskipun monkeypox jauh lebih ringan daripada cacar, namun dapat fatal. Virus monkeypox sebagian besar ditularkan ke manusia dari berbagai binatang liar seperti tikus dan primata, juga dapat ditularkan dari manusia ke manusia. Tingkat kematian saat terjadinya wabah monkeypox antara 1% - 10%, sebagian besar pada kelompok usia lebih muda. Tidak ada pengobatan atau vaksin khusus, namun vaksinasi cacar sangat efektif mencegah monkeypox. Monkeypox is a viral zoonotic disease that occurs primarily in remote tropical rainforests of central and west Africa. The monkeypox virus is similar to human smallpox virus. Although monkeypox is much milder than smallpox, it can also be fatal. Monkeypox virus is mostly transmitted to people from various wild animals such as rodents and primates; it can also spread through human-to-human transmission. Case fatality in monkeypox outbreaks is within 1% - 10%, most deaths occurred in younger age groups. No specific treatment or vaccine available, although smallpox vaccination was also highly effective in preventing monkeypox.
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