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Putu Stephanie Apriliana Hardika
Klinik Artha Medika, Badung, Bali, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Sindrom Felty – Diagnosis dan Tata Laksana Putu Stephanie Apriliana Hardika
Cermin Dunia Kedokteran Vol 49, No 1 (2022): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.1638

Abstract

Sindrom Felty merupakan kondisi medis dengan karakteristik trias yaitu artritis reumatoid, neutropenia, dan splenomegali; terjadi pada beberapa kasus artritis reumatoid erosif yang sudah berlangsung lama. Hanya 1 – 3% pasien artritis reumatoid akan berkembang menjadi Sindrom Felty. Peran genetik (HLA-DR4) dan faktor lingkungan berperan dalam terjadinya kondisi ini. Neutropenia persisten dengan hitung neutrofil absolut umumnya kurang dari 1500/mm3 merupakan ciri khas diagnosis Sindrom Felty. Kondisi medis ini biasanya asimtomatik, infeksi lokal serius atau sistemik bisa menjadi petunjuk awal. Terapi farmakologi menggunakan disease-modifying anti-rheumatic drugs (DMARDs); methotrexate oral dosis rendah menjadi modalitas terapi lini pertama. Splenektomi merupakan upaya terakhir dalam algoritma penatalaksanaan Sindrom Felty. Felty Syndrome is a medical condition characterized by triad of rheumatoid arthritis, neutropenia, and splenomegaly; occurs in few cases of longstanding erosive rheumatoid arthritis. Only 1 – 3% rheumatoid arthritis patient developed Felty Syndrome. Genetic (HLA-DR4) and environmental factors are involved in its pathophysiology. Persistent neutropenia with absolute neutrophil count less than 1500/mm3 is a diagnosis hallmark. Felty syndrome may be asymptomatic, but local serious or systemic infections may be the first clue to the diagnosis. Pharmacological therapy as the first-line therapy use disease-modifying anti-rheumatic drugs (DMARDs) such as oral low dose methotrexate. Surgical approach (splenectomy) is the last resort in Felty Syndrome management.
Sindrom Rapunzel – Diagnosis dan Tatalaksana Putu Stephanie Apriliana Hardika
Cermin Dunia Kedokteran Vol 48, No 9 (2021): Nyeri Neuropatik
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i9.1491

Abstract

Sindrom Rapunzel merupakan kondisi medis terdapatnya massa (gumpalan) rambut yang terperangkap di gaster atau sampai menuju usus halus. Gangguan psikiatri trikotilomania dan trikofagia menjadi faktor predisposisi gastric trichobezoar. Kondisi ini dominan ditemukan pada remaja perempuan. Manifestasi klinis biasanya non-spesifik berupa nyeri abdomen, mual, dan muntah. Endoskopi menjadi baku emas diagnosis. Metode endoskopi dan open surgery merupakan pilihan modalitas pengangkatan massa (trichobezoar). Pendekatan multidisiplin evaluasi psikiatri berkala sangat perlu guna mencegah berulang.Rapunzel Syndrome is a medical condition of solid mass (accumulation) of hair in stomach and may extend to small intestine. Psychiatric disorders, such as trichotillomania and trichophagia, are two predisposition factors for gastric trichobezoar. This condition is predominantly found in young female. Clinical manifestation is usually non-specific gastrointestinal symptoms, like abdominal pain, nausea, and vomiting. Endoscopic examination is the gold standard for diagnosis. The main management is removal by endoscopy or open surgery. Multidiscipline approach including regular follow up and psychiatric evaluation is required to prevent its recurrence.
Sindrom Rapunzel – Diagnosis dan Tatalaksana Putu Stephanie Apriliana Hardika
Cermin Dunia Kedokteran Vol 48 No 9 (2021): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i9.124

Abstract

Sindrom Rapunzel merupakan kondisi medis terdapatnya massa (gumpalan) rambut yang terperangkap di gaster atau sampai menuju usus halus. Gangguan psikiatri trikotilomania dan trikofagia menjadi faktor predisposisi gastric trichobezoar. Kondisi ini dominan ditemukan pada remaja perempuan. Manifestasi klinis biasanya non-spesifik berupa nyeri abdomen, mual, dan muntah. Endoskopi menjadi baku emas diagnosis. Metode endoskopi dan open surgery merupakan pilihan modalitas pengangkatan massa (trichobezoar). Pendekatan multidisiplin evaluasi psikiatri berkala sangat perlu guna mencegah berulang. Rapunzel Syndrome is a medical condition of solid mass (accumulation) of hair in stomach and may extend to small intestine. Psychiatric disorders, such as trichotillomania and trichophagia, are two predisposition factors for gastric trichobezoar. This condition is predominantly found in young female. Clinical manifestation is usually non-specific gastrointestinal symptoms, like abdominal pain, nausea, and vomiting. Endoscopic examination is the gold standard for diagnosis. The main management is removal by endoscopy or open surgery. Multidiscipline approach including regular follow up and psychiatric evaluation is required to prevent its recurrence.
Sindrom Felty – Diagnosis dan Tata Laksana Putu Stephanie Apriliana Hardika
Cermin Dunia Kedokteran Vol 49 No 1 (2022): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.181

