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Rosita Melannisa, Rosita
Faculty of Pharmacy, Universitas Muhammadiyah Surakarta
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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DAYA ANTIBAKTERI EKSTRAK ETANOL DAUN SENGGANI (Melastoma affine D. Don) Kusumowati, Ika Trisharyanti Dian; Melannisa, Rosita; Prasetyawan, Angga
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Melastoma affine D. Don had some activities such as anthelmintic, antibacteria, antiinfiammation, antifungal, and antitumor. The aims of this research was determine antibacteria activity of ethanolic extract of Melastoma affine D. Don. The antimicrobial activity was tested by solid dilution method to get Minimum Inhibition Concentration (MIC). The compounds in Melastoma affine D. Don was analyzed by tube test method and Thin Layer Chromatography (TLC) with chloroform : methanol : formic acid (8,5:1,5:0,5) as mobile phase and silica gel GF254 as stationary phase. The result showed ethanolic extract of Melastoma affine D. Don contains alkaloid, polyphenol, fiavonoid, saponin, and essential oil. The MIC of Senggani against Staphylococcus aureus was 2% and 3% against Escherichia coli and the extract could not inhibit Staphylococcus aureus and Escherichia coli multiresistant until concentration 7% extract ethanol.Keywords: Melastoma affine D. Don, Staphylococcus aureus, Escherichia coli
KORELASI KANDUNGAN FENOLIK DAN AKTIVITAS ANTIOKSIDAN DAUN JAMBU METE Kusumowati, Ika Trisharyanti Dian; Melannisa, Rosita; Ratri, Kartikaning
Biomedika Vol 3, No 2 (2011): Biomedika Agustus 2011
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

The ethanolic extract of Anacardium occidentale L. leaves contains phenolic compounds,  avonoids, alkaloids, saponins, tannins, and steroids that could have antioxidant activity. The aim of this research was to determine the correlation between the antioxidant activity and the phenolic compounds of the ethanol extract of Anacardium occidentale L. leaf. The DPPH methode was used to determine the antioxidant activity. The total phenolic determined using Folin-Ciocalteu reagent. There was a positive correlation between antioxidant activity and total phenolic content in the ethanolic extract of cashew leaf with correlation coef cient R2 = 0.5888.Keywords: Anacardium occidentale L., antioxidant, phenolic compounds
UJI AKTIVITAS ANTIRADIKAL EKSTRAK ETANOL DAUN Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, dan Gynura procumbens Merr. DENGAN METODE DPPH (1,1- Difenil-2- Pikril Hidrazil) SERTA PENETAPAN KADAR FENOLIK TOT Ratnaningrum, Astrina Dewi; Wahyuni, Arifah Sri; Melannisa, Rosita; Dian Kusuma, Ika Trisharyanti
Pharmacon Vol 13, No 2 (2012)
Publisher : Pharmacon

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Abstract

Daun  Elephantopus schaber L. (tapak liman), Ocimum basilicum L.forma citratum Back., (selasih) Graptophylum pictum Griff (daun ungu), dan Gynura procumbens Merr. (sambung nyawa) memiliki kandungan kimia yang dapat berperan sebagai antiradikal, diantaranya adalah senyawa fenolik. Penelitian ini dilakukan untuk melihat korelasi kandungan fenolik total keempat daun terhadap aktivitas antiradikalnya. Sampel uji yaitu ekstrak etanol daun selasih, ungu, sambung nyawa, dan tapak liman ditentukan aktivitas antiradikal dengan menggunakan metode DPPH (1,1 difenil-2-pikrilhidrazil) kemudian dihitung nilai inhibitory concentration (IC50). Kandungan fenolik total ditentukan secara spektrofotometri menggunakan pereaksi Folin-Ciocalteu dan dihitung sebagai GAE (gallic acid equivalent) yaitu jumlah kesetaraan miligram asam galat dalam satu gram sampel. Penelitian menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman memiliki aktivitas antiradikal dengan nilai IC50 berturut-turut 36,028; 54,998; 103,650; 252,857µg/mL dan kadar fenolik total berturut-turut 167,451; 147,064; 39,371 dan 20,539 mg/g sampel. Hasil penelitian secara keseluruhan menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman berkorelasi positif terhadap aktivitas antiradikalnya.  Kata kunci: Antiradikal, DPPH, IC50, fenolik total, Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, Gynura procumbens Merr.
UJI AKTIVITAS ANTIRADIKAL EKSTRAK ETANOL DAUN Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, dan Gynura procumbens Merr. DENGAN METODE DPPH (1,1- Difenil-2- Pikril Hidrazil) SERTA PENETAPAN KADAR FENOLIK TOT Ratnaningrum, Astrina Dewi; Wahyuni, Arifah Sri; Melannisa, Rosita; Dian Kusuma, Ika Trisharyanti
Pharmacon: Jurnal Farmasi Indonesia Vol 13, No 2 (2012)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (28.664 KB)

