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Jing Jing Chang
Universiti Tunku Abdul Rahman

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Positive Interval Observer-based State Feedback Controller for Uncertain General Anaesthesia System Jing Jing Chang; S. Syafiie
Indonesian Journal of Electrical Engineering and Computer Science Vol 10, No 3: June 2018
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijeecs.v10.i3.pp1000-1006

Abstract

The drug delivery process of general anaesthesia in the human body is most commonly described by the Pharmacokinetic/Pharmacodynamic (PK/PD) model. Since the PK model is a positive linear system, the design of the controller can be treated as a positive stabilization problem. In this paper, a state feedback controller with positive interval observer was designed using a linear programming approach by taking into account the inter-individual variability among patient in the PK model. The designed controller was assessed by simulation on a pool of patients. The result shows that the design of a fix controller for the whole population is difficult due to the conflict between performance and robustness.
Co-Authors S. Syafiie