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disca sandyakala
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Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Veterinary

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Inovation Of Collagen Based Corneal Hydrogel with the Addition Of Glycopolymer As the Solution For Irreversible Blindness By Corneal Ulcers disca sandyakala
Journal of Stem Cell Research and Tissue Engineering Vol. 3 No. 2 (2019): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v3i2.20134

Abstract

Indonesian Health Ministry  Data showed that 5.3% of 100,000 population in Indonesia suffer from corneal ulcers. Corneal ulcer is one of the five leading causes of largest blindness  morbidity and loss of vision. Corneal transplant being the only medicine accepted widely despite there are many post-surgery complications. The study was conducted to review the initials make a synthetic cornea from natural ingredients collagen type I composite with a glikopolimer from poly (1,8-octanediol-co-citrate) (POC) and poly (vynyl-alcohol) (PVA) hydrogels form to review increase the strength of mechanical and biodegradibilty as candidate synthetic cornea. The result of Fourier Transform Infra Red (FTIR) tin that strong cross Occurs on Force C = O stretching Which is a cluster formation of ester IN 1735 cm-1. The result of tensile test showed that the value of elasticity modulus tends to decrease with increasing concentration of collagen with modulus of elasticity in a row for a review variation collagen 1%, 3%, and 5% is 13.26 MPa, 13.21 MPa, and 11.5 MPa. Moisture balance test results Phosphate Buffer Saline (PBS) for 7 days for a review sample of collagen Variation 1%, 3%, and 5% is 89%, 91% and 92%. Spectroscopic test results showed that all the various samples can continue light until appoximately 98% accordance to standart of cornea. The synthetic cornea from collagen type 1 and glycopolymer from poly(1,8-octanediol-co-citrate) (POC) and poly(vynyl alcohol) (PVA) have a potential to be solution for irreversible blindness caused by corneal ulcers.
The Effect of Poly (Vynil Pyrrolidine) (PVP) Added in Variation of Ca2+ and PO43- Concentration in Microbial Cellulose-Hydroxyapatite Composite As Scaffold For Bone Healing disca sandyakala
Journal of Stem Cell Research and Tissue Engineering Vol. 3 No. 2 (2019): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v3i2.20358

Abstract

In Indonesia, the traffic accident causing 6 million people suffered injuries, particularly injuries fractures. 46.2% incidence of fractures occur in the lower extremities, 25% of them dying, 45% had a physical disability, 15% experienced psychological pressure and only 10% were healed well. Implant (graft) are used to support and accelerate the healing process of broken bones (bone healing). This study was done to make microbial cellulose-hydroxyapatite scaffold as a candidate for bone healing. Microbial cellulose obtained from culturing Acetobacter xylinum is used as a matrix and hydroxyapatite as a filler that is synthesized using the method of immersion in a solution of CaCl2 and KH2PO4, to increase the formation of apatite crystals, added polyvinyl Pyrrolidine (PVP). Scaffold synthesized using methods of freeze dried. Formation of composites varied in the concentration of Ca2+ and PO 3- of 25:125; 50:100; 75:75; 100:50 mM. The samples were then characterized using FTIR spectroscopy which shows the phosphate groups and the carbonate indicates the formation of hydroxyapatite in the eighth sample. Furthermore, to determine the morphology and identify the elements in the scaffold used SEM-EDAX, it was found that the pore formed measuring about 150-300 μm and obtained ratio of Ca / P best on microbial cellulose scaffold-PVP-hydroxyapatite with a variation of the concentration of Ca2+ and PO43- of 100 : 50 mM is equal to 0.6046 with an average degradation rate of 18.617% and the percentage of porosity contained in the sample amounted to 88.4%. This proves that microbial cellulose scaffold-PVP-hydroxyapatite with a variation of the concentration of Ca2+ and PO43- of 100:50 mM potential as a candidate for bone healing.
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