This study aims to determine the factors that affect interest in entrepreneurship among the youth in the district on Wangon and to know the different types of business activities conducted by the public at large. Interest in entrepreneurship need to be cultivated and improved particularly among the youth as the future generation as an attempt to fill the independence activities. Based on the results of the discussion of multiple regression analysis that has been done in this study can be concluded that: It turns out the variables that affect entrepreneurship interest on the youth in the District Wangon is an environment variable because of the environment around the dwelling and social environment significantly affect interest in entrepreneurship. Then variable also affects the business opportunities in the entrepreneurship interest among the youth in the district Wangon, where the odds is an opportunity that should be utilized to try to do your own business with entrepreneurship by creating your own opportunities. And Variable confident, uplifting and educational level did not affectthe interest in entrepreneurship among the youth in the district Wangon, where people Wangon has included urban areas with already high levels of community education. It is expected to furtherresearch needs to consider other variables such as responsibility, gender or any other variable that does not exist in this study.Keywords: self-employment, interest, youth, environment, business opportunities