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All Journal Jurnal Kedokteran Hewan Malacca Pharmaceutics Journal of Bioresources and Environmental Sciences
Claus Jacob, Claus
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Environmental Science Immunology & microbiology Medicine & Pharmacology Veterinary

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Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia Khairan, Khairan; Arini, Musfira; Idroes, Rinaldi; Awang, Khalijah; Jacob, Claus
Malacca Pharmaceutics Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i1.29

Abstract

The dragon’s blood resin (Daemonorops draco wild Blume) has been used in folk medicine for pharmacological activities such as antimicrobial, antivirus, anti-inflammation, gastrointestinal disorders, blood circulation dysfunctions, antitumor, and cancer. This study was designated to evaluate the antibacterial activity of n-Hexane dragon’s blood resin extract against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231. The other purpose of this study was to determine the secondary metabolites compound of n-Hexane dragon’s blood resin extract. The antimicrobial activities of the n-Hexane dragon’s blood resin extract was determined using well diffusion method and the results showed that the extract at concentration of 15% exhibited antimicrobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231 with the diameter inhibition of 13.20 mm; 21.3 mm; and 13.0 mm respectively. The phytochemicals screening showed that the extract contains secondary metabolites in the form of flavonoids. The GC-MS analysis showed that n-Hexane dragon’s blood resin extract contains 48 chemicals compounds, and the compound at RT 26 was indicated a Drachorhodin compound (C17H 18O3) with the mass ration of m/z was 270 g/mol. Overall, the n-Hexane dragon’s blood resin extract be a good choice for antimicrobial agent against bacteria and fungi.
Bead milling liberates the antioxidant properties of nanosized tubers of Vernonia guineensis Benth (Asteraceae) Eya'ane Meva, Francois; Djomaha, Ludrice Dorence Yossa; Nasim, Muhammad Jawad; Ntoumba, Agnes Antoinette; Kouemegne, Armelle Michelle Houatchaing; Ottou, Patrice Brice Mvogo; Loe, Gisele Etame; Dibong, Siegfried Didier; Jacob, Claus
Journal of Bioresources and Environmental Sciences Vol 3, No 1 (2024): April 2024
Publisher : BIORE Scientia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61435/jbes.2024.19919

Abstract

Vernonia guineensis Benth. (Asteraceae), locally known as ‘African ginseng’, is an herbaceous plant with various therapeutic properties, sold by herbalists, and used in several traditional African preparations. Nanosizing has the capability to potentiate those preparations in their pharmacological properties. Premilling and extensive grinding using a planetary ball mill were used to reduce the size of V. guineensis tubers towards antioxidant studies. Water was used as an environmental friendly, cost effective solvent and dispersant to generate a nanocolloidal suspension of V. guineensis tubers. Size and size distribution were determined via photon correlation spectroscopy at room temperature which allows discussion on stability by Zeta potential and polydispersity index. Phytochemical screening shows presence of alkaloids, coumarins, polyphenol, saponins, tanins, terpenes, and anthraquinones. The distribution curve in water shows a polydispersed system with large hydrodynamic particles of size close to 1000 nm and a Z-average of 484.5 nm. The preparation separate in two phases with polydispersity index 0.217 for the supernatant and 0.543 for the suspension. In the supernatant and suspension, the particles zeta potential were -12.3 mV and -13.7mV respectively. The Mastersizer analysis indicates that there are smaller particles in volume in the supernatant than in the suspension. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity shows an increase in antioxidant activity, compared to that of ascorbic acid, in the nanoformulated state. These findings allow us to conclude on the potential of size reduction when compared to solvent extraction in pharmacologic preparations.
EFEK SITOTOKSIK HAARLEM OIL TERHADAP HL-60 CELL LINE DAN Steinernema feltiae (Cytotoxic Effect of Haarlem Oil on HL-60 Cell Line and Steinernema feltiae) Bahi, Muhammad; Jacob, Claus; Khairan, Khairan
Jurnal Kedokteran Hewan Vol 10, No 2 (2016): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v10i2.5038

