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All Journal Jurnal Sehat Indonesia (JUSINDO) Surabaya Biomedical Journal
Alyaa Nabiila
Universitas Muhammadiyah Surabaya
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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SINDROMA NEFROTIK RELAPS DENGAN ANEMIA PADA ANAK Aty Firsiyanti; Alyaa Nabiila; Hava Ayu Millenia
Surabaya Biomedical Journal Vol. 3 No. 3 (2024): May
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v3i3.139

Abstract

Introduction: Nephrotic syndrome is a kidney disease characterized by edema, hypoalbumin, hyperlipidemia, and massive proteinuria. The prevalence in children ranges from 2-7 cases per 100,000 children under 18 years of age and most experience relapse. The prognosis for nephrotic syndrome in which it relapses will increase the risk of other complications. Case report: A 4-year-old boy was diagnosed with nephrotic syndrome characterized by anasarca edema, hypoalbumin, hypercholesterolemia, and massive proteinuria. The patient was included in the relapsed nephrotic syndrome category because he had previously been diagnosed with nephrotic syndrome and had experienced remission. Currently, the therapy that has been given consists of bed rest, fluid restriction, administration of the diuretic furosemide and administration of the oral steroid prednisone again. In addition, the patient experienced anemia due to complications from nephrotic syndrome and a PRC transfusion was planned. Discussion: Nephrotic syndrome is a kidney disease that often occurs in children. The prevalence is 15 times more common in children than adults. As many as 60-70% will experience a relapse. Relapsing nephrotic syndrome requires longer duration of corticosteroid therapy. Anemia is one of the complications in relapsing nephrotic syndrome.
Advanced-Stage Retinoblastoma with Systemic Manifestations Due to Delayed Diagnosis of Congenital Leukocoria: A Case Report Alyaa Nabiila; Faliqul Bahar Muhammad; Basuki Rokhmad
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 2 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i2.547

Abstract

Background: Retinoblastoma is the most common primary intraocular malignancy in children, with leukocoria as its hallmark clinical sign. Delayed diagnosis may lead to advanced disease, extraocular extension, and a poor prognosis. Case Presentation: A 2-year-4-month-old girl presented to the emergency department with recurrent vomiting, weakness, and decreased activity. Leukocoria of the left eye had been noted since birth but had never been medically evaluated. Ophthalmologic examination revealed no light perception, proptosis, leukocoria, a mid-dilated nonreactive pupil, and restricted extraocular movements in the left eye. B-scan ultrasonography demonstrated a solid intraocular mass suggestive of retinoblastoma. Computed tomography revealed a calcified intraorbital mass with irregular thickening of the left optic nerve and mild cerebral edema, raising suspicion of optic nerve invasion. The patient was classified as Group E retinoblastoma according to the International Intraocular Retinoblastoma Classification and as stage III according to the International Retinoblastoma Staging System. Discussion: This case highlights how nonspecific systemic manifestations may obscure the diagnosis of retinoblastoma and contribute to delayed recognition. Persistent leukocoria that remains unevaluated may progress to advanced disease with possible extraocular extension and a high risk of metastasis. Conclusion: Early recognition of leukocoria and routine red reflex screening are essential for preventing delayed diagnosis and disease progression in children with retinoblastoma.
Co-Authors Aty Firsiyanti Basuki Rokhmad Faliqul Bahar Muhammad Hava Ayu Millenia