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Natalia Sisca Wijaya
Mitra Kemayoran Hospital, Jakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Ivermectin as a Potential Therapeutic Agent for COVID-19 – case studies Natalia Sisca Wijaya; Sidharta Salim
Cermin Dunia Kedokteran Vol 47, No 7 (2020): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i7.601

Abstract

In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) started in Wuhan, China, and has since become a global threat to human health. To dates, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. Several types of drug as well as vaccination are still under investigation and clinical trials worldwide. Recently, a study demonstrated ~5000-fold reduction in SARS-CoV-2 virus at 48h in cell culture after a single treatment of ivermectin. A clinical study at University of Utah found that the administration of ivermectin during COVID-19 illness in hospitalized patients is associated with lower mortality and hospital length of stay. We report three confirmed cases of COVID-19 infection with significant improvement clinically and radiologically following treatment with single dose of ivermectin.Pada Desember 2019, wabah yang disebabkan oleh varian baru coronavirus (SARS-CoV-2) dimulai di Wuhan, China, dan saat ini telah menjadi ancaman global bagi kesehatan manusia.Hingga saat ini, respon dunia terhadap wabah COVID-19 masih terbatas pada pemantauan dan isolasi. Di seluruh dunia, beberapa jenis obat dan juga vaksinasi masih menjalani tahap investigasi dan uji klinis. Baru-baru ini, sebuah studi mendemonstrasikan bahwa satu dosis ivermectin mampu mengurangi ~5000-kali kadar SARS-CoV-2 virus dalam 48 jam pada kultur sel. Sebuah uji klinis di Universitas di Utah juga membuktikan bahwa ivermectin terbukti menurunkan angka mortalitas dan juga lama perawatan pasien COVID-19 rawat inap. Kami melaporkan tiga pasien dengan konfirmasi positif COVID-19 yang menunjukkan kemajuan signifikan klinis dan radiologis setelah pengobatan dengan satu dosis ivermectin.
Falciform Ligament Abscess in Adult, Resolving without Surgical Treatment Natalia Sisca Wijaya; Sidharta Salim
Cermin Dunia Kedokteran Vol 47 No 1 (2020): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i1.15

Abstract

A 59 year-old female presented with a one-month history of abdominal discomfort, nausea, vomiting, weight loss, and a palpable mass on her epigastrium area. Initial history, physical examination, and work up lead to a diagnosis of gastric malignancy. However; discharge of purulent secretion from the biopsy site and biopsy results of PMN infiltration leads to a diagnosis of abscess. Culture subsequently showed E. coli. The patient was not amenable to surgical procedure hence was treated with third generation cephalosporin antibiotic as guided by culture results. After one month of antibiotic treatment, the abscess was completely resolved. This case presents the first falciform ligament abscess following enteritis; resolving with a non-surgical approach. Seorang wanita 59 tahun datang dengan keluhan nyeri perut, mual, muntah, penurunan berat badan, dan massa epigastrik sejak satu bulan. Anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang mengarah kepada diagnosis keganasan lambung. Akan tetapi, adanya sekret purulen dari lokasi biopsi dan hasil biopsi yang menunjukkan infiltrasi PMN mencurigakan diagnosis abses. Kultur pus menunjukkan E. coli. Pasien tidak menyetujui tindakan operasi, sehingga diterapi konservatif menggunakan antibiotik cephalosporin generasi ketiga sesuai pola resistensi dari hasil kultur. Setelah satu bulan pemberian antibiotik, abses sepenuhnya menghilang. Artikel ini mempresentasikan kasus pertama abses ligamentum falciform setelah enteritis; yang teratasi tanpa terapi bedah.
Ivermectin as a Potential Therapeutic Agent for COVID-19 – case studies Natalia Sisca Wijaya; Sidharta Salim
Cermin Dunia Kedokteran Vol. 47 No. 5 (2020): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i5.382

