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All Journal Biology, Medicine, & Natural Product Chemistry
Chinomso Friday Aaron
Abia State University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Phytochemical Compositions and Antioxidant Properties of Combined Funtumia africana and Abutilon mauritianum Extract (CFAE) Robert Ikechukwu Uroko; Charles Nnanna Chukwu; Chinomso Friday Aaron; Umezurike Benedict Chidozie; Doris Akachukwu; Ndukwe Onyeani Atuh
Biology, Medicine, & Natural Product Chemistry Vol 11, No 2 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.112.111-118

Abstract

Medically active compounds in plants confer biological effects including antioxidant properties. This study evaluated the phytochemical content and in vitro antioxidant properties of combined Funtumia africana leaves and Abutilon mauritianum extract (CFAE). The 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), and nitric oxide radical (NO.) scavenging capabilities were used as antioxidant assay models. The results of the phytochemical analysis showed that CFAE is rich in alkaloids, flavonoids, tannins, saponins, phenols and cardiac glycosides. The extract contains antioxidant vitamins A, C and E, vitamin E being the most abundant. The CFAE showed a dose-dependent TAC based on the observed FRAP, TBARS, and DPPH scavenging activity which could be attributed to the presence of phenolic compounds and vitamins E. These strongly suggest that CFAE is a potential source of phytochemicals and antioxidants which could be exploited in the food and pharmaceutical industries in production of potent nutraceuticals or therapeutically-important products.
Combined Anthocleista vogelii and Alstonia boonei Stem Barks Extract Alleviates Hyperlipidaemia and Renal Malfunctions in Benign Prostatic Hyperplasia-Induced Rats Robert Ikechukwu Uroko; Mercylyn Ezinne Uche; Paul Chukwuemaka Nweje-Anyalowu; Ikenna Obiwuru; Chinedu Aguwamba; Chinomso Friday Aaron
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.69-78

Abstract

Benign prostatic hyperplasia (BPH) is a urological disease prevalent among the ageing male population, which impairs the quality of life, including hyperlipidaemia and a decline in renal functions. Combining Anthocleista vogelii and Alstonia boonei stem bark extract has effectively managed BPH and its associated complications. This study evaluated the effects of a combined Anthocleista vogelii and Alstonia boonei stem bark extract (CAASBE) on the lipid profile and renal functions of rats induced benign prostatic hyperplasia with testosterone propionate injection. The study comprised five treatment groups, with groups 1 5 being the normal control, BPH control, standard control, BPH+200 mg/kg CAASBE, and BPH+400 mg/kg CAASBE, respectively. BPH was induced in the groups 2 4 rats by subcutaneous administration of testosterone propionate injection (5 mg/kg) for 28 days, and treatment with Finasteride and CAASBE were administered orally. The BPH control rats exhibited a significant (p < 0.05) increase in the total serum cholesterol, triacylglycerol (TAG), low-density lipoprotein cholesterol (LDL-C), urea, creatinine and significant (p < 0.05) decline in the serum high-density lipoprotein cholesterol (HDL-C) compared to the normal control. Conversely, treatment of the BPH rats with 200 and 400 mg/kg of CAASBE significantly (p < 0.05) reversed the altered total serum cholesterol, TAG, LDL-C, HDL-C, urea and creatinine to normal levels comparable to that of the normal control and standard control respectively. These findings show that CAASBE alleviates hyperlipidaemia and renal malfunctions in the BPH rats suggesting it could be effective in managing BPH complication.
Co-Authors Charles Nnanna Chukwu Chinedu Aguwamba Doris Akachukwu Ikenna Obiwuru Mercylyn Ezinne Uche Ndukwe Onyeani Atuh Paul Chukwuemaka Nweje-Anyalowu Robert Ikechukwu Uroko Umezurike Benedict Chidozie