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All Journal Matematika dan Sains Biogenesis: Jurnal Ilmiah Biologi Jurnal Kefarmasian Indonesia
Mulyati Sarto
Laboratorium Fisiologi Hewan, Fakultas Biologi, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Mathematics Medicine & Pharmacology

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OPTIMASI DOSIS ALOKSAN UNTUK INDUKSI DIABETES MENGGUNAKAN HEWAN MODEL TIKUS PUTIH BETINA Nur Qomariyah 1, ; Mulyati Sarto2,
Matematika dan Sains Vol 18, No 2 (2011)
Publisher : Matematika dan Sains

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Alloxan was one diabetogen often used to study diabetes either with single or repeated doses. Single dose used for induction of diabetic rats ranged 100-180 mg/kgbw, but the results are often not satisfied or not maximum, the success rate, mortality, and duration of diabetic conditions in experimental animals. The purpose of this study to determine the dose of alloxan for induction of diabetic which lasted more than 3 weeks. The research was done with complete randomized design using female white rats, Wistar strain, age 4 months, weight 170-200 grams for 20 days. Thirty-five rats were divided into seven groups, were 5 of each. All test animals induced with aloksan monohydrate in a dose respectively 100, 110, 120, 130, 140, 150, and 160 mg/kgbw intraperitonially. The results were analyzed ANAVA and LSD (p <0.05). The results for 20 days showed dose alloxan of 100 and 110 mg / kgbw could not produce a diabetic condition, dose of 120 mg/ kgbw can induce diabetic but did not survive more than 7 days, the dose can induce diabetic 130mg/kgbw which last up to 20 days. Doses of 140, 150, and 160mg/kgBB can induce diabetic, but have high mortality rate of between 60-80%. Therefore, dose of alloxan 130 mg/kgbw most effective for the induction of diabetic and last up to 20 days and potentially more than 20 days.
Profil Hematologi Tikus (Rattus norvegicus Berkenhout, 1769) Galur Wistar Jantan dan Betina Umur 4, 6, dan 8 Minggu Fitria, Laksmindra; Sarto, Mulyati
Biogenesis Vol 2, No 2 (2014)
Publisher : Jurusan Biologi UIN Alauddin Makassar

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Animal model is very important in biomedical research. Prior to apply in human or other primates, experiments using lower animals model such as rodents must be conducted (preclicical studies). Wistar rats (Rattus norveg
Pengaruh Pemberian Fraksi Protein Ekstrak Kuda Laut (Hippocampus kuda Bleeker, 1852) terhadap Peningkatan Kadar Hemoglobin Mencit (Mus musculus L) Adam, Kindi; Fitria, Laksmindra; Sarto, Mulyati
Jurnal Kefarmasian Indonesia VOLUME 4, NOMOR 2, AGUSTUS 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Seahorse (Hippocampus kuda) is known to have a high concentration of iron, taurin and progesteron as testosteron precursor. Seahorse extract can increase the production of testosterone hormone of mice. On the erythrocytes development, kidney is stimulated to release erythropoietin hormone in case of hypoxia and also related with testosterone production. Erythropoietin control erythrocytes development and increase hemoglobin synthesis. The objective of experiment was to study the effect of seahorse extract as supplemented food in optimal concentration in range of 100, 200 and 300 mg/kg body weight on mice’s hematopoiesis and erythropoiesis. Each of treatment groups consist of 5 mices. The observed parameters were hematocrit value, hemoglobin concentration and renal index which observed on day 0, 34 and 67. The result showed that treatment of seahorse protein fraction extract until 300 mg/kg body weight dosage have no effect to the hematocrit value. The 200 mg/kg body weight extract dosage was able to increase the hemoglobin rate measurement. Renal index of Mice on day 34 and 67 after treatment did not give significant difference among treatment and control
Co-Authors Kindi Adam Laksmindra Fitria N. Qomariyah