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All Journal ARTERI : Jurnal Ilmu Kesehatan JOURNAL OF Mother and Child Health Concerns
Muhammad Nur
Rumah Sakit Umum Daerah Pringsewu
Electrical & Electronics Engineering Health Professions Medicine & Pharmacology Nursing Public Health

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Derajat Toksisitas Hemoglobin Pada Penderita Kanker Kolorektal Yang Mendapat Kemoterapi CapeOX Yusmaidi; Jordy Oktobiannobel; Muhammad Nur; Bella Sabila Dananda
ARTERI : Jurnal Ilmu Kesehatan Vol 1 No 4 (2020): Agustus
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v1i4.86

Abstract

Advances in the treatment and use of chemotherapy have been shown to improve the life expectancy rate for colorectal cancer patients. Studies conducted in China and Hongkong have shown that CapeOX combination chemotherapy regimens are more commonly used than in Europe and the United States. However, the use of chemotherapy drugs containing oxaliplatin and capecitabine can cause side effects such as hematological toxicity, which is one of them is anemia. This study aims to determine the difference in the form of a decrease in the average levels of hemoglobin and the degree of hemoglobin toxicity in colorectal cancer patients undergoing CapeOX chemotherapy. The Design in this study is a historical (retrospective) cohort. This study sample was 70 colorectal cancer patients who received CapeOX chemotherapy for 6 cycles at RSUD Dr. H. Abdul Moeloek in 2018-2019. Consecutive sampling is used in the sampling method. The statistical analysis is using Paired T-Test. There is a significant difference in the average hemoglobin level of colorectal cancer patients (p-value = <0.005), which receive CapeOX chemotherapy for 6 cycles. Besides, there is an increase in the number of patients who get hemoglobin toxicity and the chemotherapy cycle. In the first cycle, 59 patients (84.3%) got hemoglobin toxicity after chemotherapy, and the number continued to increase to 69 patients (98.6%) in the sixth cycle. There was a decrease in hemoglobin levels in colorectal cancer patients who received CapeOX chemotherapy with p-value = <0.05 and increased patients who got hemoglobin toxicity.
Correlations of alanine and aspartate aminotransferase levels with high-sensitivity C-reactive protein in pediatric patients with beta-thalassemia major Wahyu Rahma Sari; Mulat Muliasih; Dita Fitriani; Muhammad Nur
THE JOURNAL OF Mother and Child Health  Concerns Vol. 5 No. 5 (2026): August 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mchc.v5i5.3916

Abstract

Background: Beta-thalassemia major is a hereditary blood disorder characterized by severe anemia requiring lifelong regular blood transfusions. Repeated transfusions may lead to iron overload, which can cause oxidative stress, hepatocellular injury, and chronic inflammation. Serum glutamic-pyruvic transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT) are commonly used to assess hepatocellular injury, whereas high-sensitivity C-reactive protein (hs-CRP) can detect low-grade systemic inflammation. Purpose: To determine the correlation between SGPT and SGOT levels and hs-CRP levels in pediatric patients with beta-thalassemia major. Method: This analytical observational study used a cross-sectional design and secondary data from medical records of pediatric patients with beta-thalassemia major treated at Pringsewu Regional General Hospital. Data were collected in February 2025 from records of patients treated between September and November 2024. A purposive sampling technique was used based on predetermined inclusion and exclusion criteria, resulting in 43 eligible patients. Data were analyzed using the Spearman correlation test with a significance level of p < 0.05. Results: The mean SGPT, SGOT, and hs-CRP levels were 58.86 ± 30.749 U/L, 55.67 ± 23.551 U/L, and 1.1216 ± 1.19167 mg/L, respectively. A significant positive correlation was found between SGPT and hs-CRP levels (p = 0.025; r = 0.341), indicating a weak positive correlation. A significant positive correlation was also found between SGOT and hs-CRP levels (p = 0.005; r = 0.421), indicating a moderate positive correlation. Conclusion: SGPT and SGOT levels were significantly and positively correlated with hs-CRP levels in pediatric patients with beta-thalassemia major. These findings suggest that hepatocellular injury and systemic inflammation may occur concurrently in patients with transfusion-dependent beta-thalassemia.
Co-Authors Bella Sabila Dananda Dita Fitriani Jordy Oktobiannobel Mulat Muliasih Wahyu Rahma Sari Yusmaidi