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All Journal Program Kreativitas Mahasiswa - Penelitian Jurnal Luka Indonesia
Dwi Astika Sari
Program Studi Ilmu Keperawatan, Fakultas Kedokteran, Universitas Brawijaya
Health Professions Medicine & Pharmacology Nursing Public Health

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EKSTRAK CACING TANAH SEBAGAI INOVASI PENYEMBUHAN ULKUS DIABETIK BERBASIS INDUKSI DENSITAS AKSON Mardiati, Ni Putu Jeny; Yunitasari, Arinda Nur; Sari, Dwi Astika; Saraswasta, I Wayan Gede; Putra, Fetreo Negeo; Kristianto, Heri
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Reduction of nerve growth factor expression in diabetic ulcer affects overall wound healing. Earthworm (Pheretima aspergillum) can stimulate schwann cell proliferation and migration to support axonal elongation. The objective of this study is to compare wound healing functions in diabetic ulcer of rats using earthworm extract, hydrogel, and conventional dressing. This study applied a true-experimental posttest only controlled group design. 21 days after treatment, the group receiving earthworm extract had a significantly higher percentage of wound contraction and axonal density compared to the control group (p<0.05). These results show that earthworm extract can promote wound healing in diabetic ulcer. Keywords: Diabetic Ulcer, Earthworm (Pheretima aspergillum), Wound Contraction, Peripheral Nerve Regeneration.
THE EFFECT OF PHERETIMA ASPERGILLUM EXTRACT ON THE INCREASE OF HAIR FOLLICLES NUMBER IN DIABETIC ULCER GRADE II IN WISTAR RAT Kristianto, Heri; Sari, Dwi Astika
in process
Publisher : ETN Centre Indonesia

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Abstract

Background: Diabetic ulcer is the result of serious microvascular complication of diabetes mellitus that is caused by vascular insufficiency, resulting in dry skin, loss of taste, and a decrease in the number of hair follicles. Earthworm (Pheretima aspergillum) has a bioactive component of IGF-1 (insulin like growth factor 1), which can stimulate cell growth and survival. IGF-1 is involved in hair follicle growth by regulating cell proliferation and migration through the cellular mechanism of its receptor (IGF - 1R). This study aimed to determine the effect of earthworm extract on the increase of hair follicles number in rats induced diabetic ulcer stage II. Methods: This study used a true experimental posttest only controlled group design. Samples were randomly selected, divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. Ulcer treatment is done for 21 days, on day 22, rats were euthanized. The numbers of hair follicles in skin tissue connecting to nervous fibers were identified using silver impregnation stain. Results: The results showed that the treatment groups that received earthworm extract had significantly higher number of hair follicles as compared to the control groups (p=0.000). The administration of earthworm extract via topical has an optimal effect on the increase of hair follicles numbers. Conclusion: It can be concluded that the extract of earthworm (Pheretima aspergillum) can increase the growth of hair follicles in rats diabetic models. Keywords: diabetic ulcer, earthworm (Pheretima aspergillum), hair follicles.
THE EFFECT OF PHERETIMA ASPERGILLUM EXTRACT ON THE INCREASE OF HAIR FOLLICLES NUMBER IN DIABETIC ULCER GRADE II IN WISTAR RAT Kristianto, Heri; Sari, Dwi Astika
Jurnal Luka Indonesia Vol 2 No 2 Juni 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.23

Abstract

Background: Diabetic ulcer is the result of serious microvascular complication of diabetes mellitus that is caused by vascular insufficiency, resulting in dry skin, loss of taste, and a decrease in the number of hair follicles. Earthworm (Pheretima aspergillum) has a bioactive component of IGF-1 (insulin like growth factor 1), which can stimulate cell growth and survival. IGF-1 is involved in hair follicle growth by regulating cell proliferation and migration through the cellular mechanism of its receptor (IGF - 1R). This study aimed to determine the effect of earthworm extract on the increase of hair follicles number in rats induced diabetic ulcer stage II. Methods: This study used a true experimental posttest only controlled group design. Samples were randomly selected, divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. Ulcer treatment is done for 21 days, on day 22, rats were euthanized. The numbers of hair follicles in skin tissue connecting to nervous fibers were identified using silver impregnation stain. Results: The results showed that the treatment groups that received earthworm extract had significantly higher number of hair follicles as compared to the control groups (p=0.000). The administration of earthworm extract via topical has an optimal effect on the increase of hair follicles numbers. Conclusion: It can be concluded that the extract of earthworm (Pheretima aspergillum) can increase the growth of hair follicles in rats diabetic models. Keywords: diabetic ulcer, earthworm (Pheretima aspergillum), hair follicles.
THE EFFECT OF PHERETIMA ASPERGILLUM EXTRACT ON THE INCREASE OF HAIR FOLLICLES NUMBER IN DIABETIC ULCER GRADE II IN WISTAR RAT Kristianto, Heri; Sari, Dwi Astika
Jurnal Luka Indonesia Vol 2 No 2 Juni 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.23

Abstract

Background: Diabetic ulcer is the result of serious microvascular complication of diabetes mellitus that is caused by vascular insufficiency, resulting in dry skin, loss of taste, and a decrease in the number of hair follicles. Earthworm (Pheretima aspergillum) has a bioactive component of IGF-1 (insulin like growth factor 1), which can stimulate cell growth and survival. IGF-1 is involved in hair follicle growth by regulating cell proliferation and migration through the cellular mechanism of its receptor (IGF - 1R). This study aimed to determine the effect of earthworm extract on the increase of hair follicles number in rats induced diabetic ulcer stage II. Methods: This study used a true experimental posttest only controlled group design. Samples were randomly selected, divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. Ulcer treatment is done for 21 days, on day 22, rats were euthanized. The numbers of hair follicles in skin tissue connecting to nervous fibers were identified using silver impregnation stain. Results: The results showed that the treatment groups that received earthworm extract had significantly higher number of hair follicles as compared to the control groups (p=0.000). The administration of earthworm extract via topical has an optimal effect on the increase of hair follicles numbers. Conclusion: It can be concluded that the extract of earthworm (Pheretima aspergillum) can increase the growth of hair follicles in rats diabetic models. Keywords: diabetic ulcer, earthworm (Pheretima aspergillum), hair follicles.
Co-Authors Arinda Nur Yunitasari Fetreo Negeo Putra Heri Kristianto I Wayan Gede Saraswasta Ni Putu Jeny Mardiati