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Jamilah Abbas
Research Centre for Chemistry. Indonesian Institute of Sciences, PUSPIPTEK Area, Serpong, Tangerang 15314, Indonesia
Immunology & microbiology

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Anti-oxidant and anti-bacterial activities of 11 Calophyllum species from Indonesia Jamilah Abbas
Journal of Microbial Systematics and Biotechnology Vol 1, No 2 (2019): December 2019
Publisher : Microbiology Division, Research Center for Biology, Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (672.099 KB) | DOI: 10.37604/jmsb.v1i2.22

Abstract

Members of Calophyllum (Calophyllaceae) are commonly used as herbal medicine in Indonesia from the beginning of civilization. Due to their tremendous potential as a source for pharmaceutical industry, we selected 11 Calophyllum species for the current anti-oxidant and anti-bacterial studies, namely, Calophyllum euryphyllum, C. bicolor, C. flavoramulum, C incrassaptum, C. lowei, C. macrophyllum, C. nodosum, C. soulattri, C. tetrapterum, C. teysmannii, and C. tomentosum. The methods include Calophyllum stem bark extraction and separation into n-hexane, ethyl acetate, and butanol fractions, followed by the antioxidant analysis using DPPH (2,2-diphenyl-1-picrylhydrazyl radical scavenging) and the anti-bacterial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. The results showed that n-hexane fraction of C. soulattri exhibited the best anti-oxidant activity (IC50 = 2.2 µg/m). This study also showed that a xanthone compound isolated from C. macrophyllum, namely, 1,8 - dihydroxy-6 methoxy xanthone exhibited the anti-oxidant activity with IC50 = 1.56 ppm.
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