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A. Karim Zulkarnain, A. Karim
Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
Health Professions Medicine & Pharmacology Public Health

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STABILITAS FISIK DAN AKTIVITAS KRIM W/O EKSTRAK ETANOLIK BUAH MAHKOTA DEWA (Phaleria macrocarph (scheff.) Boerl,) SEBAGAI TABIR SURYA Sofyana, Hidayatu Hana; Zulkarnain, A. Karim
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (872.764 KB) | DOI: 10.14499/mot-TradMedJ18iss2pp%p

Abstract

Krim ekstrak etanolik buah mahkota dewa (Phaleria macrocarph (scheff.) Boerl,) telah diuji aktivitasnya sebagai tabir surya secara in vivo. Penelitian ini bertujuan untuk mengetahui aktivitas tabir surya dan stabilitas fisiknya. Penentuan aktivitas tabir surya dilakukan dengan menentukan nilai SPF (Sun Protection Factor) secara ini vivo pada mencit galur Swiss Weber. Uji ini digunakan 1 kelompok tanpa perlakuan, 1 kelompok control negatif (basis), dan 4 kelompok perlakuan. Kelompok perlakuan adalah krim w/o ekstrak etanolik buah mahkota dewa. Nilai SPF merupakan perbandingan DEM pada kulit yang diberi krim tabir surya dengan DEM pada kulit tanpa krim. Uji stabilitas fisik krim meliputi uji viskositas, daya sebar, daya lekat, dan rasio pemisahan. Data dianalisis menggunakan SPSS untuk mengetahuipengaruh penambahan ekstrak dan lama penyimpanan terhadap kestabilan krim. Hasil penelitian menunjukkan bahwa krim mahkota dewa kadar 4,6,d dan 10% memiliki aktivitas sebagai tabir surya dengan nilai SPF sebesar 1,25; 1,56; 2,4; dan 3,05. Selain itu mahkota dewa memiliki stabilitas fisik yang baik selama penyimpanan.
AKTIVITAS AMILUM BENGKUANG (Pachyrrizus erosus (L.) Urban) SEBAGAI TABIR SURYA PADA MENCIT DAN PENGARUH KENAIKAN KADARNYA TERHADAP VISKOSITAS SEDIAAN Zulkarnain, A. Karim; Ernawati, Novi; Sukardani, Nurul Ikka
Majalah Obat Tradisional Vol 18, No 1 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.182 KB) | DOI: 10.14499/mot-TradMedJ18iss1pp%p

Abstract

Yam starch (Pachyrhizus erosus (L.) Urb.) with microparticles of size and had opaque properties could be used as an physical sunscreens. Yam starch was made in creams and lotions formulation and applied topically. This study aimed to determine the effect of yam starch concentration to the increasing of creams and lotions formulation as well as sunscreens activity in mice seen from its Sun Protecting Factor (SPF). Yam starch was obtained by the deposition method, then was done characterization and measurement of particle diameter. The formulation of creams and lotions each in 3 formulas with yam starch concentration of 15%, 20%, and 25%, further the viscosity and physical stability were observed under extreme heat and cold conditions. The observations during storage were colour, odor, homogenity, and viscosity. Sunscreen activity was determined by in vivo method using Swiss Webster female mice strains induced by 8-MOP, and then observation of its SPF value. The viscosity data  in extreme hot and cold conditions was analyzed statistically at significance level of 95%. The results showed that the more increase of  the concentration of yam starch the more  increase of viscosity, while the colour, odor, and homogenity of the formulation did not change during storage. Creams and lotions formulation with starch concentration of 15%, 20%, and 25%, had sunscreen activity in vivo in mice, with SPF value of 1.22; 1.52, and 2.38.
Co-Authors Hidayatu Hana Sofyana, Hidayatu Hana Novi Ernawati, Novi Nurul Ikka Sukardani, Nurul Ikka