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All Journal Indonesian Journal of Rheumatology JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Grady Krisandi
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

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Analisis Potensi Nanopartikel Seng Oksida Sebagai Terapi Alternatif Terhadap Uropathogenic Escherichia coli Penyebab Infeksi Saluran Kemih Kelvin Kohar; Grady Krisandi; Stephanie Amabella Prayogo
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.278

Abstract

Background: To date, urinary tract infection (UTI) is still becoming the world’s major health problem that infected 150 million people annually. Uropathogenic Escherichia coli (UPEC) is the most common cause, accounted for more than 80% of total cases. UPEC infection mechanism is supported by many virulence factors owned that contribute in causing antibiotic resistance. Antibiotics are currently used as main pharmacologic therapy for UTI; therefore, treatment failures often occur. The advancement of nanoparticles technology reveals an antimicrobial activity in zinc oxide nanoparticles. Hence, this literature review is written to discuss the potential of zinc oxide nanoparticles as an alternative as well as to help reaching the third 2030 sustainable development goals.Methods: This article was written using the literature review method. We did literature searching by using some keywords in several databases. Inclusions and exclusions criteria were used. The final result yielded 30 studies related to the topic.Discussion: Zinc oxide nanoparticles can be synthesized from Aloe vera plant extraction. In small concentration, 0.3 µg/ml, nanoparticles show an antiadhesion effect by reducing flu and fimH gene expression as UPEC’s virulence factors. The effectivity and safety of nanoparticles in this concentration have also been proven in vitro. Furthermore, in high concentration, these nanoparticles can act as antibiofilm and antibacterial.Conclusion: Zinc oxide nanoparticle has a promising characteristic of antiadhesion, antibacterial and antibiofilm. The safety have also been proven in vitro and in vivo. Both results show a huge zinc oxide nanoparticles potential as an alternative treatment of UTI caused byUPEC. Keywords: Urinary tract infection, Zinc oxide nanoparticle, Uropathogenic Escherichia coli
Efficacy and Safety of Stem Cell Transplantation in Rheumatoid Arthritis: ASystematic Review of Trials Grady Krisandi
Indonesian Journal of Rheumatology Vol. 15 No. 1 (2023): IJR VOL 15 No 1
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/IJR.v15i1.241

Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune disorder thatdeteriorates the quality and function of the synovium membrane, resultingin chronic inflammation, pain, and progressive joint destruction. Based onprevious clinical research, stem cell transplantation has shown a promisingtherapeutic effect for RA based on its anti-inflammatory,  immunomodulatory, and regenerative properties. This systematic reviewaims to evaluate the efficacy and safety of stem cell transplantation forrheumatoid arthritis therapy. Methods: A literature search was performedvia PubMed, ProQuest, EBSCOHost, EMBASE, SCOPUS, Cochrane, DOAJ,and clinicaltrial.gov databases, selecting studies that evaluated the effect ofstem cells on rheumatoid arthritis from inception to April 7, 2023. TheCochrane Risk of Bias was used to assess randomized controlled trials andROBINS-I was used to assess clinical trials. Results: 7 randomizedcontrolled trials (RCTs) and 12 non-randomized studies involving 682subjects were included in this review. Stem cell transplantation was relatedwith better outcomes based on significant improvement of the DAS28 score, HAQ score, ACR score, and laboratory parameters. There were no significant changes in safety parameters compared to the baseline value and control group. Fever, flu-like symptoms, nausea, and vomiting were the most frequently reported adverse effects. Nevertheless, this review revealed a moderate risk of bias and high heterogeneity of the efficacy outcomes of RCTs. Conclusion: Stem cell-based therapies provide clinical benefits for rheumatoid arthritis patients with satisfactory safety measures.  
Co-Authors Aditya Parawangsa Kelvin Kohar Kelvin Kohar Stephanie Amabella Prayogo