Abstract

Sindrom Felty merupakan kondisi medis dengan karakteristik trias yaitu artritis reumatoid, neutropenia, dan splenomegali; terjadi pada beberapa kasus artritis reumatoid erosif yang sudah berlangsung lama. Hanya 1 – 3% pasien artritis reumatoid akan berkembang menjadi Sindrom Felty. Genetik (HLA-DR4) dan faktor lingkungan berperan dalam terjadinya kondisi ini. Neutropenia persisten dengan hitung neutrofil absolut umumnya kurang dari 1500/mm3 merupakan ciri khas diagnosis Sindrom Felty. Kondisi medis ini biasanya asimtomatik, infeksi lokal serius atau sistemik bisa menjadi petunjuk awal. Terapi farmakologi menggunakan disease-modifying anti-rheumatic drugs (DMARDs); methotrexate oral dosis rendah menjadi modalitas terapi lini pertama. Splenektomi merupakan upaya terakhir dalam algoritma penatalaksanaan Sindrom Felty. Felty Syndrome is a medical condition characterized by triad of rheumatoid arthritis, neutropenia, and splenomegaly; occurs in few cases of longstanding erosive rheumatoid arthritis. Only 1 – 3% rheumatoid arthritis patient developed Felty Syndrome. Genetic (HLA-DR4) and environmental factors are involved in its pathophysiology. Persistent neutropenia with absolute neutrophil count less than 1500/mm3 is a diagnosis hallmark. Felty syndrome may be asymptomatic, but local serious or systemic infections may be the first clue to the diagnosis. Pharmacological therapy as the first-line therapy use disease-modifying anti-rheumatic drugs (DMARDs) such as oral low dose methotrexate. Surgical approach (splenectomy) is the last resort in Felty Syndrome management.
Sindrom Rapunzel – Diagnosis dan Tatalaksana Putu Stephanie Apriliana Hardika
Cermin Dunia Kedokteran Vol 48 No 9 (2021): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i9.124

Abstract

Sindrom Rapunzel merupakan kondisi medis terdapatnya massa (gumpalan) rambut yang terperangkap di gaster atau sampai menuju usus halus. Gangguan psikiatri trikotilomania dan trikofagia menjadi faktor predisposisi gastric trichobezoar. Kondisi ini dominan ditemukan pada remaja perempuan. Manifestasi klinis biasanya non-spesifik berupa nyeri abdomen, mual, dan muntah. Endoskopi menjadi baku emas diagnosis. Metode endoskopi dan open surgery merupakan pilihan modalitas pengangkatan massa (trichobezoar). Pendekatan multidisiplin evaluasi psikiatri berkala sangat perlu guna mencegah berulang. Rapunzel Syndrome is a medical condition of solid mass (accumulation) of hair in stomach and may extend to small intestine. Psychiatric disorders, such as trichotillomania and trichophagia, are two predisposition factors for gastric trichobezoar. This condition is predominantly found in young female. Clinical manifestation is usually non-specific gastrointestinal symptoms, like abdominal pain, nausea, and vomiting. Endoscopic examination is the gold standard for diagnosis. The main management is removal by endoscopy or open surgery. Multidiscipline approach including regular follow up and psychiatric evaluation is required to prevent its recurrence.
Sindrom Felty – Diagnosis dan Tata Laksana Putu Stephanie Apriliana Hardika
Cermin Dunia Kedokteran Vol 49 No 1 (2022): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.181

Abstract

Sindrom Felty merupakan kondisi medis dengan karakteristik trias yaitu artritis reumatoid, neutropenia, dan splenomegali; terjadi pada beberapa kasus artritis reumatoid erosif yang sudah berlangsung lama. Hanya 1 – 3% pasien artritis reumatoid akan berkembang menjadi Sindrom Felty. Genetik (HLA-DR4) dan faktor lingkungan berperan dalam terjadinya kondisi ini. Neutropenia persisten dengan hitung neutrofil absolut umumnya kurang dari 1500/mm3 merupakan ciri khas diagnosis Sindrom Felty. Kondisi medis ini biasanya asimtomatik, infeksi lokal serius atau sistemik bisa menjadi petunjuk awal. Terapi farmakologi menggunakan disease-modifying anti-rheumatic drugs (DMARDs); methotrexate oral dosis rendah menjadi modalitas terapi lini pertama. Splenektomi merupakan upaya terakhir dalam algoritma penatalaksanaan Sindrom Felty. Felty Syndrome is a medical condition characterized by triad of rheumatoid arthritis, neutropenia, and splenomegaly; occurs in few cases of longstanding erosive rheumatoid arthritis. Only 1 – 3% rheumatoid arthritis patient developed Felty Syndrome. Genetic (HLA-DR4) and environmental factors are involved in its pathophysiology. Persistent neutropenia with absolute neutrophil count less than 1500/mm3 is a diagnosis hallmark. Felty syndrome may be asymptomatic, but local serious or systemic infections may be the first clue to the diagnosis. Pharmacological therapy as the first-line therapy use disease-modifying anti-rheumatic drugs (DMARDs) such as oral low dose methotrexate. Surgical approach (splenectomy) is the last resort in Felty Syndrome management.
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