Abstract

In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) started in Wuhan, China, and has since become a global threat to human health. To date, the worldwide response to the COVID-19 outbreak has been limited mainly to monitoring/containment. Several types of drug, as well as vaccination, are still under investigation and clinical trials worldwide. Recently, a study demonstrated ~5000-fold reduction in SARSCoV-2 virus at 48h in cell culture after a single treatment of ivermectin. A clinical study at the University of Utah found that the administration of ivermectin during COVID-19 illness in hospitalized patients is associated with lower mortality and hospital length of stay. We report three confirmed cases of COVID-19 infection with significant improvement clinically and radiologically, with following treatment single dose of ivermectin. Pada Desember 2019, wabah yang disebabkan oleh varian baru coronavirus (SARS-CoV-2) dimulai di Wuhan, China, dan saat ini telah menjadi ancaman global bagi kesehatan manusia. Hingga saat ini, respons dunia terhadap wabah COVID-19 masih terbatas pada pemantauan dan isolasi. Di seluruh dunia, beberapa jenis obat dan juga vaksinasi masih menjalani tahap investigasi dan uji klinis. Baru-baru ini, sebuah studi mendemonstrasikan bahwa satu dosis ivermectin mampu mengurangi ~5000-kali kadar SARS-CoV-2 virus dalam 48 jam pada kultur sel. Sebuah uji klinis di Universitas di Utah juga membuktikan bahwa ivermectin terbukti menurunkan angka mortalitas dan juga lama perawatan pasien COVID-19 rawat inap. Kami melaporkan tiga pasien dengan konfirmasi positif COVID-19 yang menunjukkan kemajuan signifikan klinis dan radiologis setelah pengobatan dengan satu dosis ivermectin.
Falciform Ligament Abscess in Adult, Resolving without Surgical Treatment Natalia Sisca Wijaya; Sidharta Salim
Cermin Dunia Kedokteran Vol 47 No 1 (2020): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i1.15

Abstract

A 59 year-old female presented with a one-month history of abdominal discomfort, nausea, vomiting, weight loss, and a palpable mass on her epigastrium area. Initial history, physical examination, and work up lead to a diagnosis of gastric malignancy. However; discharge of purulent secretion from the biopsy site and biopsy results of PMN infiltration leads to a diagnosis of abscess. Culture subsequently showed E. coli. The patient was not amenable to surgical procedure hence was treated with third generation cephalosporin antibiotic as guided by culture results. After one month of antibiotic treatment, the abscess was completely resolved. This case presents the first falciform ligament abscess following enteritis; resolving with a non-surgical approach. Seorang wanita 59 tahun datang dengan keluhan nyeri perut, mual, muntah, penurunan berat badan, dan massa epigastrik sejak satu bulan. Anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang mengarah kepada diagnosis keganasan lambung. Akan tetapi, adanya sekret purulen dari lokasi biopsi dan hasil biopsi yang menunjukkan infiltrasi PMN mencurigakan diagnosis abses. Kultur pus menunjukkan E. coli. Pasien tidak menyetujui tindakan operasi, sehingga diterapi konservatif menggunakan antibiotik cephalosporin generasi ketiga sesuai pola resistensi dari hasil kultur. Setelah satu bulan pemberian antibiotik, abses sepenuhnya menghilang. Artikel ini mempresentasikan kasus pertama abses ligamentum falciform setelah enteritis; yang teratasi tanpa terapi bedah.
Ivermectin as a Potential Therapeutic Agent for COVID-19 – case studies Natalia Sisca Wijaya; Sidharta Salim
Cermin Dunia Kedokteran Vol 47 No 5 (2020): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i5.382

Abstract

In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) started in Wuhan, China, and has since become a global threat to human health. To date, the worldwide response to the COVID-19 outbreak has been limited mainly to monitoring/containment. Several types of drug, as well as vaccination, are still under investigation and clinical trials worldwide. Recently, a study demonstrated ~5000-fold reduction in SARSCoV-2 virus at 48h in cell culture after a single treatment of ivermectin. A clinical study at the University of Utah found that the administration of ivermectin during COVID-19 illness in hospitalized patients is associated with lower mortality and hospital length of stay. We report three confirmed cases of COVID-19 infection with significant improvement clinically and radiologically, with following treatment single dose of ivermectin. Pada Desember 2019, wabah yang disebabkan oleh varian baru coronavirus (SARS-CoV-2) dimulai di Wuhan, China, dan saat ini telah menjadi ancaman global bagi kesehatan manusia. Hingga saat ini, respons dunia terhadap wabah COVID-19 masih terbatas pada pemantauan dan isolasi. Di seluruh dunia, beberapa jenis obat dan juga vaksinasi masih menjalani tahap investigasi dan uji klinis. Baru-baru ini, sebuah studi mendemonstrasikan bahwa satu dosis ivermectin mampu mengurangi ~5000-kali kadar SARS-CoV-2 virus dalam 48 jam pada kultur sel. Sebuah uji klinis di Universitas di Utah juga membuktikan bahwa ivermectin terbukti menurunkan angka mortalitas dan juga lama perawatan pasien COVID-19 rawat inap. Kami melaporkan tiga pasien dengan konfirmasi positif COVID-19 yang menunjukkan kemajuan signifikan klinis dan radiologis setelah pengobatan dengan satu dosis ivermectin.
Co-Authors Sidharta Salim