The target of the Covid-19 vaccination in Indonesia reached 181,554,465 people. Until August 25, 2021, the proportion of people who received the new COVID-19 vaccine was 12.11%, while in Southeast Sulawesi the number of people who had been vaccinated was 4,348 people (stage 1), then in Kendari City there were 3,061 people who had been vaccinated against stage 1 . The low percentage of vaccine receipts in the Kendari City community cannot be separated from the existence of influencing factors, one of which is due to the perception of the community itself. The purpose of this study was to analyze the acceptance of COVID-19 vaccination with the Health Belief Model theory approach in the community in Poasia District, Kendari City. This study used a cross sectional study with a sample of 110 respondents. The results of this study indicate that the variables related to the acceptance of the COVID-19 vaccine are education (p-value = 0.010), occupation (p-value = 0.006), knowledge (p-value = 0.000), safety perception (p-value = 0.000 ), vulnerability (p-value = 0.004), perceived benefits (p-value = 0.006) and perceived barriers (p-value = 0.000). While the unrelated are gender (p-value = 0.229) and age (p-value = 0.180). The results of the multivariate analysis showed that the related variables were knowledge (p-value = 0.004), perceived security (p-value = 0.006), perceived vulnerability (p-value = 0.020) and perceived barriers (p-value = 0.004)