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All Journal Indonesian Journal of Biotechnology Balobe: Jurnal Pengabdian Masyarakat
Gino Valentino Limmon, Gino Valentino
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Social Sciences Other

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Comparative Analysis of Genes Induced by Respiratory Syncytial Virus and DsRNA in Human Epithelial Cells Limmon, Gino Valentino
Indonesian Journal of Biotechnology Vol 18, No 2 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (479.473 KB)

Abstract

Epithelial cells are the primary target of respiratory viral infections and play a pivotal role in virusinducedlung infl ammation and in anti viral immune response. A common signal for the presence of viralinfections and induction of infl ammation is recognition of double stranded RNA (dsRNA). Thus far, therehas not been a high-throughput transcrptome analysis of RSV- or dsRNA-induced genes in primary humanbronchial epithelial cells (PHBE), nor there has been a comparison between dsRNA- and RSV-inducedgenes. To establish the transcriptome profi les and to determine the contribution of dsRNA in the inductionof infl ammation during respiratory virus infection, we compared the gene expression profi les of PHBE cellsthat were infected with Respiratory Syncytial Virus (RSV) or were treated with dsRNA. Our transcriptomeanalysis showed that RSV infection and and dsRNA treatment induced up-regulation of 2024 and 159 genesin PHBE respectively. Comparison of genes revealed that RSV and dsRNA commonly induced 75 genes inPHBE cells. The common up-regulated genes were functionally grouped in multiple response pathwaysinvolved in infl ammation and immune responses. Interestingly, there were several previously unreportedgenes that were up-regulated in primary human epithelial cells that are relevant to a TH2 allergic phenotype.This comparison of a high-throughput gene expression study offers a comprehensive view of transcriptionalchanges induced by dsRNA and RSV, and importantly compares dsRNA-induced genes with RSV-inducedgenes in PHBE cells.Keywords: RSV, dsRNA, transcriptome, immune response, infl ammation
EDUKASI LITERASI LINGKUNGAN SEBAGAI UPAYA RESTORASI TERUMBU KARANG BAGI SISWA SMA NEGERI 15 AMBON PULAU AMBON Haumahu, Sara; Rijoly, Fredrik; Supusepa, Junita; Limmon, Gino Valentino; Fakaubun, Fahrul Rozy
Balobe: Jurnal Pengabdian Masyarakat Vol 3 No 1 (2024): Balobe: Jurnal Pengabdian Masyarakat
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/balobe.3.1.36-44

Abstract

Indonesia memiliki ekosistem terumbu karang terluas di dunia. Ekosistem terumbu karang di Indonesia sangat rentan mengalami kerusakan baik sebagai akibat dari aktivitas antropogenik maupun pengaruh faktor fisik kimia perairan. Untuk mengatasi kerusakan ekosistem terumbu karang, salah satu upaya yang dilakukan adalah restorasi terumbu karang tersebut. Melihat bahwa terjadi penurunan keragaman sumber daya perikanan pada ekosistem terumbu karang serta kerusakan ekosistem tersebut, maka pemahaman tentang restorasi habitat terumbu karang merupakan hal yang sangat diperlukan. Kegiatan penyuluhan ini bertujuan untuk meningkatkan pemahaman siswa tentang upaya mencegah kerusakan terumbu karang dengan jalan restorasi terumbu karang. Kegiatan penyuluhan ini dilakukan pada siswa SMA Negeri 15, Pulau Ambon dengan menggunakan metode ceramah dan diskusi. Mekanisme kegiatan dibagi atas dua tahapan yaitu penyampaian materi oleh Tim Pelaksana PkM dari Jurusan Ilmu Kelautan Fakultas Perikanan dan Ilmu Kelautan Universitas Pattimura dan diskusi. Hasil kegiatan menunjukkan bahwa siswa memahami dengan baik materi yang diberikan meliputi definisi karang, funsgi dan manfaat terumbu karang, faktor penyebab kerusakan terumbu karang, metode transplantasi terumbu karang.Hal ini terlihat dari siswa yang berperan aktif dan antusias dengan menyampaikan barbagai pertanyaan selama kegiatan dilakukan.
Co-Authors Fahrul Rozy Fakaubun Junita Supusepa Rijoly, Fredrik Sara Haumahu