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Rizaldy Pinzon
Unit Epidemiologi Klinik dan Biostatistik, Fakultas Kedokteran Universitas Gadjah Mada, Yogyakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Terapi Rasional Nyeri Neuropatik Rizaldy Pinzon
Cermin Dunia Kedokteran Vol 41, No 3 (2014): Farmakologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v41i3.1159

Abstract

Nyeri neuropatik dapat terjadi akibat lesi atau penyakit yang mengenai sistem somatosensorik. Penatalaksanaan nyeri neuropatik kronik masih sulit sekalipun sudah dilakukan sejumlah upaya untuk menghasilkan pendekatan terapi yang lebih rasional. Penggunaan NNT (number needed to treat) dan NNH (number needed to harm) patut dipertimbangkan dalam memilih obat untuk seorang pasien. Gabapentin, pregabalin, dan antidepresan trisiklik (tricyclic antidepressant, TCA) adalah obat-obat yang paling sering diteliti dan layak dipandang sebagai pilihan pertama dalam terapi nyeri neuropatik.Neuropathic pain may arise as a consequence of a lesion or disease affecting the somatosensory system. The management of chronic neuropathic pain is challenging, despite several attempts to develop a more rational therapeutic approach. The use of NNT (number needed to treat) and NNH (number needed to harm) should be considered for choosing the medications for individual patients. Gabapentin, pregabalin and TCA (tricyclic antidepressant) were the most frequently studied drugs and should be considered as first choices in treating neuropathic pain. 
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