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Nelly Rosdiana
Divisi Hematologi-Onkologi Departemen Anak. Fakultas Kedokteran Universitas Sumatera Utara - RSUP Haji Adam Malik, Medan, Sumatera Utara, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Atherosklerosis Prematur dan Dislipidemi pada Anak Penyandang Thalassemia Beta Mayor Christian Nasir; Nelly Rosdiana
Cermin Dunia Kedokteran Vol 45, No 5 (2018): Nutrisi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i5.678

Abstract

Atherosklerosis adalah penyakit progresif lambat yang ditandai oleh penebalan bertahap tunika intima. Faktor pemicu atherosklerosis prematur adalah hemolisis kronis, peningkatan kadar zat besi, dan dislipidemi. Atherosklerosis prematur adalah salah satu komplikasi kardiovaskular penting pada penyandang thalassemia beta mayor. Pada penyandang thalassemia beta, kadar kolesterol total, HDL, dan LDL lebih rendah; sebaliknya kadar trigliserida lebih tinggi dibandingkan individu normal. Dislipidemi pada thalassemia beta disebabkan berbagai faktor, antara lain dilusi plasma akibat anemia, meningkatnya aktivitas eritropoeisis, gangguan fungsi hati karena penimbunan zat besi, gangguan hormonal, dan menurunnya aktivitas lipolisis di luar hati.Atherosclerosis is a slow progressive disease characterized by gradual intimal thickening. The predisposing factors for premature atherosclerosis are chronic hemolysis, increased serum iron deposit, and dyslipidemia. Premature atherosclerosis has emerged as important cardiovascular complication in beta-thalassemia major. Beta-thalassemia is associated with lower total cholesterol, LDL, and HDL, and higher triglyceride level. Dyslipidemia in beta-thalassemia is caused by several factors, such as plasma dilution due to anemia, increased erythropoietic activity, liver injury due to iron overload, hormonal disturbance, and decreased extra hepatic lipolysis activity.
Co-Authors Christian Nasir