Abstract

The objective of this research was to investigate cytotoxicity effect of Haarlem oil (HO) on HL-60 cell line and Steinernema feltiae (S. feltiae). The test results using trypan blue method and CellTiter-Glo assays revealed that HO showed higher cytotoxicity effect against HL-60 cell line especially at concentration of 1:10 and 1:5. Meanwhile, the MTT (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay revealed that the higher cytotoxicity effect showed at 1:5, with the cell viabilities were around 40-65%. The nematicidal assay discovered that HO at concentration of 1:5 showed higher activities compare to other concentrations with percentage viability of 70%. These studies have shown that HO shows cytotoxic effect against HL-60 cell lines, and moderate activity against S. feltiae as well.
AKTIVITAS BEBERAPA SENYAWA TURUNAN BENZOPIRAN (CHROMONES) DAN BENZOFURANON (COUMARANONES) TERHADAP Steinernema feltiae (The Activities of Benzopyran (Chromones) and Benzofuranones (Coumaranones) Derivatives against Steinernema feltiae) Khairan, Khairan; Bahi, Muhammad; Jacob, Claus; Idroes, Rinaldi
Jurnal Kedokteran Hewan Vol 10, No 1 (2016): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v10i1.3368

Abstract

This study was purposed to inquire the activities of benzopyran (chromones) and benzofuranones (coumaranones) derivatives against Steinernema feltiae (S. feltiae). The toxicity assay against S. feltiae showed that benzopyran derivatives 2, 3, 4, 6, and 9 have the highest activity on S. feltiae with viabilities percentage of 50%. The compound 9 demostrated the highest activity with LD 50 and LD values, 7.2 and 52.2 M, respectively. The activities of compound 7 and 10 showed the lowest toxicity. Interestingly, the activity of benzofuranone derivatives showed significant activities against S. feltiae. Compare to benzopyran derivatives, the benzofuranone derivatives has the highest toxicity, in particular compound 13 with LD 5.45 M. The nematicidal assay showed that benzofuranones (coumaranones) derivatives revealed higher activities than benzopyran (chromones) derivatives.Key words: chromones, benzopyran, coumaranones, benzofuranone, and Steinernema feltiae
AKTIVITAS SULFUR DAN SELENIUM NANOPARTIKEL TERHADAP CACING Steinerma feltiae DAN PERBANDINGAN TOKSISITASNYA TERHADAP SEL NEUROBLASTOMA (NEURO 2A CELL LINES) Khairan, Khairan; Idroes, Rinaldi; Bahi, Muhammad; Schaefer, Karl Herbert; Schneider, Thomas; Jacob, Claus
Jurnal Kedokteran Hewan Vol 9, No 1 (2015): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v9i1.2798

Abstract

Penelitian ini bertujuan mengetahui aktivitas sulfur dan selenium nanopartikel terhadap cacing Steinernema feltiae (S. feltiae) dan perbandingan toksisitasnya terhadap sel neuroblastoma (neuro 2A). Sulfur dan selenium nanopartikel aqueous nanoparticles dikarakterisasimenggunakan Nano Zetasizer pada pH 7 dan suhu 25 C. Dalam penelitian ini uji nematoda dilakukan terhadap S. feltiae. Hasil penelitian menunjukkan bahwa sulfur nanopartikel mempunyai aktivitas yang sangat tinggi terhadap S. feltiae dengan lethal dose 50 (LD50) berkisar pada 6,99 g/ml setelah 24 jam inkubasi. Sementara itu, live and dead assay dilakukan terhadap neuroblastoma sel (Neuro 2A cell lines). Hasil penelitian menujukkan bahwa aqueous sulfur nanopartikel (NPS) menunjukkan aktivitas yang lebih baik dibandingkan dengan aqueous selenium nanopartikel (NPSe) terhadap sel neuroblastoma (neuro 2A cell lines) dengan IC50 1 g/ml.
Co-Authors Arini, Musfira Dibong, Siegfried Didier Djomaha, Ludrice Dorence Yossa Eya'ane Meva, Francois Karl Herbert Schaefer, Karl Herbert Khairan Khairan Khalijah Awang Kouemegne, Armelle Michelle Houatchaing Loe, Gisele Etame Muhammad Bahi Nasim, Muhammad Jawad Ntoumba, Agnes Antoinette Ottou, Patrice Brice Mvogo Rinaldi Idroes Thomas Schneider, Thomas