Abstract

Daun  Elephantopus schaber L. (tapak liman), Ocimum basilicum L.forma citratum Back., (selasih) Graptophylum pictum Griff (daun ungu), dan Gynura procumbens Merr. (sambung nyawa) memiliki kandungan kimia yang dapat berperan sebagai antiradikal, diantaranya adalah senyawa fenolik. Penelitian ini dilakukan untuk melihat korelasi kandungan fenolik total keempat daun terhadap aktivitas antiradikalnya. Sampel uji yaitu ekstrak etanol daun selasih, ungu, sambung nyawa, dan tapak liman ditentukan aktivitas antiradikal dengan menggunakan metode DPPH (1,1 difenil-2-pikrilhidrazil) kemudian dihitung nilai inhibitory concentration (IC50). Kandungan fenolik total ditentukan secara spektrofotometri menggunakan pereaksi Folin-Ciocalteu dan dihitung sebagai GAE (gallic acid equivalent) yaitu jumlah kesetaraan miligram asam galat dalam satu gram sampel. Penelitian menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman memiliki aktivitas antiradikal dengan nilai IC50 berturut-turut 36,028; 54,998; 103,650; 252,857µg/mL dan kadar fenolik total berturut-turut 167,451; 147,064; 39,371 dan 20,539 mg/g sampel. Hasil penelitian secara keseluruhan menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman berkorelasi positif terhadap aktivitas antiradikalnya.  Kata kunci: Antiradikal, DPPH, IC50, fenolik total, Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, Gynura procumbens Merr.
KORELASI KANDUNGAN FENOLIK DAN AKTIVITAS ANTIOKSIDAN DAUN JAMBU METE Kusumowati, Ika Trisharyanti Dian; Melannisa, Rosita; Ratri, Kartikaning
Biomedika Vol 3, No 2 (2011): Biomedika Agustus 2011
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v3i2.251

Abstract

The ethanolic extract of Anacardium occidentale L. leaves contains phenolic compounds, ? avonoids, alkaloids, saponins, tannins, and steroids that could have antioxidant activity. The aim of this research was to determine the correlation between the antioxidant activity and the phenolic compounds of the ethanol extract of Anacardium occidentale L. leaf. The DPPH methode was used to determine the antioxidant activity. The total phenolic determined using Folin-Ciocalteu reagent. There was a positive correlation between antioxidant activity and total phenolic content in the ethanolic extract of cashew leaf with correlation coef? cient R2 = 0.5888.Keywords: Anacardium occidentale L., antioxidant, phenolic compounds
DAYA ANTIBAKTERI EKSTRAK ETANOL DAUN SENGGANI (Melastoma affine D. Don) Kusumowati, Ika Trisharyanti Dian; Melannisa, Rosita; Prasetyawan, Angga
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i2.278

Abstract

Melastoma affine D. Don had some activities such as anthelmintic, antibacteria, antiinfiammation, antifungal, and antitumor. The aims of this research was determine antibacteria activity of ethanolic extract of Melastoma affine D. Don. The antimicrobial activity was tested by solid dilution method to get Minimum Inhibition Concentration (MIC). The compounds in Melastoma affine D. Don was analyzed by tube test method and Thin Layer Chromatography (TLC) with chloroform : methanol : formic acid (8,5:1,5:0,5) as mobile phase and silica gel GF254 as stationary phase. The result showed ethanolic extract of Melastoma affine D. Don contains alkaloid, polyphenol, fiavonoid, saponin, and essential oil. The MIC of Senggani against Staphylococcus aureus was 2% and 3% against Escherichia coli and the extract could not inhibit Staphylococcus aureus and Escherichia coli multiresistant until concentration 7% extract ethanol.Keywords: Melastoma affine D. Don, Staphylococcus aureus, Escherichia coli
Co-Authors Angga Prasetyawan, Angga Arifah Sri Wahyuni Astrina Dewi Ratnaningrum, Astrina Dewi Ika Trisharyanti Dian Kusumowati Kartikaning Ratri, Kartikaning