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All Journal Asian Journal of Health Research
Ayu Rizky Widowati
Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Effect of Isoflavone in Cowpea (Vigna unguiculata) Powder Supplement on Post-Menopausal Vaginal Maturation Index at Malang, Indonesia Tatik Sujiati; Budi Siswanto; A Hidayat; Ayu Rizky Widowati
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (779.983 KB) | DOI: 10.55561/ajhr.v1i1.10

Abstract

Background: Only a few published studies have directly demonstrated the effects of local soy isoflavone on the post-menopausal vaginal maturation index. This study focused on the effect of 24 weeks of local soy isoflavone (67,5 mg) consumption to improve the post-menopausal vaginal maturation index. Material and Methods: 50 post-menopausal women were randomly assigned to a double-blind clinical trial to receive cowpea (Vigna unguiculata) powder treatment (n=25) and placebo (n=23). Vaginal cytology (maturation index, maturation value) was evaluated at pre and post-treatment in Anatomy Pathology Laboratories. Collected data were analyzed by using the analysis of covariant (ANOVA) method. Result: There is no difference in maturation vaginal index between the treatment and the placebo group. The treatment was not significantly improved the vaginal maturation index (p<0,05). The concomitant variable, age, post-menopausal interval, BMI, marital status, and initial cell condition have no significant effect on the maturation vagina index. Conclusion: Cowpea powder supplement with 67,5 mg isoflavone cannot improve the vaginal maturation index on post-menopausal patients.
Zinc Deficiency as Predictor of COVID-19 Severity: A Systematic Review and Meta-Analysis Ayu Rizky Widowati; Sutrisno Sutrisno
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (808.841 KB) | DOI: 10.55561/ajhr.v1i2.27

Abstract

Introduction: Despite the fact that zinc deficiency is asymptomatic, its incidence is rising over the world, with no visible clinical manifestation. Mineral and vitamin supplementation to prevent the inflammatory response is a major concern during the COVID-19 pandemic. Zinc may play a role in the development of a stronger immunological response. Nonetheless, there is insufficient information to investigate the benefits of zinc on its own. The impact of zinc deficiency on the severity of COVID-19 infection will be discussed in this systematic study. Material and Methods: We used the search phrases "COVID-19" or "SARS-CoV-2" and "Zinc Deficiency" to look for publications published between 2020 and April 2021 in scholar google, PubMed, SCOPUS, and Proquest. All of the information was examined qualitatively. Results: There are three papers that discuss the benefits of zinc and indicate that zinc deficiency has a key influence in the severity of COVID-19. According to one study, there is no link between zinc deficiency and COVID-19 severity. Conclusions: COVID-19 infection is linked to low zinc levels in the blood. It may become a risk factor for COVID-19 severity or a contributing factor that goes unnoticed in regular practice. Zinc supplementation or zinc baseline serum may play a role in determining potential daily supplementation and treatment for patients at risk of zinc insufficiency in the COVID-19 group in RCT and better design studies.
Co-Authors A Hidayat Budi Siswanto Sutrisno Sutrisno Tatik Sujiati